Intravenous thrombolysis with tenecteplase versus alteplase in acute ischemic stroke tandem occlusions: a systematic review and meta-analysis of current available literature

Jadhav AP, Zaidat OO, Liebeskind DS et al (2019) Emergent management of tandem lesions in acute ischemic stroke. Stroke 50:428–433

Article  PubMed  Google Scholar 

Feil K, Herzberg M, Dorn F et al (2021) Tandem lesions in anterior circulation stroke: analysis of the German stroke registry-endovascular treatment. Stroke 52(4):1265–1275

Article  CAS  PubMed  Google Scholar 

Anadani M, Marnat G, Consoli A et al (2022) Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion. J Neurointerv Surg 14:314–320

Article  PubMed  Google Scholar 

Papanagiotou P, Haussen DC, Turjman F et al (2018) Carotid stenting with antithrombotic agents and intracranial thrombectomy leads to the highest recanalization rate in patients with acute stroke with tandem lesions. JACC Cardiovasc Interv 11:1290–1299

Article  PubMed  Google Scholar 

Turc G, Tsivgoulis G, Audebert HJ et al (2022) European Stroke Organisation—European Society for Minimally Invasive Neurological Therapy expedited recommendation on indication for intravenous thrombolysis before mechanical thrombectomy in patients with acute ischaemic stroke and anterior circulation large vessel occlusion. Eur Stroke J 7:XXVI

Article  Google Scholar 

Bracard S, Ducrocq X, Mas JL et al (2016) Mechanical thrombectomy after intravenous alteplase versus alteplase alone after stroke (THRACE): a randomised controlled trial. Lancet Neurol 15:1138–1147

Article  CAS  PubMed  Google Scholar 

Poppe AY, Jacquin G, Roy D, Stapf C, Derex L (2020) Tandem carotid lesions in acute ischemic stroke: mechanisms, therapeutic challenges, and future directions. AJNR Am J Neuroradiol 41(7):1142–1148

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yogendrakumar V, Churilov L, Mitchell PJ et al (2023) Safety and efficacy of tenecteplase and alteplase in patients with tandem lesion stroke: a post hoc analysis of the EXTEND-IA TNK trials. Neurology 100:e1911

Article  Google Scholar 

Marnat G, Lapergue B, Gory B et al (2024) Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: a pooled analysis of ETIS and TETRIS. Eur Stroke J 9(1):124–134. https://doi.org/10.1177/23969873231206894

Article  PubMed  Google Scholar 

Bala F, Almekhlafi M, Singh N et al (2024) Safety and efficacy of tenecteplase versus alteplase in stroke patients with carotid tandem lesions: results from the AcT trial. Int J Stroke 19(3):322–330. https://doi.org/10.1177/17474930231205208

Article  PubMed  Google Scholar 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2023) Cochrane handbook for systematic reviews of interventions version 6.4 (updated August 2023). Cochrane, 2023. www.training.cochrane.org/handbook.

Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. https://doi.org/10.1371/journal.pmed.1000097

Article  PubMed  PubMed Central  Google Scholar 

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR, Chan AW, Churchill R, Deeks JJ, Hróbjartsson A, Kirkham J, Jüni P, Loke YK, Pigott TD, Ramsay CR, Regidor D, Rothstein HR, Sandhu L, Santaguida PL, Schünemann HJ, Shea B, Shrier I, Tugwell P, Turner L, Valentine JC, Waddington H, Waters E, Wells GA, Whiting PF, Higgins JP (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. https://doi.org/10.1136/bmj.i4919

Article  PubMed  PubMed Central  Google Scholar 

Sterne JAC, Savović J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. https://doi.org/10.1136/bmj.l4898

Article  PubMed  PubMed Central  Google Scholar 

Di Donna A, Muto G, Giordano F et al (2023) Diagnosis and management of tandem occlusion in acute ischemic stroke. Eur J Radiol Open 11:100513. https://doi.org/10.1016/j.ejro.2023.100513

Article  PubMed  PubMed Central  Google Scholar 

Catanese L, Shoamanesh A, Poppe AY (2021) Tandem occlusions. Stroke 52(10):3106–3108. https://doi.org/10.1161/STROKEAHA.121.036219

Article  PubMed  Google Scholar 

Rodriguez-Calienes A, Galecio-Castillo M, Farooqui M et al (2023) Safety outcomes of mechanical thrombectomy versus combined thrombectomy and intravenous thrombolysis in tandem lesions. Stroke 54(10):2522–2533. https://doi.org/10.1161/STROKEAHA.123.042966

Article  PubMed  PubMed Central  Google Scholar 

Li G, Wang C, Wang S, Xiong Y, Zhao X (2022) Tenecteplase in ischemic stroke: challenge and opportunity. Neuropsychiatr Dis Treat 18:1013–1026. https://doi.org/10.2147/NDT.S360967

Article  PubMed  PubMed Central  Google Scholar 

Tsivgoulis G, Katsanos AH, Sandset EC et al (2023) Thrombolysis for acute ischaemic stroke: current status and future perspectives. Lancet Neurol 22(5):418–429. https://doi.org/10.1016/S1474-4422(22)00519-1

Article  CAS  PubMed  Google Scholar 

Wang L, Hao M, Wu N, Wu S, Fisher M, Xiong Y (2024) Comprehensive review of tenecteplase for thrombolysis in acute ischemic stroke. J Am Heart Assoc. https://doi.org/10.1161/JAHA.123.031692

Article  PubMed  PubMed Central  Google Scholar 

Campbell BCV, Mitchell PJ, Churilov L et al (2018) Tenecteplase versus alteplase before thrombectomy for ischemic stroke. N Engl J Med 378(17):1573–1582. https://doi.org/10.1056/NEJMoa1716405

Article  CAS  PubMed  Google Scholar 

Baruah DB, Dash RN, Chaudhari MR, Kadam SS (2006) Plasminogen activators: a comparison. Vascul Pharmacol 44(1):1–9. https://doi.org/10.1016/j.vph.2005.09.003

Article  CAS  PubMed  Google Scholar 

Yaghi S, Willey JZ, Cucchiara B et al (2017) Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke: a scientific statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. https://doi.org/10.1161/STR.0000000000000152

Article  PubMed  PubMed Central  Google Scholar 

Robinson T, Zaheer Z, Mistri AK (2011) Thrombolysis in acute ischaemic stroke: an update. Ther Adv Chronic Dis 2(2):119–131. https://doi.org/10.1177/2040622310394032

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif