Ashoka H, Hegde P, Madihalli C et al (2017) Isolation and detection of vinca alkaloids from endophytes isolated from Catharanthus roseus. Eur J Biomed Pharm Sci 10:675–683

Google Scholar 

Ayob FW, Simarani K (2016) Endophytic filamentous fungi from a Catharanthus roseus: Identification and its hydrolytic enzymes. Saud Pharm J 24:273–278

Article  Google Scholar 

Birat K, Binsuwaidan R, Siddiqi TO, Mir SR, Alshammari N, Adnan M, Panda BP (2022) Report on vincristine-producing endophytic fungus Nigrosporazimmermanii from leaves of Catharanthus roseus. Metabolites 12(11):1119

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chandra S (2012) Endophytic fungi: novel sources of anticancer lead molecules. Appl Microbiol Biotechnol 95:47–59. https://doi.org/10.1007/s00253-012-4128-7

Article  CAS  PubMed  Google Scholar 

Doyle JJ, Doyle JL (1987) A rapid DNA isolation procedure for small quantities of fresh leaf tissue. Phytochem Bull 19(1):11–15

Google Scholar 

Duffin J (2002) Poisoning the spindle: serendipity and discovery of the anti-tumor properties of the Vinca alkaloids (Part II). Pharm Hist 44:105–118. https://doi.org/10.3138/cbmh.17.1.155

Article  PubMed  Google Scholar 

Fisher PJ, Petrini O et al (1992) Fungal saprobes and pathogens as endophytes of rice (Oryza sativa L.). New Phytol 120:137–143. https://doi.org/10.1111/j.1469-8137.1992.tb01066.x

Article  Google Scholar 

Guo B, Kunming LH (1998) A middle vinblastine fungus isolated. J Yunnan Univ 20:214–215

CAS  Google Scholar 

Gurnani NMDGMMBK, Mehta D, Gupta M, Mehta BK (2014) Natural products: source of potential drugs. Afr J Basic Appl Sci 6(6):171–186

Google Scholar 

Kumar A, Patil D, Rajamohanan PR et al (2013) Isolation, purification and characterization of vinblastine and vincristine from endophytic fungus Fusarium oxysporumisolated from Catharanthus roseus. PloS one 8:1–10. https://doi.org/10.1371/journal.pone.0071805

Article  CAS  Google Scholar 

Kwak JH, Kang MW, Roh JH et al (2009) Cytotoxic phenolic compounds from Chionanthusretusus. Arch Pharm Res 32:1681–1687. https://doi.org/10.1007/s12272-009-2203-0

Article  CAS  PubMed  Google Scholar 

Lay CS, Agustina I, Astuti P, Hertiani T (2023) Cytotoxic screening of endophytic fungi associated with Catharanthus roseus. Biodivers J Biol Divers. https://doi.org/10.13057/biodiv/d240525

Article  Google Scholar 

Li X, Xie H, Jiang Q et al (2017) The mechanism of (+) taxifolin’s protective antioxidant effect for OH-treated bone marrow-derived mesenchymal stem cells. Cell. Mol. Biol. Lett. 22:31–11. https://doi.org/10.1186/s11658-017-0066-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moudi M, Go R, Yien CY et al (2013) Vinca alkaloids. Int J Prev Med 4:1231–1235

PubMed  PubMed Central  Google Scholar 

Palem PPC, Kuriakose GC, Jayabaskaran C (2015) An endophytic fungus, Talaromycesradicus, isolated from Catharanthus roseus, produces vincristine and vinblastine, which induce apoptotic cell death. PLoS ONE. https://doi.org/10.1371/journal.pone.0144476

Article  PubMed  PubMed Central  Google Scholar 

Pandey SS, Singh S, Babu CV, Shanker K, Srivastava NK, Shukla AK, Kalra A (2016) Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis. Sci Rep 6(1):26583

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parthasarathy R, Shanmuganathan R, Pugazhendhi A (2020) Vinblastine production by the endophytic fungus Curvularia verruculosa from the leaves of Catharanthus roseus and it’s in vitro cytotoxicity against HeLa cell line. Anal Biochem. 593:113530. https://doi.org/10.1016/j.ab.2019.113530

Article  CAS  PubMed  Google Scholar 

Shriner RL, Hermann CKF, Morrill TC et al. The Systematic Identification of Organic Compounds.Wiley.1998.

Smulyan H (2018) The beat goes on: the story of five ageless cardiac drugs. Am J Med Sci 356:441–450

Article  PubMed  Google Scholar 

Sottomayor M, Lopes Cardoso I, Pereira L et al (2004) Peroxidase and the biosynthesis of terpenoid indole alkaloids in the medicinal plant Catharanthus roseus (L.) G Don. Phytochem Rev 3:159–71. https://doi.org/10.1023/B:PHYT.0000047807.66887.09

Article  CAS  Google Scholar 

Strobel GA (2002) Rainforest endophytes and bioactive products. Crit Rev Biotecnol 22:315–333

Article  CAS  Google Scholar 

Subbulakshmi GK, Thalavaipandian A, Bagyalakshmi RV et al (2012) Bioactive endophytic fungal isolates of Biota orientalis (L) Endl., Pinus excelsa Wall. and Thuja occidentalis L. Int. J. Adv Life Sci 4:9–15

Google Scholar 

Thorat MA, Cuzick J (2013) Role of Aspirin in cancer prevention. Curr Oncol Rep 15:533–540

Article  CAS  PubMed  Google Scholar 

Tung CY, Yang DB, Gou MA (2002) preliminary study on the condition of the culture and isolate of endophytic fungus producing Vincristine. J Chuxiong Normal Univ 6:39–41

Google Scholar 

Williams SD, Birch R, Einhorn LH et al (1987) Treatment of disseminated germ-cell tumours with cisplatin, bleomycin, and either - or etoposide. N Engl J Med 23:1435–1440

Article  Google Scholar 

Xi J, Tian LL, Xi J et al (2022) Alterperylenol as a novel thioredoxin reductase inhibitor induces liver cancer cell apoptosis and ferroptosis. J Agric Food Chem. 70:15763–15775. https://doi.org/10.1021/acs.jafc.2c05339

Zafari D, Leylaiee S, Tajick MA (2019) Isolation and identification of vinblastine from the fungus of Chaetomium globosum Cr95 isolated from Catharanthus roseus plant. B J M 8:1–14

Google Scholar 

Zhang L, Bo Gou, Haiyan L et al (2000) Preliminary study on the isolation of endophytic fungus of Catharanthus roseus and its fermentation to produce product of therapeutic value. Chinese Trad Herb Drugs 11:805–807

CAS  Google Scholar