Abramson DH (2022) Cell free DNA (cfDNA) in the blood of retinoblastoma patients the Robert M. Ellsworth lecture. Ophthalmic Genet 43(6):731–735. https://doi.org/10.1080/13816810.2021.2004433

Article  PubMed  PubMed Central  CAS  Google Scholar 

Alonso-Herranz L, Albarrán-Juárez J, Bentzon JF (2023) Mechanisms of fibrous cap formation in atherosclerosis. Front Cardiovasc Med 10:1254114. https://doi.org/10.3389/fcvm.2023.1254114

Article  PubMed  PubMed Central  CAS  Google Scholar 

Angert RM, Leshane ES, Yarnell RW, Johnson KL, Bianchi DW (2004) Cell-free fetal DNA in the cerebrospinal fluid of women during the peripartum period. Am J Obstet Gynecol 190(4):1087–1090. https://doi.org/10.1016/j.ajog.2003.10.562

Article  PubMed  CAS  Google Scholar 

Antiochos B, Trejo-Zambrano D, Fenaroli P, Rosenberg A, Baer A, Garg A, Sohn J, Li J, Petri M, Goldman DW, Mecoli C, Casciola-Rosen L, Rosen A (2022) The DNA sensors AIM2 and IFI16 are SLE autoantigens that bind neutrophil extracellular traps. eLife 11:e72103. https://doi.org/10.7554/eLife.72103

Article  PubMed  PubMed Central  CAS  Google Scholar 

Arkelius K, Wendt TS, Andersson H, Arnou A, Gottschalk M, Gonzales RJ, Ansar S (2024) LOX-1 and MMP-9 inhibition attenuates the detrimental effects of delayed rt-PA therapy and improves outcomes after acute ischemic stroke. Circ Res 134(8):954–969. https://doi.org/10.1161/CIRCRESAHA.123.323371

Article  PubMed  CAS  Google Scholar 

Aubert O, Ursule-Dufait C, Brousse R, Gueguen J, Racapé M, Raynaud M, Van Loon E, Pagliazzi A, Huang E, Jordan SC, Chavin KD, Gupta G, Kumar D, Alhamad T, Anand S, Sanchez-Garcia J, Abdalla BA, Hogan J, Garro R, Loupy A (2024) Cell-free DNA for the detection of kidney allograft rejection. Nat Med 30(8):2320–2327. https://doi.org/10.1038/s41591-024-03087-3

Article  PubMed  PubMed Central  CAS  Google Scholar 

Balusu S, Van Wonterghem E, De Rycke R, Raemdonck K, Stremersch S, Gevaert K, Brkic M, Demeestere D, Vanhooren V, Hendrix A, Libert C, Vandenbroucke RE (2016) Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles. EMBO Mol Med 8(10):1162–1183. https://doi.org/10.15252/emmm.201606271

Article  PubMed  PubMed Central  CAS  Google Scholar 

Baumann T, de Buhr N, Blume N, Gabriel MM, Ernst J, Fingerhut L, Imker R, Abu-Fares O, Kühnel M, Jonigk DD, Götz F, Falk C, Weissenborn K, Grosse GM, Schuppner R (2024) Assessment of associations between neutrophil extracellular trap biomarkers in blood and thrombi in acute ischemic stroke patients. J Thromb Thrombolysis 57(6):936–946. https://doi.org/10.1007/s11239-024-03004-y

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bendszus M, Fiehler J, Subtil F, Bonekamp S, Aamodt AH, Fuentes B, Gizewski ER, Hill MD, Krajina A, Pierot L, Simonsen CZ, Zeleňák K, Blauenfeldt RA, Cheng B, Denis A, Deutschmann H, Dorn F, Flottmann F, Gellißen S, Zubel S (2023) Endovascular thrombectomy for acute ischaemic stroke with established large infarct: multicentre, open-label, randomised trial. Lancet 402(10414):1753–1763. https://doi.org/10.1016/S0140-6736(23)02032-9

Article  PubMed  Google Scholar 

Bhatia K, Ahmad S, Kindelin A, Ducruet AF (2021) Complement C3a receptor-mediated vascular dysfunction: a complex interplay between aging and neurodegeneration. J Clin Invest 131(1):e144348. https://doi.org/10.1172/JCI144348

Article  PubMed  PubMed Central  CAS  Google Scholar 

Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BLJH (2013) Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state. Arterioscler Thromb Vasc Biol 33(8):2032–2040. https://doi.org/10.1161/ATVBAHA.113.301627

Article  PubMed  PubMed Central  CAS  Google Scholar 

Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD (2012) Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost 10(1):136–144. https://doi.org/10.1111/j.1538-7836.2011.04544.x

