Savarese G, Becher PM, Lund LH, Seferovic P, Rosano GMC, Coats AJS (2023) Global burden of heart failure: a comprehensive and updated review of epidemiology. Cardiovasc Res 118:3272–3287

Article  PubMed  Google Scholar 

Shahim B, Kapelios CJ, Savarese G, Lund LH (2023) Global public health burden of heart failure: an updated review. Card Fail Rev 9:e11

Article  PubMed  PubMed Central  Google Scholar 

Sato N (2013) Critical issue in the cardiovascular field: hospitalization for heart failure. J Cardiol 62:140–141

Article  PubMed  Google Scholar 

Murninkas D, Alba AC, Delgado D, McDonald M, Billia F, Chan WS, Ross HJ (2014) Right ventricular function and prognosis in stable heart failure patients. J Card Fail 20:343–349

Article  PubMed  Google Scholar 

Kjaergaard J, Akkan D, Iversen KK, Køber L, Torp-Pedersen C, Hassager C (2007) Right ventricular dysfunction as an independent predictor of short- and long-term mortality in patients with heart failure. Eur J Heart Fail 9:610–616

Article  PubMed  Google Scholar 

Miller WL, Grill DE, Borlaug BA (2013) Clinical features, hemodynamics, and outcomes of pulmonary hypertension due to chronic heart failure with reduced ejection fraction: pulmonary hypertension and heart failure. JACC Heart Fail 1:290–299

Article  PubMed  Google Scholar 

Aronson D, Eitan A, Dragu R, Burger AJ (2011) Relationship between reactive pulmonary hypertension and mortality in patients with acute decompensated heart failure. Circ Heart Fail 4:644–650

Article  PubMed  Google Scholar 

Guazzi M, Bandera F, Pelissero G, Castelvecchio S, Menicanti L, Ghio S, Temporelli PL, Arena R (2013) Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis. Am J Physiol Heart Circ Physiol 305:H1373–H1381

Article  CAS  PubMed  Google Scholar 

Sercelik A, Askin L (2024) The tricuspid annular plane systolic excursion/PASP ratio’s accuracy and validity in assessing the right ventricular function: a narrative review. J Res Med Sci 29:75

PubMed  PubMed Central  Google Scholar 

Schmeisser A, Rauwolf T, Groscheck T, Kropf S, Luani B, Tanev I, Hansen M, Meißler S, Steendijk P, Braun-Dullaeus RC (2021) Pressure-volume loop validation of TAPSE/PASP for right ventricular arterial coupling in heart failure with pulmonary hypertension. Eur Heart J Cardiovasc Imaging 22:168–176

Article  PubMed  Google Scholar 

Riccardi M, Pagnesi M, Corso R, Sammartino AM, Tomasoni D, Inciardi RM, Lombardi CM, Adamo M, Nodari S, Metra M (2025) Prognostic role of TAPSE to PASP ratio in outpatients with left ventricular systolic dysfunction. ESC Heart Fail 12:912–922

Article  PubMed  Google Scholar 

Naseem M, Alkassas A, Alaarag A (2022) Tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure ratio as a predictor of in-hospital mortality for acute heart failure. BMC Cardiovasc Disord 22:414

Article  PubMed  PubMed Central  Google Scholar 

Stolfo D, Fabris E, Lund LH, Savarese G, Sinagra G (2022) From mid-range to mildly reduced ejection fraction heart failure: a call to treat. Eur J Intern Med 103:29–35

Article  PubMed  Google Scholar 

Shang Z, Wang X, Gao W (2022) Heart failure with mildly reduced ejection fraction: emerging frontiers in clinical characteristics, prognosis, and treatment. Rev Cardiovasc Med 23:30

Article  PubMed  Google Scholar 

Steffen HJ, Abel N, Lau F, Schmitt A, Reinhardt M, Akin M, Bertsch T, Rusnak J, Weidner K, Behnes M, Akin I, Schupp T (2025) Timing of acute decompensated heart failure in patients with heart failure and mildly reduced ejection fraction. Heart Vessels. https://doi.org/10.1007/s00380-024-02505-3

Article  PubMed  Google Scholar 

Desai N, Olewinska E, Famulska A, Remuzat C, Francois C, Folkerts K (2024) Heart failure with mildly reduced and preserved ejection fraction: a review of disease burden and remaining unmet medical needs within a new treatment landscape. Heart Fail Rev 29:631–662

