Halperin JJ, Eikeland R, Branda JA, Dersch R (2022) Lyme neuroborreliosis: known knowns, known unknowns. Brain 145:2635–2647. https://doi.org/10.1093/brain/awac206

Article  PubMed  Google Scholar 

Lantos PM, Rumbaugh J, Bockenstedt LK et al (2021) Clinical practice guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 guidelines for the prevention, diagnosis, and treatment of lyme disease. Neurology 96:262–273. https://doi.org/10.1212/WNL.0000000000011151

Article  PubMed  Google Scholar 

Mygland A, Ljostad U, Fingerle V et al (2010) EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 17(8–16):e11-14. https://doi.org/10.1111/j.1468-1331.2009.02862.x

Article  Google Scholar 

Agosta F, Rocca MA, Benedetti B, Capra R, Cordioli C, Filippi M (2006) MR imaging assessment of brain and cervical cord damage in patients with neuroborreliosis. AJNR Am J Neuroradiol 27:892–894

PubMed  PubMed Central  CAS  Google Scholar 

Fernandez RE, Rothberg M, Ferencz G, Wujack D (1990) Lyme disease of the CNS: MR imaging findings in 14 cases. AJNR Am J Neuroradiol 11:479–481

PubMed  PubMed Central  CAS  Google Scholar 

Halperin JJ, Luft BJ, Anand AK et al (1989) Lyme neuroborreliosis: central nervous system manifestations. Neurology 39:753–759

Article  PubMed  CAS  Google Scholar 

Halperin JJ, Pass HL, Anand AK, Luft BJ, Volkman DJ, Dattwyler RJ (1988) Nervous system abnormalities in Lyme disease. Ann N Y Acad Sci 539:24–34

Article  PubMed  CAS  Google Scholar 

Kruger H, Heim E, Schuknecht B, Scholz S (1991) Acute and chronic neuroborreliosis with and without CNS involvement: a clinical, MRI, and HLA study of 27 cases. J Neurol 238:271–280

Article  PubMed  CAS  Google Scholar 

Logigian EL, Johnson KA, Kijewski MF et al (1997) Reversible cerebral hypoperfusion in Lyme encephalopathy. Neurology 49:1661–1670

Article  PubMed  CAS  Google Scholar 

Morgen K, Martin R, Stone RD et al (2001) FLAIR and magnetization transfer imaging of patients with post-treatment Lyme disease syndrome. Neurology 57:1980–1985

Article  PubMed  CAS  Google Scholar 

Agarwal R, Sze G (2009) Neuro-lyme disease: MR imaging findings. Radiology 253:167–173. https://doi.org/10.1148/radiol.2531081103

Article  PubMed  Google Scholar 

Andreassen S, Lindland EMS, Solheim AM et al (2021) Cognitive function, fatigue and Fazekas score in patients with acute neuroborreliosis. Ticks Tick Borne Dis 12:101678. https://doi.org/10.1016/j.ttbdis.2021.101678

Article  PubMed  Google Scholar 

Orbaek M, Bodilsen J, Gynthersen RMM et al (2020) CT and MR neuroimaging findings in patients with Lyme neuroborreliosis: a national prospective cohort study. J Neurol Sci 419:117176. https://doi.org/10.1016/j.jns.2020.117176

Article  PubMed  Google Scholar 

Aalto A, Sjowall J, Davidsson L, Forsberg P, Smedby O (2007) Brain magnetic resonance imaging does not contribute to the diagnosis of chronic neuroborreliosis. Acta Radiol 48:755–762. https://doi.org/10.1080/02841850701367903

Article  PubMed  CAS  Google Scholar 

Marvel CL, Alm KH, Bhattacharya D et al (2022) A multimodal neuroimaging study of brain abnormalities and clinical correlates in post treatment Lyme disease. PLoS ONE 17:e0271425. https://doi.org/10.1371/journal.pone.0271425

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ljostad U, Skarpaas T, Mygland A (2007) Clinical usefulness of intrathecal antibody testing in acute Lyme neuroborreliosis. Eur J Neurol 14:873–876. https://doi.org/10.1111/j.1468-1331.2007.01799.x

Article  PubMed  CAS  Google Scholar 

Andreassen S, Lindland EMS, Beyer MK et al (2022) Assessment of cognitive function, structural brain changes and fatigue 6 months after treatment of neuroborreliosis. J Neurol. https://doi.org/10.1007/s00415-022-11463-7

