Cynarin inhibits microglia-induced pyroptosis and neuroinflammation via Nrf2/ROS/NLRP3 axis after spinal cord injury

Ahuja CS, Nori S, Tetreault L, Wilson J, Kwon B, Harrop J, et al. Traumatic spinal cord Injury-Repair and Regeneration. Neurosurgery. 2017;80:S9–22.

Article  PubMed  Google Scholar 

Anjum A, Yazid MD, Fauzi Daud M, Idris J, Ng AMH, Selvi Naicker A, et al. Spinal cord Injury: pathophysiology, Multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci. 2020;21:7533.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li C, Wu Z, Zhou L, Shao J, Hu X, Xu W, et al. Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury. Signal Transduct Target Ther. 2022;7:1–15.

PubMed  PubMed Central  Google Scholar 

Onyango IG, Jauregui GV, Čarná M, Bennett JP, Stokin GB. Neuroinflammation in Alzheimer’s Disease. Biomedicines. 2021;9:524.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Wang C, Chen D, Huang Y, Li J, Wei P, et al. The role of microglial/macrophagic salt-inducible kinase 3 on normal and excessive phagocytosis after transient focal cerebral ischemia. Cell Mol Life Sci CMLS. 2022;79:439.

Article  CAS  PubMed  Google Scholar 

Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Neuronal cell death. Physiol Rev. 2018;98:813–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18:2114–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rao Z, Zhu Y, Yang P, Chen Z, Xia Y, Qiao C, et al. Pyroptosis in inflammatory diseases and cancer. Theranostics. 2022;12:4310–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schroder K, Tschopp J. The inflammasomes. Cell. 2010;140:821–32.

Article  CAS  PubMed  Google Scholar 

Han X, Xu T, Fang Q, Zhang H, Yue L, Hu G, et al. Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy. Redox Biol. 2021;44:102010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al Mamun A, Wu Y, Monalisa I, Jia C, Zhou K, Munir F, et al. Role of pyroptosis in spinal cord injury and its therapeutic implications. J Adv Res. 2021;28:97–109.

Article  CAS  PubMed  Google Scholar 

Conti Filho CE, Loss LB, Marcolongo-Pereira C, Rossoni Junior JV, Barcelos RM, Chiarelli-Neto O, et al. Advances in Alzheimer’s disease’s pharmacological treatment. Front Pharmacol. 2023;14:1101452.

Article  PubMed  PubMed Central  Google Scholar 

Huang H, Young W, Skaper S, Chen L, Moviglia G, Saberi H, et al. Clinical neurorestorative therapeutic guidelines for spinal cord Injury (IANR/CANR version 2019). J Orthop Transl. 2020;20:14–24.

Google Scholar 

Evaniew N, Noonan VK, Fallah N, Kwon BK, Rivers CS, Ahn H, et al. Methylprednisolone for the treatment of patients with Acute spinal cord injuries: a propensity score-matched cohort study from a Canadian multi-center spinal cord Injury Registry. J Neurotrauma. 2015;32:1674–83.

Article  PubMed  PubMed Central  Google Scholar 

Liu Z, Yang Y, He L, Pang M, Luo C, Liu B, et al. High-dose methylprednisolone for acute traumatic spinal cord injury: a meta-analysis. Neurology. 2019;93:e841–50.

Article  CAS  PubMed  Google Scholar 

Limanaqi F, Biagioni F, Busceti CL, Polzella M, Fabrizi C, Fornai F. Potential antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxid Basel Switz. 2020;9:234.

Article  CAS  Google Scholar 

Hueza IM, Gotardo AT, da Silva Mattos MI, Górniak SL. Immunomodulatory effect of Cynara scolymus (artichoke) in rats. Phytother Res PTR. 2019;33:167–73.

Article  CAS  PubMed  Google Scholar 

Tong J, Mo Q-G, Ma B-X, Ge L-L, Zhou G, Wang Y-W. The protective effects of Cichorium Glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro. Food Funct. 2017;8:209–19.

Article  CAS  PubMed  Google Scholar 

Chen S, Tang S, Zhang C, Li Y. Cynarin ameliorates dextran sulfate sodium-induced acute colitis in mice through the STAT3/NF-κB pathway. Immunopharmacol Immunotoxicol. 2023;1–23.

Obmann A, Tsendayush D, Thalhammer T, Zehl M, Vo TPN, Purevsuren S, et al. Extracts from the Mongolian traditional medicinal plants Dianthus versicolorFisch. And Lilium Pumilum Delile stimulate bile flow in an isolated perfused rat liver model. J Ethnopharmacol. 2010;131:555–61.

Article  PubMed  Google Scholar 

Wu C, Chen S, Liu Y, Kong B, Yan W, Jiang T, et al. Cynarin suppresses gouty arthritis induced by monosodium urate crystals. Bioengineered. 2022;13:11782–93.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim DB, Unenkhuu B, Kim GJ, Kim S-W, Kim HS. Cynarin attenuates LPS-induced endothelial inflammation via upregulation of the negative regulator MKP-3. Anim Cells Syst. 2022;26:119–28.

Article  CAS  Google Scholar 

Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, Popovich PG. Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma. 2006;23:635–59.

Article  PubMed  Google Scholar 

Smolders SM-T, Kessels S, Vangansewinkel T, Rigo J-M, Legendre P, Brône B. Microglia: brain cells on the move. Prog Neurobiol. 2019;178:101612.

Article  CAS  PubMed  Google Scholar 

Colonna M, Butovsky O. Microglia function in the Central Nervous System during Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan H, Tang H-B, Chen Z, Wang H-Q, Zhang L, Jiang Y, et al. Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury. J Neuroinflammation. 2020;17:295.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee J-Y, Kim BJ, Sim G, Kim G-T, Kang D, Jung JH, et al. Spinal cord injury markedly altered protein expression patterns in the affected rat urinary bladder during healing stages. J Korean Med Sci. 2011;26:814–23.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang H-C, Lin Y-T, Hsu S-Y, Tsai N-W, Lai Y-R, Su BY-J, et al. Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury. J Transl Med. 2019;17:329.

Article  PubMed  PubMed Central  Google Scholar 

Kaur J, Singh H, Naqvi S. Intracellular DAMPs in Neurodegeneration and their role in clinical therapeutics. Mol Neurobiol. 2023;60:3600–16.

Article  CAS  PubMed  Google Scholar 

Gu L, Sun M, Li R, Zhang X, Tao Y, Yuan Y, et al. Didymin suppresses Microglia pyroptosis and Neuroinflammation through the Asc/Caspase-1/GSDMD pathway following experimental Intracerebral Hemorrhage. Front Immunol. 2022;13:810582.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai M, Zhuang W, Lv E, Liu Z, Wang Y, Zhang W, et al. Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson’s disease via inhibiting p38MAPK/NF-κB signaling pathway. Neurochem Int. 2022;152:105221.

Article  CAS 

Comments (0)

No login
gif