Vincent AJ, Laven JS. Early menopause/premature ovarian insufficiency. Semin Reprod Med. 2020;38:235–6.

Article  PubMed  Google Scholar 

Li M, Zhu Y, Wei J, Chen L, Chen S, Lai D. The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis. Climacteric. 2023;26:95–102.

Article  CAS  PubMed  Google Scholar 

Pellicer N, Cozzolino M, Diaz-Garcia C, Galliano D, Cobo A, Pellicer A, et al. Ovarian rescue in women with premature ovarian insufficiency: facts and fiction. Reprod Biomed Online. 2023;46:543–65.

Article  PubMed  Google Scholar 

Yang Q, Mumusoglu S, Qin Y, Sun Y, Hsueh AJ. A kaleidoscopic view of ovarian genes associated with premature ovarian insufficiency and senescence. FASEB J. 2021;35: e21753.

Article  CAS  PubMed  Google Scholar 

Ai G, Meng M, Guo J, Li C, Zhu J, Liu L, et al. Adipose-derived stem cells promote the repair of chemotherapy-induced premature ovarian failure by inhibiting granulosa cells apoptosis and senescence. Stem Cell Res Ther. 2023;14:75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi YQ, Zhu XT, Zhang SN, Ma YF, Han YH, Jiang Y, et al. Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants. Front Endocrinol. 2023;14:1172481.

Article  Google Scholar 

Kovanci E, Schutt AK. Premature ovarian failure: clinical presentation and treatment. Obstet Gynecol Clin North Am. 2015;42:153–61.

Article  PubMed  Google Scholar 

Krylova SV, Feng D. The machinery of exosomes: biogenesis, release, and uptake. Int J Mol Sci. 2023;24:1337.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu X, Odenthal M, Fries JW. Exosomes as miRNA carriers: formation-function-future. Int J Mol Sci. 2016;17:2028.

Article  PubMed  PubMed Central  Google Scholar 

de Waard F, Trichopoulos D. A unifying concept of the aetiology of breast cancer. Int J Cancer. 1988;41:666–9.

Article  PubMed  Google Scholar 

Mao G, Xu Y, Long D, Sun H, Li H, Xin R, et al. Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis. Stem Cell Res Ther. 2021;12:389.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qu Q, Liu L, Cui Y, Liu H, Yi J, Bing W, et al. miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure. Stem Cell Res Ther. 2022;13:352.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xing J, Zhang M, Zhao S, Lu M, Lin L, Chen L, et al. EIF4A3-induced exosomal circLRRC8A alleviates granulosa cells senescence via the miR-125a-3p/NFE2L1 axis. Stem Cell Rev Rep. 2023;19:1994–2012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu M, Zhang D, Zhou X, Duan J, Hu Y, Zhang W, et al. Cell-free fat extract improves ovarian function and fertility in mice with premature ovarian insufficiency. Stem Cell Res Ther. 2022;13:320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Yuan Y, Zhang X, Lu Y, Dong N, Jiang X, et al. Human umbilical cord mesenchymal stem cell-derived exosomes attenuate oxygen-glucose deprivation/reperfusion-induced microglial pyroptosis by promoting FOXO3a-dependent mitophagy. Oxid Med Cell Longev. 2021;2021:6219715.

Article  PubMed  PubMed Central  Google Scholar 

Puzar Dominkus P, Stenovec M, Sitar S, Lasic E, Zorec R, Plemenitas A, et al. PKH26 labeling of extracellular vesicles: characterization and cellular internalization of contaminating PKH26 nanoparticles. Biochim Biophys Acta Biomembr. 2018;1860:1350–61.

Article  CAS  PubMed  Google Scholar 

Cao G, Meng X, Han X, Li J. Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-alpha-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a. Biosci Rep. 2020;40:BSR20193436.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li W, Li D, Kuang H, Feng X, Ai W, Wang Y, et al. Berberine increases glucose uptake and intracellular ROS levels by promoting Sirtuin 3 ubiquitination. Biomed Pharmacother. 2020;121:109563.

Article  CAS  PubMed  Google Scholar 

Ren Y, He J, Wang X, Liang H, Ma Y. Exosomes from adipose-derived stem cells alleviate premature ovarian failure via blockage of autophagy and AMPK/mTOR pathway. PeerJ. 2023;11: e16517.

Article  PubMed  PubMed Central  Google Scholar 

Isaac R, Reis FCG, Ying W, Olefsky JM. Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021;33:1744–62.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murphy DE, de Jong OG, Brouwer M, Wood MJ, Lavieu G, Schiffelers RM, et al. Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking. Exp Mol Med. 2019;51:1–12.

Article  CAS  PubMed  Google Scholar 

Guduric-Fuchs J, O’Connor A, Camp B, O’Neill CL, Medina RJ, Simpson DA. Selective extracellular vesicle-mediated export of an overlapping set of microRNAs from multiple cell types. BMC Genom. 2012;13:357.

Article  CAS  Google Scholar 

Shen W, Zhao X, Li S. Exosomes derived from ADSCs attenuate sepsis-induced lung injury by delivery of Circ-Fryl and regulation of the miR-490-3p/SIRT3 pathway. Inflammation. 2022;45:331–42.

Article  CAS  PubMed  Google Scholar 

Wu H, Ma H, Wang L, Zhang H, Lu L, Xiao T, et al. Regulation of lung epithelial cell senescence in smoking-induced COPD/emphysema by microR-125a-5p via Sp1 mediation of SIRT1/HIF-1a. Int J Biol Sci. 2022;18:661–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ataei-Nazari S, Amoushahi M, Madsen JF, Jensen J, Heuck A, Mohammadi-Sangcheshmeh A, et al. Cyclin-dependent kinase 6 (CDK6) as a potent regulator of the ovarian primordial-to-primary follicle transition. Front Cell Dev Biol. 2022;10:1036917.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goel S, Bergholz JS, Zhao JJ. Targeting CDK4 and CDK6 in cancer. Nat Rev Cancer. 2022;22:356–72.

Article  CAS  PubMed  PubMed Central  Google Scholar