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bronkhorst AJ, Ungerer V, Diehl F, Anker P, Dor Y, Fleischhacker M, Gahan PB, Hui L, Holdenrieder S, Thierry AR (2021) Towards systematic nomenclature for cell-free DNA. Hum Genet 140(4):565–578. https://doi.org/10.1007/s00439-020-02227-2

Article  PubMed  CAS  Google Scholar 

Broz P, Dixit VM (2016) Inflammasomes: mechanism of assembly, regulation and signalling. Nat Rev Immunol 16(7):407–420. https://doi.org/10.1038/nri.2016.58

Article  PubMed  CAS  Google Scholar 

Cai W, Liu S, Hu M, Huang F, Zhu Q, Qiu W, Hu X, Colello J, Zheng SG, Lu Z (2020) Functional dynamics of neutrophils after ischemic stroke. Transl Stroke Res 11(1):108–121. https://doi.org/10.1007/s12975-019-00694-y

Article  PubMed  Google Scholar 

Campbell BCV, Khatri P (2020) Stroke. Lancet 396(10244):129–142. https://doi.org/10.1016/S0140-6736(20)31179-X

Article  PubMed  Google Scholar 

Candelario-Jalil E, Dijkhuizen RM, Magnus T (2022) Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities. Stroke 53(5):1473–1486. https://doi.org/10.1161/STROKEAHA.122.036946

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cao J, Roth S, Zhang S, Kopczak A, Mami S, Asare Y, Georgakis MK, Messerer D, Horn A, Shemer R, Jacqmarcq C, Picot A, Green JP, Schlegl C, Li X, Tomas L, Dutsch A, Liman TG, Endres M, Liesz A (2024) DNA-sensing inflammasomes cause recurrent atherosclerotic stroke. Nature 633(8029):433–441. https://doi.org/10.1038/s41586-024-07803-4

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cardelli M, Marchegiani F, Stripoli P, Piacenza F, Recchioni R, Di Rosa M, Giacconi R, Malavolta M, Galeazzi R, Arosio B, Cafarelli F, Spannella F, Cherubini A, Lattanzio F, Olivieri F (2024) Plasma CfDNA abundance as a prognostic biomarker for higher risk of death in geriatric cardiovascular patients. Mech Ageing Dev 219:111934. https://doi.org/10.1016/j.mad.2024.111934

Article  PubMed  CAS  Google Scholar 

Chakravadhanula M, Tembe W, Legendre C, Carpentieri D, Liang WS, Bussey KJ, Carpten J, Berens ME, Bhardwaj RD (2014) Detection of an atypical teratoid rhabdoid brain tumor gene deletion in circulating blood using next-generation sequencing. J Child Neurol 29(9):NP81-85. https://doi.org/10.1177/0883073813503904

Article  PubMed  Google Scholar 

Chen J, Hou S, Liang Q, He W, Li R, Wang H, Zhu Y, Zhang B, Chen L, Dai X, Zhang T, Ren J, Duan H (2022) Localized degradation of neutrophil extracellular traps by photoregulated enzyme delivery for cancer immunotherapy and metastasis suppression. ACS Nano 16(2):2585–2597. https://doi.org/10.1021/acsnano.1c09318

Article  PubMed  CAS  Google Scholar 

Chen X-Q, Tu L, Tang Q, Zou J-S, Yun X, Qin Y-H (2023) DNase I targeted degradation of neutrophil extracellular traps to reduce the damage on IgAV rat. PLoS One 18(10):e0291592. https://doi.org/10.1371/journal.pone.0291592

Article  PubMed  PubMed Central  CAS  Google Scholar 

Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, Kelly MM, Patel KD, Chakrabarti S, McAvoy E, Sinclair GD, Keys EM, Allen-Vercoe E, Devinney R, Doig CJ, Green FHY, Kubes P (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13(4):463–469. https://doi.org/10.1038/nm1565

Article  PubMed  CAS  Google Scholar 

Coates-Park S, Lazaroff C, Gurung S, Rich J, Colladay A, O’Neill M, Butler GS, Overall CM, Stetler-Stevenson WG, Peeney D (2023) Tissue inhibitors of metalloproteinases are proteolytic targets of matrix metalloproteinase 9. Matrix Biology: J Int Soc Matrix Biology 123:59–70. https://doi.org/10.1016/j.matbio.2023.09.002

Article  CAS  Google Scholar 

Dao J, Conway PJ, Subramani B, Meyyappan D, Russell S, Mahadevan D (2023) Using CfDNA and ctdna as oncologic markers: a path to clinical validation. Int J Mol Sci 24(17):13219. https://doi.org/10.3390/ijms241713219

Article