Martinelli I (2001) Risk factors in venous thromboembolism. Thromb Haemost 86(07):395–403
Article CAS PubMed Google Scholar
Castoldi E et al (2021) Severe thrombophilia in a factor V-deficient patient homozygous for the Ala2086Asp mutation (FV Besançon). J Thromb Haemost 19(5):1186–1199
Article CAS PubMed Google Scholar
Elkattawy S et al (2022) Prothrombin G20210A gene mutation-induced recurrent deep vein thrombosis and pulmonary embolism: case report and literature review. J Investig Med High Impact Case Rep 10:23247096211058486
Article PubMed PubMed Central Google Scholar
Emmerich J et al (2001) Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism. Thromb Haemost 86(09):809–816
Article CAS PubMed Google Scholar
Poort SR et al (1996) A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
Rees DC, Cox M, Clegg JB (1995) World distribution of factor V Leiden. Lancet (London England) 346(8983):1133–1134
Article CAS PubMed Google Scholar
Rosendaal F, Reitsma P (2009) Genetics of venous thrombosis. J Thromb Haemost 7:301–304
Article CAS PubMed Google Scholar
Kujovich JL (2011) Factor v Leiden Thrombophilia. Genet Sci 13(1):1–16
Rosen E et al (1999) High frequency of factor V Leiden in a population of Israeli arabs. Thromb Haemost 82(12):1768–1768
Article CAS PubMed Google Scholar
Zivelin A et al (1998) A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene. Blood J Am Soc Hematol 92(4):1119–1124
Gómez-Outes A et al (2012) Discovery of anticoagulant drugs: a historical perspective. Curr Drug Discov Technol 9(2):83–104
Zöller B et al (1994) Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Investig 94(6):2521–2524
Article PubMed PubMed Central Google Scholar
Ryu J et al (2024) Thrombosis risk in single-and double-heterozygous carriers of factor V Leiden and prothrombin G20210A in FinnGen and the UK Biobank. Blood 143(23):2425–2432
Article CAS PubMed Google Scholar
Ho WK et al (2006) Risk of recurrent venous thromboembolism in patients with common thrombophilia: a systematic review. Arch Intern Med 166(7):729–736
Article CAS PubMed Google Scholar
Simioni P et al (2000) Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis. Blood J Am Soc Hematol 96(10):3329–3333
Agnelli G et al (2013) Oral apixaban for the treatment of acute venous thromboembolism. N Engl J Med 369(9):799–808
Article CAS PubMed Google Scholar
Chen A, Stecker E, Warden BA (2020) Direct oral anticoagulant use: a practical guide to common clinical challenges. J Am Heart Association 9(13):e017559
Investigators E (2010) Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 363(26):2499–2510
Investigators H-V (2013) Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism. N Engl J Med 369(15):1406–1415
Schulman S et al (1997) The duration of oral anticoagulant therapy after a second episode of venous thromboembolism. N Engl J Med 336(6):393–398
Article CAS PubMed Google Scholar
Schulman S et al (2009) Dabigatran versus warfarin in the treatment of acute venous thromboembolism. N Engl J Med 361(24):2342–2352
Article CAS PubMed Google Scholar
Arora P et al (2017) Use of direct oral anticoagulants in inherited Thrombophilia. Blood 130:3724
Skelley JW, White CW, Thomason AR (2017) The use of direct oral anticoagulants in inherited thrombophilia. J Thromb Thrombolysis 43(1):24–30
Article CAS PubMed Google Scholar
Zuk J et al (2021) Direct oral anticoagulants in patients with severe inherited thrombophilia: a single-center cohort study. Int J Hematol 113:190–198
Article CAS PubMed Google Scholar
van Es N et al (2014) Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood J Am Soc Hematol 124(12):1968–1975
Pikovsky O et al (2020) Congenital thrombotic thrombocytopenic purpura in a large cohort of patients carrying a novel mutation in ADAMTS13 gene. Thromb Res 185:167–170
Article CAS PubMed Google Scholar
Ageno W et al (2013) The diagnosis of symptomatic recurrent pulmonary embolism and deep vein thrombosis: guidance from the SSC of the ISTH. J Thromb Haemost 11(8):1597–1602
Article CAS PubMed Google Scholar
Konstantinides SV et al (2020) 2019 ESC guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) the Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). Eur Heart J 41(4):543–603
Kaatz S et al (2015) Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non‐surgical patients: communication from the SSC of the ISTH. J Thromb Haemost 13(11):2119–2126
Article CAS PubMed Google Scholar
Rosendaal F et al (1993) A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 69(03):236–239
Article CAS PubMed Google Scholar
Al-Otaiby M et al (2021) The prevalence of Factor V Leiden (Arg506Gln) mutation in King Khalid University Hospital patients, 2017–2019. Nagoya J Med Sci 83(3):407
CAS PubMed PubMed Central Google Scholar
Margaglione M et al (2020) Anticoagulation in Italian patients with venous thromboembolism and thrombophilic alterations: findings from START2 register study. Blood Transfus 18(6):486
PubMed PubMed Central Google Scholar
Serrao A et al (2019) Direct oral anticoagulants in patients affected by major congenital thrombophilia. Mediterranean J Hematol Infect Dis, 11(1)
Undas A, Goralczyk T (2017) Non-vitamin K antagonist oral anticoagulants in patients with severe inherited thrombophilia: a series of 33 patients. Blood Coagul Fibrinolysis 28(6):438–442
Article CAS PubMed Google Scholar
Campello E et al (2020) Direct oral anticoagulants in patients with inherited thrombophilia and venous thromboembolism: a prospective cohort study. J Am Heart Association 9(23):e018917
Coleman CI et al (2018) Effectiveness and safety of outpatient rivaroxaban versus warfarin for treatment of venous thromboembolism in patients with a known primary hypercoagulable state. Thromb Res 163:132–137
Article CAS PubMed Google Scholar
Elsebaie MA et al (2019) Direct oral anticoagulants in patients with venous thromboembolism and thrombophilia: a systematic review and meta-analysis. J Thromb Haemost 17(4):645–656
Giustozzi M et al (2019) Safety of direct oral anticoagulants versus traditional anticoagulants in venous thromboembolism. J Thr
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