Prognostic Utility of Autophagy Marker Beclin1 in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Ichimiya T, Yamakawa T, Hirano T et al (2020) Autophagy and autophagy-related diseases: a review. Int J Mol Sci 21:8974. https://doi.org/10.3390/ijms21238974

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanida I (2011) Autophagy basics. Microbiol Immunol 55:1–11. https://doi.org/10.1111/j.1348-0421.2010.00271.x

Article  CAS  PubMed  Google Scholar 

Choi AMK, Ryter SW, Levine B (2013) Autophagy in human health and disease. N Engl J Med 368:651–662. https://doi.org/10.1056/NEJMra1205406

Article  CAS  PubMed  Google Scholar 

Bhutia SK, Mukhopadhyay S, Sinha N et al (2013) Autophagy: cancer’s friend or foe? Adv Cancer Res 118:61–95. https://doi.org/10.1016/B978-0-12-407173-5.00003-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yun CW, Lee SH (2018) The roles of autophagy in cancer. Int J Mol Sci 19:3466. https://doi.org/10.3390/ijms19113466

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang W-C, Chang C-F, Li Y-H et al (2019) A histopathological evaluation and potential prognostic implications of oral squamous cell carcinoma with adverse features. Oral Oncol 95:65–73. https://doi.org/10.1016/j.oraloncology.2019.06.012

Article  PubMed  Google Scholar 

Zhao T, Liang S, Ju W et al (2020) High-risk lymph node ratio predicts worse prognosis in patients with locally advanced oral cancer. J Oral Pathol Med 49:787–795. https://doi.org/10.1111/jop.13043

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang J-Y, Hsi E, Huang Y-C et al (2015) Overexpression of autophagy-related 16-like 1 in patients with oral squamous cell carcinoma. Pathol Oncol Res POR 21:301–305. https://doi.org/10.1007/s12253-014-9821-7

Article  CAS  PubMed  Google Scholar 

Tang J-Y, Fang Y-Y, Hsi E et al (2013) Immunopositivity of Beclin-1 and ATG5 as indicators of survival and disease recurrence in oral squamous cell carcinoma. Anticancer Res 33:5611–5616

PubMed  Google Scholar 

Sakakura K, Takahashi H, Kaira K et al (2015) Immunological significance of the accumulation of autophagy components in oral squamous cell carcinoma. Cancer Sci 106:1–8. https://doi.org/10.1111/cas.12559

Article  CAS  PubMed  Google Scholar 

Nomura H, Uzawa K, Yamano Y et al (2009) Overexpression and altered subcellular localization of autophagy-related 16-like 1 in human oral squamous-cell carcinoma: correlation with lymphovascular invasion and lymph-node metastasis. Hum Pathol 40:83–91. https://doi.org/10.1016/j.humpath.2008.06.018

Article  CAS  PubMed  Google Scholar 

Liu J-L, Chen F-F, Lung J et al (2014) Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma. Br J Cancer 111:944–954. https://doi.org/10.1038/bjc.2014.355

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang J-Y, Hsi E, Huang Y-C et al (2013) High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma. Hum Pathol 44:2558–2562. https://doi.org/10.1016/j.humpath.2013.06.017

Article  CAS  PubMed  Google Scholar 

Barca I, Mignogna C, Novembre D et al (2021) Immunohistochemical analysis of the Beclin-1 expression predicts the progression of oral squamous cell carcinoma. Int J Environ Res Public Health 18:11125. https://doi.org/10.3390/ijerph182111125

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J-L, Chen F-F, Chang S-F et al (2015) Expression of Beclin family proteins is associated with tumor progression in oral cancer. PLoS ONE 10:e0141308. https://doi.org/10.1371/journal.pone.0141308

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu Z, Zhong Z, Huang S et al (2016) Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma. Mol Med Rep 14:1567–1573. https://doi.org/10.3892/mmr.2016.5437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Wang C, Tang H et al (2013) Decrease of autophagy activity promotes malignant progression of tongue squamous cell carcinoma. J Oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol 42:557–564. https://doi.org/10.1111/jop.12049

Article  CAS  Google Scholar 

Nishida Y, Arakawa S, Fujitani K et al (2009) Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461:654–658. https://doi.org/10.1038/nature08455

Article  PubMed  Google Scholar 

Yang Z, Klionsky DJ (2009) An overview of the molecular mechanism of autophagy. In: Levine B, Yoshimori T, Deretic V (eds) Autophagy in infection and immunity. Springer, Berlin, pp 1–32

Google Scholar 

McKnight NC, Yue Z (2013) Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Curr Pathobiol Rep 1:231–238. https://doi.org/10.1007/s40139-013-0028-5

Article  PubMed  PubMed Central  Google Scholar 

Qu X, Yu J, Bhagat G et al (2003) Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Investig 112:1809–1820. https://doi.org/10.1172/JCI20039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yue Z, Jin S, Yang C et al (2003) Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci 100:15077–15082. https://doi.org/10.1073/pnas.2436255100

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kongara S, Kravchuk O, Teplova I et al (2010) Autophagy regulates keratin 8 homeostasis in mammary epithelial cells and in breast tumors. Mol Cancer Res MCR 8:873–884. https://doi.org/10.1158/1541-7786.MCR-09-0494

Article  CAS  PubMed  Google Scholar 

Zhao Y, Chen S, Gou W et al (2014) Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma. Tumour Biol J Int Soc Oncodevelopmental Biol Med 35:1955–1964. https://doi.org/10.1007/s13277-013-1261-6

Article  CAS  Google Scholar 

Cai M, Hu Z, Liu J et al (2014) Beclin 1 expression in ovarian tissues and its effects on ovarian cancer prognosis. Int J Mol Sci 15:5292–5303. https://doi.org/10.3390/ijms15045292

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Du Z, Li L et al (2015) Beclin 1 and p62 expression in non-small cell lung cancer: relation with malignant behaviors and clinical outcome. Int J Clin Exp Pathol 8:10644–10652

CAS  PubMed  PubMed Central  Google Scholar 

Geng Q-R, Xu D-Z, He L-J et al (2012) Beclin-1 expression is a significant predictor of survival in patients with lymph node-positive gastric cancer. PLoS ONE 7:e45968. https://doi.org/10.1371/journal.pone.0045968

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao Q-H, Liu F, Yang Z-L et al (2016) Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. Am J Transl Res 8:3831–3847

CAS  PubMed  PubMed Central  Google Scholar 

Hu F, Li G, Huang C et al (2020) The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation. Cell Death Dis 11:304. https://doi.org/10.1038/s41419-020-2467-3

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