Huang YC, Urban JP, Luk KD. Intervertebral disc regeneration: do nutrients lead the way? Nat Rev Rheumatol. 2014;10:561–6.
Kamali A, Ziadlou R, Lang G, Pfannkuche J, Cui S, Li Z, et al. Small molecule-based treatment approaches for intervertebral disc degeneration: current options and future directions. Theranostics. 2021;11:27–47.
Article CAS PubMed PubMed Central Google Scholar
Hajiesmailpoor A, Mohamadi O, Farzanegan G, Emami P, Ghorbani M. Overview of stem cell therapy in intervertebral disc disease: clinical perspective. Curr Stem Cell Res Ther. 2023;18:595–607.
Tsiapalis D, O’Driscoll L. Mesenchymal stem cell derived extracellular vesicles for tissue engineering and regenerative medicine applications. Cells. 2020;9:991.
Article CAS PubMed PubMed Central Google Scholar
Makarova J, Turchinovich A, Shkurnikov M, Tonevitsky A. Extracellular mirnas and cell-cell communication: problems and prospects. Trends Biochem Sci. 2021;46:640–51.
Article CAS PubMed Google Scholar
Wei A, Shen B, Williams L, Diwan A. Mesenchymal stem cells: potential application in intervertebral disc regeneration. Transl Pediatr. 2014;3:71–90.
PubMed PubMed Central Google Scholar
Piazza N, Dehghani M, Gaborski TR, Wuertz-Kozak K. Therapeutic potential of extracellular vesicles in degenerative diseases of the intervertebral disc. Front Bioeng Biotechnol. 2020;8:311.
Article PubMed PubMed Central Google Scholar
Howitt J, Hill AF. Exosomes in the pathology of neurodegenerative diseases. J Biol Chem. 2016;291:26589–97.
Article CAS PubMed PubMed Central Google Scholar
Shi Y, Wang Y, Li Q, Liu K, Hou J, Shao C, et al. Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases. Nat Rev Nephrol. 2018;14:493–507.
Article CAS PubMed Google Scholar
Liu Y, Wang Y, Lv Q, Li X. Exosomes: from garbage bins to translational medicine. Int J Pharm. 2020;583:119333.
Article CAS PubMed Google Scholar
Alcaraz MJ, Compan A, Guillen MI. Extracellular vesicles from mesenchymal stem cells as novel treatments for musculoskeletal diseases. Cells. 2019;9:98.
Article PubMed PubMed Central Google Scholar
Ahmadi M, Rezaie J. Ageing and mesenchymal stem cells derived exosomes: molecular insight and challenges. Cell Biochem Funct. 2021;39:60–6.
Article CAS PubMed Google Scholar
Huang R, Qin C, Wang J, Hu Y, Zheng G, Qiu G, et al. Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury. Aging (Albany NY). 2019;11:7996–8014.
Article CAS PubMed Google Scholar
Kirkland JL, Tchkonia T. Senolytic drugs: from discovery to translation. J Intern Med. 2020;288:518–36.
Article CAS PubMed PubMed Central Google Scholar
Cui Z, Zhao X, Amevor FK, Du X, Wang Y, Li D, et al. Therapeutic application of quercetin in aging-related diseases: sirt1 as a potential mechanism. Front Immunol. 2022;13:943321.
Article CAS PubMed PubMed Central Google Scholar
Navone SE, Marfia G, Giannoni A, Beretta M, Guarnaccia L, Gualtierotti R, et al. Inflammatory mediators and signalling pathways controlling intervertebral disc degeneration. Histol Histopathol. 2017;32:523–42.
Chao-Yang G, Peng C, Hai-Hong Z. Roles of nlrp3 inflammasome in intervertebral disc degeneration. Osteoarthritis Cartilage. 2021;29:793–801.
Article CAS PubMed Google Scholar
Zhao K, An R, Xiang Q, Li G, Wang K, Song Y, et al. Acid-sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the nlrp3 inflammasome in intervertebral disc degeneration. Cell Prolif. 2021;54:e12941.
Article CAS PubMed Google Scholar
DiStefano TJ, Vaso K, Danias G, Chionuma HN, Weiser JR, Iatridis JC. Extracellular vesicles as an emerging treatment option for intervertebral disc degeneration: therapeutic potential, translational pathways, and regulatory considerations. Adv Healthc Mater. 2022;11:e2100596.
Xia C, Zeng Z, Fang B, Tao M, Gu C, Zheng L, et al. Mesenchymal stem cell-derived exosomes ameliorate intervertebral disc degeneration via anti-oxidant and anti-inflammatory effects. Free Radic Biol Med. 2019;143:1–15.
Article CAS PubMed Google Scholar
Dai Z, Xia C, Zhao T, Wang H, Tian H, Xu O, et al. Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction. Mater Today Bio. 2023;18:100512.
Article CAS PubMed Google Scholar
Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine. 2001;26:1873–8.
Article CAS PubMed Google Scholar
Han B, Zhu K, Li FC, Xiao YX, Feng J, Shi ZL, et al. A simple disc degeneration model induced by percutaneous needle puncture in the rat tail. Spine. 2008;33:1925–34.
Chang YH, Wu KC, Harn HJ, Lin SZ, Ding DC. Exosomes and stem cells in degenerative disease diagnosis and therapy. Cell Transplant. 2018;27:349–63.
Article PubMed PubMed Central Google Scholar
Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022;7:272.
Article PubMed PubMed Central Google Scholar
Miyamoto T, Muneta T, Tabuchi T, Matsumoto K, Saito H, Tsuji K, et al. Intradiscal transplantation of synovial mesenchymal stem cells prevents intervertebral disc degeneration through suppression of matrix metalloproteinase-related genes in nucleus pulposus cells in rabbits. Arthritis Res Ther. 2010;12:R206.
Article PubMed PubMed Central Google Scholar
Vaudreuil N, Henrikson K, Pohl P, Lee A, Lin H, Olsen A, et al. Photopolymerizable biogel scaffold seeded with mesenchymal stem cells: safety and efficacy evaluation of novel treatment for intervertebral disc degeneration. J Orthop Res. 2019;37:1451–9.
Article CAS PubMed Google Scholar
Sakai D, Andersson GB. Stem cell therapy for intervertebral disc regeneration: obstacles and solutions. Nat Rev Rheumatol. 2015;11:243–56.
Liu H, Li R, Liu T, Yang L, Yin G, Xie Q. Immunomodulatory effects of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles in rheumatoid arthritis. Front Immunol. 1912;2020:11.
Weng Z, Zhang B, Wu C, Yu F, Han B, Li B, et al. Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer. J Hematol Oncol. 2021;14:136.
Article CAS PubMed PubMed Central Google Scholar
Liao Z, Li S, Lu S, Liu H, Li G, Ma L, et al. Metformin facilitates mesenchymal stem cell-derived extracellular nanovesicles release and optimizes therapeutic efficacy in intervertebral disc degeneration. Biomaterials. 2021;274:120850.
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