Alpha-galactosylceramide pre-treatment attenuates clinical symptoms of LPS-induced acute neuroinflammation by converting pathogenic iNKT cells to anti-inflammatory iNKT10 cells in the brain

Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, et al. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia. 2007;55:453–62.

Article  PubMed  PubMed Central  Google Scholar 

Zhao J, Bi W, Xiao S, Lan X, Cheng X, Zhang J, et al. Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice. Sci Rep. 2019;9:5790.

Article  PubMed  PubMed Central  Google Scholar 

Thomson CA, McColl A, Graham GJ, Cavanagh J. Sustained exposure to systemic endotoxin triggers chemokine induction in the brain followed by a rapid influx of leukocytes. J Neuroinflammation. 2020;17:94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He H, Geng T, Chen P, Wang M, Hu J, Kang L, et al. NK cells promote neutrophil recruitment in the brain during sepsis-induced neuroinflammation. Sci Rep. 2016;6:27711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SW, Park HJ, Van Kaer L, Hong S. Roles and therapeutic potential of CD1d-Restricted NKT cells in inflammatory skin diseases. Front Immunol. 2022;13: 979370.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Kaer L, Wu L. Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity. Front Immunol. 2018;9:519.

Article  PubMed  PubMed Central  Google Scholar 

Lee YJ, Holzapfel KL, Zhu J, Jameson SC, Hogquist KA. Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells. Nat Immunol. 2013;14:1146–54.

Article  CAS  PubMed  Google Scholar 

Uchida T, Nakashima H, Yamagata A, Ito S, Ishikiriyama T, Nakashima M, et al. Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice. Sci Rep. 2018;8:8225.

Article  PubMed  PubMed Central  Google Scholar 

Horikoshi M, Goto D, Segawa S, Yoshiga Y, Iwanami K, Inoue A, et al. Activation of Invariant NKT cells with glycolipid ligand alpha-galactosylceramide ameliorates glucose-6-phosphate isomerase peptide-induced arthritis. PLoS ONE. 2012;7: e51215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coppieters K, Van Beneden K, Jacques P, Dewint P, Vervloet A, Vander Cruyssen B, et al. A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner. J Immunol. 2007;179:2300–9.

Article  CAS  PubMed  Google Scholar 

Sag D, Krause P, Hedrick CC, Kronenberg M, Wingender G. IL-10-producing NKT10 cells are a distinct regulatory invariant NKT cell subset. J Clin Invest. 2014;124:3725–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park HJ, Kim TC, Park YH, Lee SW, Jeon J, Park SH, et al. Repeated alpha-GalCer administration induces a type 2 cytokine-biased iNKT Cell response and exacerbates atopic skin inflammation in valpha14(Tg) NC/Nga Mice. Biomedicines. 2021;9:1619.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wingender G, Sag D, Kronenberg M. NKT10 cells: a novel iNKT cell subset. Oncotarget. 2015;6:26552–3.

Article  PubMed  PubMed Central  Google Scholar 

Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, et al. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015;16:85–95.

Article  CAS  PubMed  Google Scholar 

Chen D, Zhao H, Gao X, Chen S, Liu H, Zhang J, et al. Subcutaneous administration of alpha-GalCer activates iNKT10 cells to promote M2 macrophage polarization and ameliorates chronic inflammation of obese adipose tissue. Int Immunopharmacol. 2019;77: 105948.

Article  CAS  PubMed  Google Scholar 

Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nat Immunol. 2022;23:878–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, et al. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature. 2019;565:246–50.

Article  CAS  PubMed  Google Scholar 

Spath S, Roan F, Presnell SR, Hollbacher B, Ziegler SF. Profiling of Tregs across tissues reveals plasticity in ST2 expression and hierarchies in tissue-specific phenotypes. iScience. 2022;25:104998.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie D, Miao W, Xu F, Yuan C, Li S, Wang C, et al. IL-33/ST2 axis protects against traumatic brain injury through enhancing the function of regulatory T cells. Front Immunol. 2022;13: 860772.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hua J, Liang S, Ma X, Webb TJ, Potter JP, Li Z. The interaction between regulatory T cells and NKT cells in the liver: a CD1d bridge links innate and adaptive immunity. PLoS ONE. 2011;6: e27038.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SW, Park HJ, Cheon JH, Wu L, Van Kaer L, Hong S. iNKT cells suppress pathogenic NK1.1(+)CD8(+) T cells in DSS-induced colitis. Front Immunol. 2018;9:2168.

Article  PubMed  PubMed Central  Google Scholar 

Halpert G, Eitan T, Voronov E, Apte RN, Rath-Wolfson L, Albeck M, et al. Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis. J Biol Chem. 2014;289:17215–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalechman Y, Gafter U, Gal R, Rushkin G, Yan D, Albeck M, et al. Anti-IL-10 therapeutic strategy using the immunomodulator AS101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention. J Immunol. 2002;169:384–92.

Article  CAS  PubMed  Google Scholar 

Li X, Han Z, Wang F, Qiao J. The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway. Allergy Asthma Clin Immunol. 2022;18:12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee YJ, Kim K, Kim M, Ahn YH, Kang JL. Inhibition of STAT6 activation by AS1517499 inhibits expression and activity of PPARgamma in macrophages to resolve acute inflammation in mice. Biomolecules. 2022;12:447.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SW, Oh SY, Park HJ, Kim TC, Park YH, Van Kaer L, et al. Phosphorothioate-linked guanine/cytosine-based stem-loop oligonucleotides induce the extracellular release of mitochondrial DNA from peritoneal B1a cells. Int J Biol Macromol. 2022;223:252–62.

Article  CAS  PubMed  Google Scholar 

Park HJ, Lee SW, Van Kaer L, Lee MS, Hong S. IL-7 deficiency exacerbates atopic dermatitis in NC/Nga mice. Int J Mol Sci. 2023;24:9956.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SW, Park HJ, Van Kaer L, Hong S. Opposing roles of DCs and iNKT cells in the induction of Foxp3 expression by MLN CD25(+)CD4(+) T cells during IFNgamma-driven colitis. Int J Mol Sci. 2022;23:15316.

Article  CAS 

Comments (0)

No login
gif