Infectious complications following transperineal prostate biopsy with or without periprocedural antibiotic prophylaxis—a systematic review including meta-analysis of all comparative studies

Uleri A, Baboudjian M, Tedde A, Gallioli A, Long-Depaquit T, Palou J, et al. Is there an impact of transperineal versus transrectal magnetic resonance imaging-targeted biopsy in clinically significant prostate cancer detection rate? A systematic review and meta-analysis. Eur Urol Oncol. 2023;6:621–8.

Article  PubMed  Google Scholar 

Wu Q, Tu X, Zhang C, Ye J, Lin T, Liu Z, et al. Transperineal magnetic resonance imaging targeted biopsy versus transrectal route in the detection of prostate cancer: a systematic review and meta-analysis. Prostate Cancer Prostatic Dis. 2024;27:212–21.

Hogenhout R, Remmers S, van Leenders G, Roobol MJ. The transition from transrectal to transperineal prostate biopsy without antibiotic prophylaxis: Ccancer detection rates and complication rates. Prostate Cancer Prostatic Dis. 2023;26:581–7.

Article  PubMed  Google Scholar 

Kanagarajah A, Hogan D, Yao HH, Dundee P, O’Connell HE. A systematic review on the outcomes of local anaesthetic transperineal prostate biopsy. BJU Int. 2023;131:408–23.

Article  PubMed  Google Scholar 

Wei JT, Barocas D, Carlsson S, Coakley F, Eggener S, Etzioni R, et al. Early detection of prostate cancer: AUA/SUO guideline part I: prostate cancer screening. J Urol. 2023;210:46–53.

Article  PubMed  PubMed Central  Google Scholar 

Bonkat G, Bartoletti R, Bruyère F, Cai T, Geerlings SE, Köves B, et al. EAU guidelines on urological infections. EAU Guidelines Office, Arnhem: the Netherlands; 2024.

Cornford P, Tilki D, Bergh RCNVD, Briers E, Eberli D, Meerleer GD, et al. EAU - EANM - ESTRO - ESUR - ISUP - SIOG guidelines on prostate cancer. EAU Guidelines Office, Arnhem: the Netherlands; 2024.

Forsvall A, Jonsson H, Wagenius M, Bratt O, Linder A. Rate and characteristics of infection after transrectal prostate biopsy: a retrospective observational study. Scand J Urol. 2021;55:317–23.

Article  PubMed  Google Scholar 

Basourakos SP, Alshak MN, Lewicki PJ, Cheng E, Tzeng M, DeRosa AP, et al. Role of prophylactic antibiotics in transperineal prostate biopsy: a systematic review and meta-analysis. Eur Urol Open Sci. 2022;37:53–63.

Article  PubMed  PubMed Central  Google Scholar 

Castellani D, Pirola GM, Law YXT, Gubbiotti M, Giulioni C, Scarcella S, et al. Infection rate after transperineal prostate biopsy with and without prophylactic antibiotics: results from a systematic review and meta-analysis of comparative studies. J Urol. 2022;207:25–34.

Article  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. J Clin Epidemiol. 2021;134:178–89.

Article  PubMed  Google Scholar 

Knoll T, Omar MI, Maclennan S, Hernandez V, Canfield S, Yuan Y, et al. Key steps in conducting systematic reviews for underpinning clinical practice guidelines: methodology of the European Association of Urology. Eur Urol. 2018;73:290–300.

Article  PubMed  Google Scholar 

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019;366:l4898.

Article  PubMed  Google Scholar 

Stone JC, Glass K, Ritskes-Hoitinga M, Munn Z, Tugwell P, Doi SAR. Methodological quality assessment should move beyond design specificity. JBI Evid Synth. 2023;21:507–19.

PubMed  Google Scholar 

Montgomery P, Movsisyan A, Grant SP, Macdonald G, Rehfuess EA. Considerations of complexity in rating certainty of evidence in systematic reviews: a primer on using the GRADE approach in global health. BMJ Glob Health. 2019;4:e000848.

Article  PubMed  PubMed Central  Google Scholar 

Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011;64:383–94.

Article  PubMed  Google Scholar 

Antimicrobial Resistance C. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399:629–55.

Article  Google Scholar 

James ND, Tannock I, N’Dow J, Feng F, Gillessen S, Ali SA, et al. The Lancet Commission on prostate cancer: planning for the surge in cases. Lancet. 2024;403:1683–722.

Article  PubMed  Google Scholar 

Pilatz A, Stangl F, Kranz J, Bonkat G, Veeratterapillay R. Transperineal is the way to go. Eur Urol Focus. 2024;10:691–3.

Hu JC, Assel M, Allaf ME, Ehdaie B, Vickers AJ, Cohen AJ, et al. Transperineal versus transrectal magnetic resonance imaging-targeted and systematic prostate biopsy to prevent infectious complications: the prevent randomized trial. Eur Urol. 2024;86:61–8.

Miano R, Manenti G, Orecchia L. TRexit is going one step further. Prostate Cancer Prostatic Dis. 2024;27:361–2.

Article  PubMed  Google Scholar 

Hu JC, Assel M, Allaf ME, Vickers AJ, Ehdaie B, Cohen AJ, et al. Transperineal vs transrectal prostate biopsy—The PREVENT randomized clinical trial. JAMA Oncol. 2024;10:1590–3.

