Hachamovitch R, Berman DS, Shaw LJ, Kiat H, Cohen I, Cabico JA, Friedman J, Diamond GA (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97:535–543

Article  CAS  PubMed  Google Scholar 

Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS (2003) Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 107:2900–2907

Article  PubMed  Google Scholar 

Shaw LJ, Berman DS, Maron DJ, Mancini GB, Hayes SW, Hartigan PM, Weintraub WS, O’Rourke RA, Dada M, Spertus JA, Chaitman BR, Friedman J, Slomka P, Heller GV, Germano G, Gosselin G, Berger P, Kostuk WJ, Schwartz RG, Knudtson M, Veledar E, Bates ER, McCallister B, Teo KK, Boden WE, Investigators COURAGE (2008) Optimal medical therapy with or without percutaneous coronary intervention to reduce ischemic burden: results from the clinical outcomes utilizing revascularization and aggressive drug evaluation (COURAGE) trial nuclear substudy. Circulation 117:1283–1291

Article  PubMed  Google Scholar 

Germano G, Kiat H, Kavanagh PB, Moriel M, Mazzanti M, Su HT, Van Train KF, Berman DS (1995) Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 36:2138–2147

CAS  PubMed  Google Scholar 

Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, Friedman JD, Zellweger MJ, Berman DS (1999) Incremental prognostic value of post-stress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 100:1035–1042

Article  CAS  PubMed  Google Scholar 

Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL, Iskandrian AE (2005) Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 12:687–695

Article  PubMed  Google Scholar 

Garcia EV, Faber TL, Cooke CD, Folks RD, Chen J, Santana C (2007) The increasing role of quantification in clinical nuclear cardiology: The Emory approach. J Nucl Cardiol 14:420–432

Article  PubMed  Google Scholar 

Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, van der Wall EE, Schalij MJ, Garcia EV, Bax JJ (2007) Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med 48:1104–1111

Article  PubMed  Google Scholar 

Goldberg AS, Alraies MC, Cerqueira MD, Jaber WA, Aljaroudi WA (2014) Prognostic value of left ventricular mechanical dyssynchrony by phase analysis in patients with non-ischemic cardiomyopathy with ejection fraction 35–50% and QRS < 150 ms. J Nucl Cardiol 21:57–66

Article  PubMed  Google Scholar 

Hess PL, Shaw LK, Fudim M, Iskandrian AE, Borges-Neto S (2017) The prognostic value of mechanical left ventricular dyssynchrony defined by phase analysis from gated single-photon emission computed tomography myocardial perfusion imaging among patients with coronary heart disease. J Nucl Cardiol 24:482–490

Article  PubMed  Google Scholar 

Hida S, Chikamori T, Tanaka H, Igarashi Y, Shiba C, Usui Y, Hatano T, Yamashina A (2012) Diagnostic value of left ventricular dyssynchrony after exercise and at rest in the detection of multivessel coronary artery disease on single-photon emission computed tomography. Circ J 76:1942–1952

Article  PubMed  Google Scholar 

Garcia-Cardenas M, Espejel-Guzman A, Antonio-Villa NE, Michel-Vasquez A, Hernandez-Sandoval S, Serrano-Roman J, Fernandez-Badillo V, Solorzano-Pinot E, Zagal-Cardoso D, Keirns C, Alexanderson-Rosas E, Espinola-Zavaleta N (2023) Diagnosis, performance and added value of assessing ventricular dyssynchrony by phase analysis in patients with three-vessel disease: a single-center cross-sectional study in Mexico. J Nucl Cardiol 30:1219–1229

Article  PubMed  Google Scholar 

Kuronuma K, Miller RJH, Otaki Y, Van Kriekinge SD, Diniz MA, Sharir T, Hu LH, Gransar H, Liang JX, Parekh T, Kavanagh PB, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Tamarappoo BK, Dey D, Berman DS, Slomka PJ (2021) Prognostic value of phase analysis for predicting adverse cardiac events beyond conventional single-photon emission computed tomography variables: results from the REFINE SPECT Registry. Circ Cardiovasc Imaging 14:e012386

Article  PubMed  PubMed Central  Google Scholar 

Kano N, Okumura T, Isobe S, Sawamura A, Watanabe N, Fukaya K, Mori H, Morimoto R, Kato K, Bando YK, Murohara T (2018) Left ventricular phase entropy: Novel prognostic predictor in patients with dilated cardiomyopathy and narrow QRS. J Nucl Cardiol 25:1677–1687

Article  PubMed  Google Scholar 

Shimizu M, Iiya M, Fujii H, Kimura S, Suzuki M, Nishizaki M (2021) Left ventricular end-systolic contractile entropy can predict cardiac prognosis in patients with complete left bundle branch block. J Nucl Cardiol 28:162–171

Article  PubMed  Google Scholar 

Berman DS, Kiat H, Friedman JD, Wang FP, van Train K, Matzer L, Maddahi J, Germano G (1993) Separate acquisition rest thalium-201/stress technetium-99m sestamibi dual-isotope myocardial perfusion single-photon emission computed tomography: A clinical validation study. J Am Coll Cardiol 22:1455–1464

