Human Papillomaviruses 16 and 18 E6 Oncoprotein Detection Test in Primary Oropharyngeal Carcinomas and Metastatic Lymph Nodes: A Cross-Sectional Study

Lechner M, Liu J, Masterson L, Fenton TR (2022) HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management. Nat Rev Clin Oncol 19:306–327

Article  PubMed  PubMed Central  Google Scholar 

Boscolo-Rizzo P, Polesel J, Del Mistro A, Fratta E, Lazzarin C, Menegaldo A et al (2023) Rising trend in the prevalence of HPV-driven oropharyngeal squamous cell carcinoma during 2000–2022 in Northeastern Italy: implication for Using p16INK4a as a Surrogate Marker for HPV-Driven Carcinogenesis. Cancers 15:2643

Article  PubMed  PubMed Central  Google Scholar 

Mehanna H, Alemany L, von Buchwald C (2024) Advances in testing for human papillomavirus-mediated head and neck cancer. Curr Opin Oncol 36:143–146

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boscolo-Rizzo P, Pawlita M, Holzinger D (2016) From HPV-positive towards HPV-driven oropharyngeal squamous cell carcinomas. Cancer Treat Rev 42:24–29

Article  PubMed  Google Scholar 

Bussu F, Ragin C, Boscolo-Rizzo P, Rizzo D, Gallus R, Delogu G et al (2019) HPV as a marker for molecular characterization in head and neck oncology: looking for a standardization of clinical use and of detection method(s) in clinical practice. Head Neck 41:1104–1111

Article  PubMed  Google Scholar 

Simoens C, Gheit T, Ridder R, Gorbaslieva I, Holzinger D, Lucas E et al (2022) Accuracy of high-risk HPV DNA PCR, p16(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer. BMC Infect Dis 22:676

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boscolo-Rizzo P, Dietz A (2017) The AJCC/UICC eighth edition for staging head and neck cancers: Is it wise to de-escalate treatment regimens in p16-positive oropharyngeal cancer patients? Int J Cancer 141:1490–1491

Nauta IH, Rietbergen MM, Van Bokhoven AA, Bloemena E, Lissenberg-Witte BI, Heideman DA, de Jong RB, Brakenhoff RH, Leemans CR (2018) Evaluation of the eighth TNM classification on p16-positive oropharyngeal squamous cell carcinomas in the Netherlands and the importance of additional HPV DNA testing. Ann Oncol Off J Eur Soc Med Oncol. 29:1273–1279

Article  CAS  Google Scholar 

Mehanna H, Taberna M, von Buchwald C, Tous S, Brooks J, Mena M et al (2023) Prognostic implications of p16 and HPV discordance in oropharyngeal cancer (HNCIG-EPIC-OPC): a multicentre, multinational, individual patient data analysis. Lancet Oncol 24:239–251

Article  PubMed  CAS  Google Scholar 

Bussu F, Muresu N, Crescio C, Gallus R, Rizzo D, Cossu A et al (2022) Low prevalence of HPV related oropharyngeal carcinogenesis in Northern Sardinia. Cancers 14:4205

Article  PubMed  PubMed Central  CAS  Google Scholar 

Mena M, Taberna M, Tous S, Marquez S, Clavero O, Quiros B et al (2018) Double positivity for HPV-DNA/p16ink4a is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients. Oral Oncol 78:137–144

Article  PubMed  CAS  Google Scholar 

Chioreanu A, Balica NC, Mot CI, Bugari R, Morar R, Baderca F et al (2024) A retrospective analysis from western romania comparing the treatment and survivability of p16-positive versus p16-negative oropharyngeal cancer. Cancers 16:945

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karp EE, Yin LX, Moore EJ, Elias AJ, O’Byrne TJ, Glasgow AE et al (2021) Barriers to obtaining a timely diagnosis in human papillomavirus-associated oropharynx cancer. Otolaryngol-Head Neck Surg Off J Am Acad Otolaryngol-Head Neck Surg 165:300–308

Article  Google Scholar 

Caudell JJ, Gillison ML, Maghami E, Spencer S, Pfister DG, Adkins D et al (2022) NCCN Guidelines® insights: head and neck cancers, version 1.2022. J Natl Compr Cancer Netw JNCCN 20:224–234

Article  PubMed  Google Scholar 

Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX (2002) Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene 21:1510–1517

Article  PubMed  CAS  Google Scholar 

Lindquist D, Romanitan M, Hammarstedt L, Näsman A, Dahlstrand H, Lindholm J et al (2007) Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7. Mol Oncol 1:350–355

Article  PubMed  PubMed Central  Google Scholar 

Menegaldo A, Schroeder L, Holzinger D, Tirelli G, Dal Cin E, Tofanelli M et al (2021) Detection of HPV16/18 E6 oncoproteins in head and neck squamous cell carcinoma using a protein immunochromatographic assay. Laryngoscope 131:1042–1048

Article  PubMed  CAS  Google Scholar 

Nobre RJ, de Almeida LP, Martins TC (2008) Complete genotyping of mucosal human papillomavirus using a restriction fragment length polymorphism analysis and an original typing algorithm. J Clin Virol Off Publ Pan Am Soc Clin Virol 42:13–21

Article  CAS  Google Scholar 

Mariano VS, Lorenzi AT, Scapulatempo-Neto C, Stein MD, Resende JCP, Antoniazzi M et al (2016) A low-cost HPV Immunochromatographic assay to detect high-grade cervical intraepithelial neoplasia. PLoS ONE 11:e0164892

Article  PubMed  PubMed Central  Google Scholar 

Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig L et al (2015) STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies. BMJ 351:h5527

Article  PubMed  PubMed Central  Google Scholar 

Murphy CT, Galloway TJ, Handorf EA, Wang L, Mehra R, Flieder DB et al (2015) Increasing time to treatment initiation for head and neck cancer: an analysis of the National Cancer Database. Cancer 121:1204–1213

Article  PubMed  Google Scholar 

Polesel J, Furlan C, Birri S, Giacomarra V, Vaccher E, Grando G et al (2017) The impact of time to treatment initiation on survival from head and neck cancer in north-eastern Italy. Oral Oncol 67:175–182

Article  PubMed  Google Scholar 

Liao DZ, Schlecht NF, Rosenblatt G, Kinkhabwala CM, Leonard JA, Ference RS et al (2019) Association of delayed time to treatment initiation with overall survival and recurrence among patients with head and neck squamous cell carcinoma in an underserved urban population. JAMA Otolaryngol—Head Neck Surg 145:1001–1009

Article  PubMed  PubMed Central  Google Scholar 

Boscolo-Rizzo P, Schroeder L, Romeo S, Pawlita M (2015) The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: a systematic review. Clin Exp Metastasis 32:835–845

Article  PubMed  CAS  Google Scholar 

Schroeder L, Boscolo-Rizzo P, Dal Cin E, Romeo S, Baboci L, Dyckhoff G et al (2017) Human papillomavirus as prognostic marker with rising prevalence in neck squamous cell carcinoma of unknown primary: a retrospective multicentre study. Eur J Cancer 74:73–81

Article  PubMed  Google Scholar 

Zengel P, Assmann G, Mollenhauer M, Jung A, Sotlar K, Kirchner T et al (2012) Cancer of unknown primary originating from oropharyngeal carcinomas are strongly correlated to HPV positivity. Virchows Arch Int J Pathol 461:283–290

Article  Google Scholar 

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