Mian BM, Feustel PJ, Aziz A, Kaufman RP Jr, Bernstein A, Avulova S, et al. Complications following transrectal and transperineal prostate biopsy: results of the ProBE-PC randomized clinical trial. J Urol. 2024;211:205–13.

Article  PubMed  Google Scholar 

Newman TH, Stroman L, Hadjipavlou M, Haque A, Rusere J, Chan K, et al. EXIT from TRansrectal prostate biopsies (TREXIT): sepsis rates of transrectal biopsy with rectal swab culture guided antimicrobials versus freehand transperineal biopsy. Prostate Cancer Prostatic Dis. 2022;25:283–7.

Article  CAS  PubMed  Google Scholar 

Ploussard G, Barret E, Fiard G, Lenfant L, Malavaud B, Giannarini G, et al. Transperineal versus transrectal magnetic resonance imaging-targeted biopsies for prostate cancer diagnosis: final results of the randomized PERFECT trial (CCAFU-PR1). Eur Urol Oncol. 2024;7:1080–7.

Diamand R, Guenzel K, Mjaess G, Lefebvre Y, Ferriero M, Simone G, et al. Transperineal or transrectal magnetic resonance imaging-targeted biopsy for prostate cancer detection. Eur Urol Focus. 2024;10:805–11.

Pernigoni N, Guo C, Gallagher L, Yuan W, Colucci M, Troiani M, et al. The potential role of the microbiota in prostate cancer pathogenesis and treatment. Nat Rev Urol. 2023;20:706–18.

Article  PubMed  Google Scholar 

Zhong W, Wu K, Long Z, Zhou X, Zhong C, Wang S, et al. Gut dysbiosis promotes prostate cancer progression and docetaxel resistance via activating NF-kappaB-IL6-STAT3 axis. Microbiome. 2022;10:94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pfail J, Drobner J, Doppalapudi K, Saraiya B, Packiam V, Ghodoussipour S. The role of tumor and host microbiome on immunotherapy response in urologic cancers. J Cancer Immunol. 2024;6:1–13.

Article  Google Scholar 

Ditonno F, Franco A, Manfredi C, Veccia A, Valerio M, Bukavina L, et al. Novel non-MRI imaging techniques for primary diagnosis of prostate cancer: micro-ultrasound, contrast-enhanced ultrasound, elastography, multiparametric ultrasound, and PSMA PET/CT. Prostate Cancer Prostatic Dis. 2024;27:29–36.

Article  CAS  PubMed  Google Scholar 

Meissner VH, Rauscher I, Schwamborn K, Neumann J, Miller G, Weber W, et al. Radical prostatectomy without prior biopsy following multiparametric magnetic resonance imaging and prostate-specific membrane antigen positron emission tomography. Eur Urol. 2022;82:156–60.

Article  PubMed  Google Scholar 

Niu S, Ding X, Liu B, Ao L, Wang H, Chen W, et al. Radical prostatectomy without prior biopsy in selected patients evaluated by (18)F-labeled prostate-specific membrane antigen-ligand positron emission tomography/computed tomography and multiparameter magnetic resonance imaging: a single-center, prospective, single-arm trial. J Urol. 2024;212:280–9.

Article  PubMed  Google Scholar 

Chernysheva DY, Popov SV, Orlov IN, Tsoy AV, Neraldovskiy VA. The first experience of transperineal prostate biopsy without antibiotic prophylaxis. Onkourologiya. 2021;17:46–52.

Article  Google Scholar 

Jacewicz M, Gunzel K, Rud E, Sandbaek G, Magheli A, Busch J, et al. Antibiotic prophylaxis versus no antibiotic prophylaxis in transperineal prostate biopsies (NORAPP): a randomised, open-label, non-inferiority trial. Lancet Infect Dis. 2022;22:1465–71.

Article  CAS  PubMed  Google Scholar 

Packer MG, Russo P, Fair WR. Prophylactic antibiotics and Foley catheter use in transperineal needle biopsy of the prostate. J Urol. 1984;131:687–9.

Article  CAS  PubMed  Google Scholar 

Lee F, Gray JM, McLeary RD, Lee F Jr, McHugh TA, Solomon MH, et al. Prostatic evaluation by transrectal sonography: criteria for diagnosis of early carcinoma. Radiology. 1986;158:91–5.

Article  CAS  PubMed  Google Scholar 

Ristau BT, Allaway M, Cendo D, Hart J, Riley J, Parousis V, et al. Free-hand transperineal prostate biopsy provides acceptable cancer detection and minimizes risk of infection: evolving experience with a 10-sector template. Urol Oncol. 2018;36:528.e15–e20.

Article  PubMed  Google Scholar 

Wetterauer C, Shahin O, Federer-Gsponer JR, Keller N, Wyler S, Seifert HH, et al. Feasibility of freehand MRI/US cognitive fusion transperineal biopsy of the prostate in local anaesthesia as in-office procedure-experience with 400 patients. Prostate Cancer Prostatic Dis. 2020;23:429–34.

Article  CAS  PubMed  Google Scholar 

John JB, Maccormick A, Macdonagh R, Vennam R, Speakman MJ, Burns-Cox N. Antibiotic prophylaxis is not necessary before local anaesthetic transperineal prostate biopsies - an institution’s experience of 443 consecutive cases. Eur Urol. 2021;79:S1406–S7.

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