Andreassen S, Solheim AM, Ljostad U et al (2022) Cognitive function in patients with neuroborreliosis: a prospective cohort study from the acute phase to 12 months post treatment. Brain Behav 12:e2608. https://doi.org/10.1002/brb3.2608

Lindland ES, Solheim AM, Andreassen S et al (2023) Dynamic contrast-enhanced MRI shows altered blood-brain barrier function of deep gray matter structures in neuroborreliosis: a case-control study. Eur Radiol Exp 7:52. https://doi.org/10.1186/s41747-023-00365-6

Lindland ES, Solheim AM, Dareez MN et al (2022) Enhancement of cranial nerves in Lyme neuroborreliosis: incidence and correlation with clinical symptoms and prognosis. Neuroradiology 64:2323–2333. https://doi.org/10.1007/s00234-022-02957-2

Solheim AM, Ljostad U, Mygland A (2019) Six versus two weeks treatment with doxycycline in Lyme neuroborreliosis: the protocol of a multicentre, non-inferiority, double-blinded and randomised controlled trial. BMJ Open 9:e027083. https://doi.org/10.1136/bmjopen-2018-027083

Solheim AM, Lorentzen AR, Dahlberg AO et al (2022) Six versus 2 weeks treatment with doxycycline in European Lyme neuroborreliosis: a multicentre, non-inferiority, double-blinded, randomised and placebo-controlled trial. J Neurol Neurosurg Psychiatry 93:1222–1228. https://doi.org/10.1136/jnnp-2022-329724

Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA (1987) MR signal abnormalities at 1.5 T in Alzheimer’s dementia and normal aging. AJR Am J Roentgenol 149:351–356. https://doi.org/10.2214/ajr.149.2.351

Article  PubMed  CAS  Google Scholar 

Rovang MS, Selnes P, MacIntosh BJ et al (2023) Segmenting white matter hyperintensities on isotropic three-dimensional fluid attenuated inversion recovery magnetic resonance images: assessing deep learning tools on a Norwegian imaging database. PLoS ONE 18:e0285683. https://doi.org/10.1371/journal.pone.0285683

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yushkevich PA, Piven J, Hazlett HC et al (2006) User-guided 3D active contour segmentation of anatomical structures: significantly improved efficiency and reliability. Neuroimage 31:1116–1128. https://doi.org/10.1016/j.neuroimage.2006.01.015

Article  PubMed  Google Scholar 

Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46:1121–1123. https://doi.org/10.1001/archneur.1989.00520460115022

Article  PubMed  CAS  Google Scholar 

Koo TK, Li MY (2016) A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 15:155–163. https://doi.org/10.1016/j.jcm.2016.02.012

Article  PubMed  PubMed Central  Google Scholar 

Dice LR (1945) Measures of the amount of ecologic association between species. Egcology 26:297–302

Article  Google Scholar 

Jochems ACC, Arteaga C, Chappell F et al (2022) Longitudinal changes of white matter hyperintensities in sporadic small vessel disease: a systematic review and meta-analysis. Neurology 99:e2454–e2463. https://doi.org/10.1212/WNL.0000000000201205

Article  PubMed  PubMed Central  CAS  Google Scholar 

Khalil M, Pirpamer L, Hofer E et al (2020) Serum neurofilament light levels in normal aging and their association with morphologic brain changes. Nat Commun 11:812. https://doi.org/10.1038/s41467-020-14612-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Landis J, Koch G (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174

Article  PubMed  CAS  Google Scholar 

Brown R, Low A, Markus HS (2021) Rate of, and risk factors for, white matter hyperintensity growth: a systematic review and meta-analysis with implications for clinical trial design. J Neurol Neurosurg Psychiatry 92:1271–1277. https://doi.org/10.1136/jnnp-2021-326569

Article  PubMed  Google Scholar 

van Leijsen EMC, van Uden IWM, Ghafoorian M et al (2017) Nonlinear temporal dynamics of cerebral small vessel disease: the RUN DMC study. Neurology 89:1569–1577. https://doi.org/10.1212/WNL.0000000000004490

Article  PubMed  PubMed Central  Google Scholar 

Beuchat I, Dunet V, Meylan P, Du Pasquier R (2018) Late Lyme neuroborreliosis with chronic encephalomyelitis. Neurology 91:627–628. https://doi.org/10.1212/WNL.0000000000006252

Article  PubMed  Google Scholar 

Erhart DK, Bracknies V, Lutz-Schuhbauer S, Wigand S, Tumani H (2022) The special role of CXCL13 in Lyme neuroborreliosis: a case report. Neurol Res Pract 4:3.