Beghi E, Giussani G, Nichols E et al (2019) Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet Neurol 18:357–375
Téllez-Zenteno JF, Hernández-Ronquillo L (2012) A review of the epidemiology of temporal lobe epilepsy. Epilepsy Res Treat 2012
Myint PK, Staufenberg EFA, Sabanathan K (2006) Post-stroke seizure and post-stroke epilepsy. Postgrad Med J 82:568–572
Article CAS PubMed PubMed Central Google Scholar
French JA (2007) Refractory epilepsy: clinical overview. Epilepsia 48:3–7
Temkin NR (2001) Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia 42:515–524
Article CAS PubMed Google Scholar
Alqurashi RS, Yee AS, Malone T et al (2021) A Warburg-like metabolic program coordinates wnt, AMPK, and mTOR signaling pathways in epileptogenesis. PLoS ONE 16:e0252282
Article CAS PubMed PubMed Central Google Scholar
Gupta K, Schnell E (2019) Neuronal network remodeling and wnt pathway dysregulation in the intra-hippocampal kainate mouse model of temporal lobe epilepsy. PLoS ONE 14:e0215789
Article CAS PubMed PubMed Central Google Scholar
Sun C, Fu J, Qu Z et al (2021) Chronic intermittent hypobaric hypoxia restores hippocampus function and rescues cognitive impairments in chronic epileptic rats via Wnt/β-catenin signaling. Front Mol Neurosci 13:617143
Article PubMed PubMed Central Google Scholar
Jean W-H, Huang C-T, Hsu J-H et al (2022) Anticonvulsive and neuroprotective effects of eupafolin in rats are associated with the inhibition of glutamate overexcitation and upregulation of the Wnt/β-Catenin signaling pathway. ACS Chem Neurosci 13:1594–1603
Article CAS PubMed Google Scholar
Gautam V, Rawat K, Sandhu A et al (2021) An insight into crosstalk among multiple signaling pathways contributing to epileptogenesis. Eur J Pharmacol 910:174469. https://doi.org/10.1016/j.ejphar.2021.174469
Article CAS PubMed Google Scholar
Oliva CA, Vargas JY, Inestrosa NC (2013) Wnts in adult brain: from synaptic plasticity to cognitive deficiencies. Front Cell Neurosci 7:224
Article CAS PubMed PubMed Central Google Scholar
Mardones MD, Andaur GA, Varas-Godoy M et al (2016) Frizzled-1 receptor regulates adult hippocampal neurogenesis. Mol Brain 9:1–12
Arredondo SB, Guerrero FG, Herrera-Soto A et al (2020) Wnt5a promotes differentiation and development of adult-born neurons in the hippocampus by noncanonical wnt signaling. Stem Cells 38:422–436
Article CAS PubMed Google Scholar
Choe Y, Pleasure SJ (2013) Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression. Dev Neurosci 34:502–514
Madsen TM, Newton SS, Eaton ME et al (2003) Chronic electroconvulsive seizure up-regulates β-catenin expression in rat hippocampus: role in adult neurogenesis. Biol Psychiatry 54:1006–1014
Article CAS PubMed Google Scholar
Qu Z, Su F, Qi X et al (2017) Wnt/β-catenin signalling pathway mediated aberrant hippocampal neurogenesis in kainic acid‐induced epilepsy. Cell Biochem Funct 35:472–476
Article CAS PubMed Google Scholar
Rubio C, Rosiles-Abonce A, Trejo-Solis C et al (2017) Increase signaling of Wnt/β-catenin pathway and presence of apoptosis in cerebellum of kindled rats. CNS neurol disord targets (formerly Curr Drug targets-. CNS Neurol Disord 16:772–780
Theilhaber J, Rakhade SN, Sudhalter J et al (2013) Gene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and wnt signaling in epileptogenesis. PLoS ONE 8:e74428
Article CAS PubMed PubMed Central Google Scholar
Yang J, Zhang X, Wu Y et al (2016) Wnt/β-catenin signaling mediates the seizure‐facilitating effect of postischemic reactive astrocytes after pentylenetetrazole‐kindling. Glia 64:1083–1091
Komiya Y, Habas R (2008) Wnt signal transduction pathways. Organogenesis 4:68–75. https://doi.org/10.4161/org.4.2.5851
Article PubMed PubMed Central Google Scholar
Rawat K, Gautam V, Sandhu A et al (2023) Differential regulation of Wnt/β-catenin signaling in acute and chronic epilepsy in repeated low dose lithium-pilocarpine rat model of status epilepticus. Neuroscience. https://doi.org/10.1016/j.neuroscience.2023.10.019
Vougogiannopoulou K, Skaltsounis A-L (2012) From Tyrian purple to kinase modulators: naturally halogenated indirubins and synthetic analogues. Planta Med 78:1515–1528
Article CAS PubMed Google Scholar
Zhang X, Castanotto D, Nam S et al (2017) 6BIO enhances oligonucleotide activity in cells: a potential combinatorial anti-androgen receptor therapy in prostate cancer cells. Mol Ther 25:79–91
Article CAS PubMed PubMed Central Google Scholar
Shen S, Xu N, Klamer G et al (2015) Small-molecule inhibitor of glycogen synthase kinase 3β 6-bromoindirubin-3-oxime inhibits hematopoietic regeneration in stem cell recipient mice. Stem Cells Dev 24:724–736
Article CAS PubMed Google Scholar
Avrahami L, Farfara D, Shaham-Kol M et al (2013) Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem 288:1295–1306
Article CAS PubMed Google Scholar
Suresh SN, Chavalmane AK, Dj V et al (2017) A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. Autophagy 13:1221–1234. https://doi.org/10.1080/15548627.2017.1302045
Article CAS PubMed PubMed Central Google Scholar
Mook RA Jr, Wang J, Ren X-R et al (2015) Structure–activity studies of Wnt/β-catenin inhibition in the Niclosamide chemotype: identification of derivatives with improved drug exposure. Bioorg Med Chem 23:5829–5838
Article CAS PubMed PubMed Central Google Scholar
Moskaleva EY, Perevozchikova VG, Zhirnik AS, Severin SE (2015) Molecular mechanisms of niclosamide antitumor activity. Biomeditsinskaya Khim 61:680–693
Osada T, Chen M, Yang XY et al (2011) Antihelminth compound niclosamide downregulates wnt signaling and elicits antitumor responses in tumors with activating APC mutations. Cancer Res 71:4172–4182
Article CAS PubMed PubMed Central Google Scholar
Mahajan N, Mishra S, Warokar A et al (2024) Pharmacokinetics of Niclosamide in Rat plasma by RP HPLC via Intranasal and Intraperitoneal Route of Administration. J Appl Bioanal 10:62–72
Kang M-J, Kim MJ, Kim A et al (2024) Pharmacokinetic interactions of niclosamide in rats: involvement of organic anion transporters 1 and 3 and organic cation transporter 2. Chem Biol Interact 390:110886
Article CAS PubMed Google Scholar
Milani M, Della Valle I, Rossi S et al (2024) Neuroprotective effects of niclosamide on disease progression via inflammatory pathways modulation in SOD1-G93A and FUS-associated amyotrophic lateral sclerosis models. Neurotherapeutics 21:e00346
Comments (0)