Article  CAS  PubMed  Google Scholar 

Hatta T, Yoda S, Hayase M, Monno K, Hori Y, Fujito H, Suzuki Y, Matsumoto N, Okumura Y (2020) Prognostic value of left ventricular dyssynchrony assessed with nuclear cardiology in patients with known or suspected stable coronary artery disease with preserved left ventricular ejection fraction. Int Heart J 61:685–694

Article  CAS  PubMed  Google Scholar 

Fujito H, Yoda S, Hatta T, Miyagawa M, Tanaka Y, Fukumoto K, Suzuki Y, Matsumoto N, Okumura Y (2022) Prognostic value of the normalization of left ventricular mechanical dyssynchrony after revascularization in patients with coronary artery disease. Heart Vessels 37:1395–1410

Article  PubMed  Google Scholar 

Miyagawa M, Yoda S, Fujito H, Hatta T, Tanaka Y, Fukumoto K, Suzuki Y, Matsumoto N, Okumura Y (2023) Prognostic risk stratification based on left ventricular mechanical dyssynchrony in patients at low or intermediate risk of major cardiac events using the J-ACCESS risk model. Heart Vessels 38:195–206

Article  PubMed  Google Scholar 

Berman DS, Abidov A, Kang X, Hayes SW, Friedman JD, Sciammarella MG, Cohen I, Gerlach J, Waechter PB, Germano G, Hachamovitch R (2004) Prognostic validation of a 17-segment score derived from a 20-segment score for myocardial perfusion SPECT interpretation. J Nucl Cardiol 11:414–423

Article  PubMed  Google Scholar 

Nakae I, Hayashi H, Matsumoto T, Mitsunami K, Horie M (2014) Clinical usefulness of a novel program “Heart Function View” for evaluating cardiac function from gated myocardial perfusion SPECT. Ann Nucl Med 28:812–823

Article  CAS  PubMed  Google Scholar 

Van Kriekinge SD, Nishina H, Ohba M, Berman DS, Germano G (2008) Automatic global and regional phase analysis from gated myocardial perfusion SPECT imaging: application to the characterization of ventricular contraction in patients with left bundle branch block. J Nucl Med 49:1790–1797

Article  PubMed  Google Scholar 

Kuronuma K, Matsumoto N, Van Kriekinge SD, Slomka PJ, Berman DS (2023) Usefulness of phase analysis on ECG gated single photon emission computed tomography myocardial perfusion imaging. J Cardiol 82:87–92

Article  PubMed  Google Scholar 

Tanaka Y, Yoda S, Fukumoto K, Hatta T, Kuronuma K, Suzuki Y, Matsumoto N, Okumura Y (2024) Association between an early revascularization strategy and major cardiac events based on left ventricular dyssynchrony in patients at intermediate risk of major cardiac events using the J-ACCESS risk model. Intern Med 63:2739–2750

Article  PubMed  PubMed Central  Google Scholar 

Zafrir N, Nevzorov R, Bental T, Strasberg B, Gutstein A, Mats I, Kornowski R, Solodky A (2014) Prognostic value of left ventricular dyssynchrony by myocardial perfusion-gated SPECT in patients with normal and abnormal left ventricular functions. J Nucl Cardiol 21:532–540

Article  PubMed  Google Scholar 

Sillanmäki S, Gimelli A, Ahmad S, Samir S, Laitinen T, Soman P (2021) Mechanisms of left ventricular dyssynchrony: A multinational SPECT study of patients with bundle branch block. J Nucl Cardiol 28:1140–1150

Article  PubMed  Google Scholar 

Kuronuma K, Miller RJH, Van Kriekinge SD, Han D, Singh A, Gransar H, Dey D, Berman DS, Slomka PJ (2023) Incremental prognostic value of stress phase entropy over standard PET myocardial perfusion imaging variables. Eur J Nucl Med Mol Imaging 50:3619–3629

Article  PubMed  PubMed Central  Google Scholar 

Legallois D, Marie PY, Franken PR, Djaballah W, Agostini D, Manrique A (2018) Comparison of the dyssynchrony parameters recorded with gated SPECT in ischemic cardiomyopathy according to their repeatability at rest and to their ability to detect a synchrony reserve under dobutamine infusion. J Nucl Cardiol 27:2247–2257

Article  PubMed  Google Scholar 

AlJaroudi W, Jaber WA, Cerqueira MD (2012) Effect of tracer dose on left ventricular mechanical dyssynchrony indices by phase analysis of gated single photon emission computed tomography myocardial perfusion imaging. J Nucl Cardiol 19:63–72

Article  PubMed  Google Scholar 

Gibbons RJ, Chatterjee K, Daley J, Douglas JS, Fihn SD, Gardin JM, Grunwald MA, Levy D, Lytle BW, O’Rourke RA, Schafer WP, Williams SV, Ritchie JL, Cheitlin MD, Eagle KA, Gardner TJ, Garson A Jr, Russell RO, Ryan TJ, Smith SC Jr (1999) ACC/AHA/ACP-ASIM guidelines for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Patients With Chronic Stable Angina). J Am Coll Cardiol 33:2092–2197