Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates

Arthur CM, Nalbant D, Feldman HA, Saeedi BJ, Matthews J, Robinson BS, et al. Anemia induces gut inflammation and injury in an animal model of preterm infants. Transfusion. 2019;59:1233–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cibulskis CC, Maheshwari A, Rao R, Mathur AM. Anemia of prematurity: how low is too low? J Perinatol. 2021;41:1244–57.

Article  PubMed  Google Scholar 

Higgins RD, Patel RM, Josephson CD. Preoperative Anemia and neonates. JAMA Pediatr. 2016;170:835–6.

Article  PubMed  PubMed Central  Google Scholar 

Maheshwari A, Patel RM, Christensen RD. Anemia, red blood cell transfusions, and necrotizing enterocolitis. Semin Pediatr Surg. 2018;27:47–51.

Article  PubMed  Google Scholar 

MohanKumar K, Namachivayam K, Sivakumar N, Alves NG, Sidhaye V, Das JK, et al. Severe neonatal anemia increases intestinal permeability by disrupting epithelial adherens junctions. Am J Physiol Gastrointest Liver Physiol. 2020;318:G705–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

MohanKumar K, Namachivayam K, Song T, Jake Cha B, Slate A, Hendrickson JE, et al. A murine neonatal model of necrotizing enterocolitis caused by anemia and red blood cell transfusions. Nat Commun. 2019;10:3494.

Article  PubMed  PubMed Central  Google Scholar 

Saroha V, Josephson CD, Patel RM. Epidemiology of necrotizing enterocolitis: New considerations regarding the influence of Red Blood Cell transfusions and Anemia. Clin Perinatol. 2019;46:101–17.

Article  PubMed  Google Scholar 

Whitehead HV, Vesoulis ZA, Maheshwari A, Rambhia A, Mathur AM. Progressive anemia of prematurity is associated with a critical increase in cerebral oxygen extraction. Early Hum Dev. 2020;140:104891.

Article  CAS  PubMed  Google Scholar 

Whitehead HV, Vesoulis ZA, Maheshwari A, Rao R, Mathur AM. Anemia of prematurity and cerebral near-infrared spectroscopy: should transfusion thresholds in preterm infants be revised? J Perinatol. 2018;38:1022–9.

Article  PubMed  PubMed Central  Google Scholar 

Rosebraugh MR, Widness JA, Nalbant D, Veng-Pedersen P. A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. Transfusion. 2013;53:1353–60.

Article  PubMed  Google Scholar 

Whyte RK, Jefferies AL, Canadian Paediatric Society F, Newborn C. Red blood cell transfusion in newborn infants. Paediatr Child Health. 2014;19:213–22.

Article  PubMed  PubMed Central  Google Scholar 

Baxi AC, Josephson CD, Iannucci GJ, Mahle WT. Necrotizing enterocolitis in infants with congenital heart disease: the role of red blood cell transfusions. Pediatr Cardiol. 2014;35:1024–9.

Article  PubMed  Google Scholar 

Elabiad MT, Harsono M, Talati AJ, Dhanireddy R. Effect of birth weight on the association between necrotising enterocolitis and red blood cell transfusions in < = 1500 g infants. BMJ Open. 2013;3:e003823.

Article  PubMed  PubMed Central  Google Scholar 

Josephson CD, Wesolowski A, Bao G, Sola-Visner MC, Dudell G, Castillejo MI, et al. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr. 2010;157:972–e9781.

Article  PubMed  PubMed Central  Google Scholar 

Chirico G, Beccagutti F, Sorlini A, Motta M, Perrone B. Red blood cell transfusion in preterm infants: restrictive versus liberal policy. J Matern Fetal Neonatal Med. 2011;24(Suppl 1):20–2.

Article  PubMed  Google Scholar 

Howarth C, Banerjee J, Aladangady N. Red blood cell transfusion in Preterm infants: current evidence and controversies. Neonatology. 2018;114:7–16.

Article  PubMed  Google Scholar 

Villeneuve A, Arsenault V, Lacroix J, Tucci M. Neonatal red blood cell transfusion. Vox Sang. 2021;116:366–78.

Article  PubMed  Google Scholar 

Abdelghaffar S, Mansi Y, Ibrahim R, Mohamed D. Red blood transfusion in preterm infants: changes in glucose, electrolytes and acid base balance. Asian J Transfus Sci. 2012;6:36–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aucott SW, Maheshwari A. To transfuse or not transfuse a premature infant: the new complex question. J Perinatol. 2019;39:351–3.

Article  PubMed  Google Scholar 

Aubron C, Nichol A, Cooper DJ, Bellomo R. Age of red blood cells and transfusion in critically ill patients. Ann Intensive Care. 2013;3:2.

Article  PubMed  PubMed Central  Google Scholar 

Escobar GA, Cheng AM, Moore EE, Johnson JL, Tannahill C, Baker HV, et al. Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes. Ann Surg. 2007;246:129–34.

Article  PubMed  PubMed Central  Google Scholar 

Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, et al. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion. 2010;50:1902–13.

Article  PubMed  Google Scholar 

Hod EA, Zhang N, Sokol SA, Wojczyk BS, Francis RO, Ansaldi D, et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood. 2010;115:4284–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Friedlander MH, Simon R, Machiedo GW. The relationship of packed cell transfusion to red blood cell deformability in systemic inflammatory response syndrome patients. Shock. 1998;9:84–8.

Article  CAS  PubMed  Google Scholar 

Kasivajjula H, Maheshwari A. Pathophysiology and current management of necrotizing enterocolitis. Indian J Pediatr. 2014;81:489–97.

Article  PubMed  Google Scholar 

Pammi M, De Plaen IG, Maheshwari A. Recent advances in necrotizing Enterocolitis Research: strategies for implementation in clinical practice. Clin Perinatol. 2020;47:383–97.

Article  PubMed  PubMed Central  Google Scholar 

Chung Y, Desiraju S, Namachivayam K, Guzman P, He L, MohanKumar K. Hematological changes in neonatal mice with phlebotomy-induced anemia. Pediatr Res. 2022;92:1575–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramatchandirin B, Balamurugan MA, Desiraju S, Chung Y, MohanKumar K. A detailed protocol for the induction of Anemia and RBC Transfusion-associated necrotizing enterocolitis in neonatal mice. Bio Protoc. 2024;14:e4993.

Article  PubMed  PubMed Central  Google Scholar 

Evans RW, Rafique R, Zarea A, Rapisarda C, Cammack R, Evans PJ, et al. Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera. J Biol Inorg Chem. 2008;13:57–74.

Article  CAS  PubMed  Google Scholar 

MohanKumar K, Kaza N, Jagadeeswaran R, Garzon SA, Bansal A, Kurundkar AR, et al. Gut mucosal injury in neonates is marked by macrophage infiltration in contrast to pleomorphic infiltrates in adult: evidence from an animal model. Am J Physiol Gastrointest Liver Physiol. 2012;303:G93–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

MohanKumar K, Namachivayam K, Chapalamadugu KC, Garzon SA, Premkumar MH, Tipparaju SM, et al. Smad7 interrupts TGF-beta signaling in intestinal macrophages and promotes inflammatory activation of these cells during necrotizing enterocolitis. Pediatr Res. 2016;79:951–61.

Article  CAS 

Comments (0)

No login
gif