Wang L, Peng W, Zhao Z, Zhang M, Shi Z, Song Z, Zhang X, Li C, Huang Z, Sun X, Wang L, Zhou M, Wu J, Wang Y (2021) Prevalence and treatment of diabetes in China, 2013–2018. JAMA 326:2498–2506. https://doi.org/10.1001/jama.2021.22208

Article  PubMed  PubMed Central  Google Scholar 

Nagy B, Jin J, Ashby B, Reilly MP, Kunapuli SP (2011) Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia. J Thromb Haemost 9:810–819. https://doi.org/10.1111/j.1538-7836.2011.04217.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Handtke S, Thiele T (2020) Large and small platelets-(When) do they differ? J Thromb Haemost 18:1256–1267. https://doi.org/10.1111/jth.14788

Article  PubMed  Google Scholar 

Yun J-S, Ko S-H (2021) Current trends in epidemiology of cardiovascular disease and cardiovascular risk management in type 2 diabetes. Metabolism 123:154838. https://doi.org/10.1016/j.metabol.2021.154838

Article  PubMed  CAS  Google Scholar 

Giannella A, Ceolotto G, Radu CM, Cattelan A, Iori E, Benetti A, Fabris F, Simioni P, Avogaro A, Vigili de Kreutzenberg S (2021) PAR-4/Ca-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes. Cardiovasc Diabetol 20:77. https://doi.org/10.1186/s12933-021-01267-w

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cirino G, Szabo C, Papapetropoulos A (2023) Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol Rev 103:31–276. https://doi.org/10.1152/physrev.00028.2021

Article  PubMed  CAS  Google Scholar 

Jain SK, Bull R, Rains JL, Bass PF, Levine SN, Reddy S, McVie R, Bocchini JA (2010) Low levels of hydrogen sulfide in the blood of diabetes patients and streptozotocin-treated rats causes vascular inflammation? Antioxid Redox Signal 12:1333–1337. https://doi.org/10.1089/ars.2009.2956

Article  PubMed  PubMed Central  CAS  Google Scholar 

Whiteman M, Gooding KM, Whatmore JL, Ball CI, Mawson D, Skinner K, Tooke JE, Shore AC (2010) Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide. Diabetologia 53:1722–1726. https://doi.org/10.1007/s00125-010-1761-5

Article  PubMed  CAS  Google Scholar 

Olas B (2015) Gasomediators (·NO, CO, and H₂S) and their role in hemostasis and thrombosis. Clin Chim Acta 445:115–121. https://doi.org/10.1016/j.cca.2015.03.027

Article  PubMed  CAS  Google Scholar 

Morel A, Malinowska J, Olas B (2012) Antioxidative properties of hydrogen sulfide may involve in its antiadhesive action on blood platelets. Clin Biochem 45:1678–1682. https://doi.org/10.1016/j.clinbiochem.2012.08.025

Article  PubMed  CAS  Google Scholar 

Grambow E, Leppin C, Leppin K, Kundt G, Klar E, Frank M, Vollmar B (2017) The effects of hydrogen sulfide on platelet-leukocyte aggregation and microvascular thrombolysis. Platelets 28:509–517. https://doi.org/10.1080/09537104.2016.1235693

Article  PubMed  CAS  Google Scholar 

d’Emmanuele di Villa, Bianca R, Mitidieri E, Di Minno MND, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R (2013) Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. Proc Natl Acad Sci U S A 110:15812–15817. https://doi.org/10.1073/pnas.1309049110

Article  Google Scholar 

Ding H, Chang J, He F, Gai S, Yang P (2022) Hydrogen sulfide: an emerging Precision Strategy for Gas Therapy. Adv Healthc Mater 11:e2101984. https://doi.org/10.1002/adhm.202101984

Article  PubMed  CAS  Google Scholar 

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Hilliard ME, Isaacs D, Johnson EL, Kahan S, Khunti K, Leon J, Lyons SK, Perry ML, Prahalad P, Pratley RE, Seley JJ, Stanton RC, Gabbay RA (2023) On behalf of the American Diabetes A. 2. Classification and diagnosis of diabetes: standards of Care in Diabetes-2023. Diabetes Care 46:S19–S40. https://doi.org/10.2337/dc23-S002

Article  PubMed  CAS  Google Scholar 

Li L, Qu C, Wu X, Dai J, Lu Y, Gong Y, You R, Liu Y (2018) Patterns and levels of platelet glycosylation in patients with coronary heart disease and type 2 diabetes mellitus. J Thromb Thrombolysis 45:56–65. https://doi.org/10.1007/s11239-017-1573-2

