Pyridoxal 5′-phosphate and risk of stroke: triangulation of evidence from a nationally representative cohort and bidirectional Mendelian randomization analysis

Feigin VL, Brainin M, Norrving B, Martins S, Sacco RL, Hacke W, Fisher M, Pandian J, Lindsay P. World Stroke Organization (WSO): global stroke fact sheet 2022. Int J Stroke. 2022;17(1):18–29.

Article  PubMed  Google Scholar 

Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, et al. Heart disease and stroke statistics-2023 update: a report from the American Heart Association. Circulation. 2023;147(8):e93–621.

Article  PubMed  Google Scholar 

Martin SS, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Barone Gibbs B, Beaton AZ, Boehme AK, et al. 2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. 2024;149(8):e347–913.

Article  PubMed  Google Scholar 

Wu S, Wu B, Liu M, Chen Z, Wang W, Anderson CS, Sandercock P, Wang Y, Huang Y, Cui L, et al. Stroke in China: advances and challenges in epidemiology, prevention, and management. Lancet Neurol. 2019;18(4):394–405.

Article  PubMed  Google Scholar 

Wilson MP, Plecko B, Mills PB, Clayton PT. Disorders affecting vitamin B(6) metabolism. J Inherit Metab Dis. 2019;42(4):629–46.

Article  CAS  PubMed  Google Scholar 

Minović I, Kieneker LM, Gansevoort RT, Eggersdorfer M, Touw DJ, Voerman AJ, Connelly MA, Boer RA, Hak E, Bos J, et al. Vitamin B6, inflammation, and cardiovascular outcome in a population-based cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) study. Nutrients. 2020;12(9):2711.

Article  PubMed  PubMed Central  Google Scholar 

Mocellin S, Briarava M, Pilati P. Vitamin B6 and cancer risk: a field synopsis and meta-analysis. J Natl Cancer Inst. 2017;109(3):1–9.

Article  PubMed  Google Scholar 

Del Bo C, Riso P, Gardana C, Brusamolino A, Battezzati A, Ciappellano S. Effect of two different sublingual dosages of vitamin B(12) on cobalamin nutritional status in vegans and vegetarians with a marginal deficiency: a randomized controlled trial. Clin Nutr. 2019;38(2):575–83.

Article  PubMed  Google Scholar 

Kato N, Kimoto A, Zhang P, Bumrungkit C, Karunaratne S, Yanaka N, Kumrungsee T. Relationship of low vitamin B6 status with sarcopenia, frailty, and mortality: a narrative review. Nutrients. 2024;16(1):177.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hankey GJ. B vitamins for stroke prevention. Stroke Vasc Neurol. 2018;3(2):51–8.

Article  PubMed  PubMed Central  Google Scholar 

Zhang P, Xie X, Zhang Y. Associations between homocysteine and B vitamins and stroke: a cross-sectional study. Front Neurol. 2023;14:1184141.

Article  PubMed  PubMed Central  Google Scholar 

Wang C, Li B, Zhu Q, Zhang Q, Xie Z, Xie H, Li X. Dietary vitamin B6 intake and stroke are negatively associated in adults: a cross-sectional study from the NHANES. Heliyon. 2024;10(10):e31125.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang B, Dong H, Xu Y, Xu D, Sun H, Han L. Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort. Eur J Clin Nutr. 2023;77(3):299–307.

Article  CAS  PubMed  Google Scholar 

Ueland PM, McCann A, Midttun Ø, Ulvik A. Inflammation, vitamin B6 and related pathways. Mol Aspects Med. 2017;53:10–27.

Article  CAS  PubMed  Google Scholar 

Bajic Z, Sobot T, Skrbic R, Stojiljkovic MP, Ponorac N, Matavulj A, Djuric DM. Homocysteine, vitamins B6 and folic acid in experimental models of myocardial infarction and heart failure-how strong is that link? Biomolecules. 2022;12(4):536.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjørklund G, Peana M, Dadar M, Lozynska I, Chirumbolo S, Lysiuk R, Lenchyk L, Upyr T, Severin B. The role of B vitamins in stroke prevention. Crit Rev Food Sci Nutr. 2022;62(20):5462–75.

Article  PubMed  Google Scholar 

Al Mughram MH, Ghatge MS, Kellogg GE, Safo MK. Elucidating the interaction between pyridoxine 5’-phosphate oxidase and dopa decarboxylase: activation of B6-dependent enzyme. Int J Mol Sci. 2022;24(1):642.

Article  PubMed  PubMed Central  Google Scholar 

Bisello G, Ribeiro RP, Perduca M, Belviso BD, Polverino De’Laureto P, Giorgetti A, Caliandro R, Bertoldi M. Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: implication in aromatic amino acid decarboxylase deficiency. Protein Sci. 2023;32(8):e4732.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shah AK, Dhalla NS. Effectiveness of some vitamins in the prevention of cardiovascular disease: a narrative review. Front Physiol. 2021;12:729255.

Article  PubMed  PubMed Central  Google Scholar 

Paez-Hurtado AM, Calderon-Ospina CA, Nava-Mesa MO. Mechanisms of action of vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) in pain: a narrative review. Nutr Neurosci. 2023;26(3):235–53.

Article  CAS  PubMed  Google Scholar 

Zhang N, Wu Z, Bai X, Song Y, Li P, Lu X, Huo Y, Zhou Z. Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review. Am J Clin Nutr. 2024;119(3):821–8.

Article  CAS  PubMed  Google Scholar 

Mascolo E, Vernì F. Vitamin B6 and diabetes: relationship and molecular mechanisms. Int J Mol Sci. 2020;21(10):3669.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stach K, Stach W, Augoff K. Vitamin B6 in health and disease. Nutrients. 2021;13(9):3229.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang X, Glubb DM, O’Mara TA. Dietary factors and endometrial cancer risk: a Mendelian randomization study. Nutrients. 2023;15(3):603.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan S, Mason AM, Carter P, Burgess S, Larsson SC. Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study. BMC Med. 2021;19(1):97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Song F. A causal relationship between antioxidants, minerals and vitamins and metabolic syndrome traits: a Mendelian randomization study. Diabetol Metab Syndr. 2023;15(1):194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sekula P, Del Greco MF, Pattaro C, Köttgen A. Mendelian randomization as an approach to assess causality using observational data. J Am Soc Nephrol. 2016;27(11):3253–65.

Article  PubMed  PubMed Central  Google Scholar 

Kintu C, Soremekun O, Kamiza AB, Kalungi A, Mayanja R, Kalyesubula R, Bagaya SB, Jjingo D, Fabian J, Gill D, et al. The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study. EBioMedicine. 2023;90:104537.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Israr MZ, Bernieh D, Salzano A, Cassambai S, Yazaki Y, Heaney LM, Jones DJL, Ng LL, Suzuki T. Association of gut-related metabolites with outcome in acute heart failure. Am Heart J. 2021;234:71–80.

Article  CAS  PubMed  Google Scholar 

Bubnov RV, Spivak MY, Lazarenko LM, Bomba A, Boyko NV. Probiotics and immunity: provisional role for personalized diets and disease prevention. EPMA J. 2015;6(1):14.

Article  PubMed 

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