Article  PubMed  PubMed Central  Google Scholar 

Savarese G, Stolfo D, Sinagra G, Lund LH (2022) Heart failure with mid-range or mildly reduced ejection fraction. Nat Rev Cardiol 19:100–116

Article  PubMed  Google Scholar 

Miller RJH, Nabipoor M, Youngson E, Kotrri G, Fine NM, Howlett JG, Paterson ID, Ezekowitz J, McAlister FA (2022) Heart failure with mildly reduced ejection fraction: retrospective study of ejection fraction trajectory risk. ESC Heart Fail 9:1564–1573

Article  PubMed  PubMed Central  Google Scholar 

Xanthopoulos A, Giamouzis G, Skoularigis J, Triposkiadis F (2022) Heart failure with reduced, mildly reduced, or preserved left ventricular ejection fraction: has reasoning been lost? World J Cardiol 14:438–445

Article  PubMed  PubMed Central  Google Scholar 

Tsukamoto K, Suzuki A, Shiga T, Arai K, Hagiwara N (2021) Changes in the left ventricular ejection fraction and outcomes in hospitalized heart failure patients with mid-range ejection fraction: a prospective observational study. Intern Med 60:1509–1518

Article  CAS  PubMed  Google Scholar 

Haruki K, Suzuki A, Yoshida A, Ashihara K, Yamaguchi J, Shiga T (2025) Persistently low tricuspid annular plane systolic excursion and its prognosis in Japanese hospitalized patients with heart failure with reduced ejection fraction. Heart Vessels 40:391–404

Article  PubMed  Google Scholar 

Tsutsui H, Ide T, Ito H, Kihara Y, Kinugawa K, Kinugawa S, Makaya M, Murohara T, Node K, Saito Y, Sakata Y, Shimizu W, Yamamoto K, Bando Y, Iwasaki YK, Kinugasa Y, Mizote I, Nakagawa H, Oishi S, Okada A, Tanaka A, Akasaka T, Ono M, Kimura T, Kosaka S, Kosuge M, Momomura SI, Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group (2021) JCS/JHFS 2021 guideline focused update on diagnosis and treatment of acute and chronic heart failure. Circ J 85:2252–2291

Article  CAS  PubMed  Google Scholar 

Writing Committee Members, Douglas PS, Carabello BA, Lang RM, Lopez L, Pellikka PA, Picard MH, Thomas JD, Varghese P, Wang TY, Weissman NJ, Wilgus R, ACC/AHA Task Force on Clinical Data Standards Members, Bozkurt B, Jneid H, Al-Khatib SM, Anderson HV, Gilstrap L, Graham GN, Jones GK, Kao D, Lopez L, Marcus G, Rymer J, Tcheng JE, Weintraub WS (2019) 2019 ACC/AHA/ASE key data elements and definitions for transthoracic echocardiography: a report of the American College of Cardiology/American Heart Association task force on clinical data standards (writing committee to develop clinical data standards for transthoracic echocardiography) and the American Society of Echocardiography. J Am Soc Echocardiogr 32:1161–1248

Article  Google Scholar 

Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1-39.e14

Article  PubMed  Google Scholar 

Bach DS (1996) Quantitative doppler tissue imaging as a correlate of left ventricular contractility. Int J Card Imaging 12:191–195

Article  CAS  PubMed  Google Scholar 

Mukherjee M, Rudski LG, Addetia K, Afilalo J, D’Alto M, Freed BH, Friend LB, Gargani L, Grapsa J, Hassoun PM, Hua L, Kim J, Mercurio V, Saggar R, Vonk-Noordegraaf A (2025) Guidelines for the echocardiographic assessment of the right heart in adults and special considerations in pulmonary hypertension: recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr 38:141–186

Article  PubMed  Google Scholar 

Melenovsky V, Kotrc M, Borlaug BA, Marek T, Kovar J, Malek I, Kautzner J (2013) Relationships between right ventricular function, body composition, and prognosis in advanced heart failure. J Am Coll Cardiol 62:1660–1670

Article  PubMed  Google Scholar 

Tello K, Axmann J, Ghofrani HA, Naeije R, Narcin N, Rieth A, Seeger W, Gall H, Richter MJ (2018) Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension. Int J Cardiol 266:229–235

Article  PubMed  Google Scholar 

Bettencourt P, Ferreira A, Dias P, Pimenta J, Friões F, Martins L, Cerqueira-Gomes M (2000) Predictors of prognosis in patients with stable mild to moderate heart failure. J Card Fail 6:306–313

Article  CAS  PubMed  Google Scholar