Article  PubMed  CAS  Google Scholar 

Huang P, Chen S, Wang Y, Liu J, Yao Q, Huang Y, Li H, Zhu M, Wang S, Li L, Tang C, Tao Y, Yang G, Du J, Jin H (2015) Down-regulated CBS/H2S pathway is involved in high-salt-induced hypertension in Dahl rats. Nitric Oxide 46:192–203. https://doi.org/10.1016/j.niox.2015.01.004

Article  PubMed  CAS  Google Scholar 

Li L, Qu C, Lu Y, Gong Y, You R, Miao L, Guo S (2019) The platelet surface glycosylation caused by glycosidase has a strong impact on platelet function. Blood Coagul Fibrinolysis 30:217–223. https://doi.org/10.1097/MBC.0000000000000826

Article  PubMed  CAS  Google Scholar 

Ju L, McFadyen JD, Al-Daher S, Alwis I, Chen Y, Tønnesen LL, Maiocchi S, Coulter B, Calkin AC, Felner EI, Cohen N, Yuan Y, Schoenwaelder SM, Cooper ME, Zhu C, Jackson SP (2018) Compression force sensing regulates integrin αβ adhesive function on diabetic platelets. Nat Commun 9:1087. https://doi.org/10.1038/s41467-018-03430-6

Article  PubMed  PubMed Central  CAS  Google Scholar 

Storey RF, Parker WAE (2016) Choices for potent platelet inhibition in patients with diabetes Mellitus. Circulation 134:793–796. https://doi.org/10.1161/CIRCULATIONAHA.116.023835

Article  PubMed  Google Scholar 

Patti G, Cavallari I, Andreotti F, Calabrò P, Cirillo P, Denas G, Galli M, Golia E, Maddaloni E, Marcucci R, Parato VM, Pengo V, Prisco D, Ricottini E, Renda G, Santilli F, Simeone P, De Caterina R (2019) Prevention of atherothrombotic events in patients with diabetes mellitus: from antithrombotic therapies to new-generation glucose-lowering drugs. Nat Rev Cardiol 16:113–130. https://doi.org/10.1038/s41569-018-0080-2

Article  PubMed  CAS  Google Scholar 

Michelson AD, Barnard MR, Krueger LA, Valeri CR, Furman MI (2001) Circulating monocyte-platelet aggregates are a more sensitive marker of in vivo platelet activation than platelet surface P-selectin: studies in baboons, human coronary intervention, and human acute myocardial infarction. Circulation 104:1533–1537

Article  PubMed  CAS  Google Scholar 

Pluta K, Porębska K, Urbanowicz T, Gąsecka A, Olasińska-Wiśniewska A, Targoński R, Krasińska A, Filipiak KJ, Jemielity M, Krasiński Z (2022) Platelet-leucocyte aggregates as novel biomarkers in Cardiovascular diseases. Biology (Basel) 11:224. https://doi.org/10.3390/biology11020224

Article  PubMed  CAS  Google Scholar 

Patkó Z, Császár A, Acsády G, Ory I, Takács E, Fűrész J (2012) Elevation of monocyte-platelet aggregates is an early marker of type 2 diabetes. Interv Med Appl Sci 4:181–185. https://doi.org/10.1556/IMAS.4.2012.4.2

Article  PubMed  PubMed Central  Google Scholar 

Elalamy I, Chakroun T, Gerotziafas GT, Petropoulou A, Robert F, Karroum A, Elgrably F, Samama MM, Hatmi M (2008) Circulating platelet-leukocyte aggregates: a marker of microvascular injury in diabetic patients. Thromb Res 121:843–848

Article  PubMed  CAS  Google Scholar 

Allen N, Barrett TJ, Guo Y, Nardi M, Ramkhelawon B, Rockman CB, Hochman JS, Berger JS (2019) Circulating monocyte-platelet aggregates are a robust marker of platelet activity in cardiovascular disease. Atherosclerosis 282:11–18. https://doi.org/10.1016/j.atherosclerosis.2018.12.029

Article  PubMed  CAS  Google Scholar 

Li N, Hu H, Hjemdahl P (2003) Aspirin treatment does not attenuate platelet or leukocyte activation as monitored by whole blood flow cytometry. Thromb Res 111:165–170

Article  PubMed  CAS  Google Scholar 

Schuerholz T, Lösche W, Keil O, Friedrich L, Simon T-P, Marx G (2008) Acute short-term hyperglycemia impairs platelet receptor expression even in healthy adults in vitro. Med Sci Monit 14:BR294–BR8

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