Association between apical periodontitis and brain inflammation: a systematic review from animals and human studies

Hunter W. Oral sepsis as a cause of disease. BMJ. 1900;2(2065):215–6. https://doi.org/10.1136/bmj.2.2065.215.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim J, Amar S. Periodontal disease and systemic conditions: a bidirectional relationship. Odontology. 2006;94(1):10–21. https://doi.org/10.1007/s10266-006-0060-6.

Article  PubMed  PubMed Central  Google Scholar 

Bui FQ, Almeida-da-Silva CL, Huynh B, Trinh A, Liu J, Woodward J, et al. Association between periodontal pathogens and systemic disease. Biomed J. 2019;42(1):27–35. https://doi.org/10.1016/j.bj.2018.12.001.

Article  PubMed  PubMed Central  Google Scholar 

Conti LC, Segura-Egea JJ, Cardoso CBM, Benetti F, Azuma MM, Oliveira PHC, et al. Relationship between apical periodontitis and atherosclerosis in rats: lipid profile and histological study. Int Endodontic J. 2020;53(10):1387–97. https://doi.org/10.1111/iej.13350.

Article  CAS  Google Scholar 

Gomes-Filho IS, Cruz SSD, Trindade SC, Passos-Soares JS, Carvalho-Filho PC, Figueiredo ACMG, et al. Periodontitis and respiratory diseases: A systematic review with meta-analysis. Oral Dis. 2020;26(2):439–46. https://doi.org/10.1111/odi.13228.

Article  PubMed  Google Scholar 

Sansores-España LD, Melgar-Rodríguez S, Olivares-Sagredo K, Cafferata EA, Martínez-Aguilar VM, Vernal R, Paula-Lima, et al. Oral-Gut-Brain Axis in Experimental Models of Periodontitis: Associating Gut Dysbiosis With Neurodegenerative Diseases. Front Aging. 2020;2:781582.

Article  Google Scholar 

Howait M, Albassam A, Yamada C, Sasaki H, Bahammam L, Azuma MM, et al. Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis. J Immunol. 2019;202(7):2035–43. https://doi.org/10.4049/jimmunol.1801161.

Article  CAS  PubMed  Google Scholar 

Pereira RF, Cintra LTA, Tessarin GWL, Chiba FY, de Lima Coutinho Mattera MS, Scaramele NF, et al. Periapical Lesions Increase Macrophage Infiltration and Inflammatory Signaling in Muscle Tissue of Rats. J Endodontics. 2017;43(6):982–8.

Article  Google Scholar 

Dos Santos RMD, Machado NEDS, Cantiga-Silva C, Belardi BE, Tsosura TVS, Chiba FY, et al. Modulatory influence of melatonin on apical periodontitis in Wistar rats fed a high-fat diet. Arch Oral Biol. 2023;153: 105749. https://doi.org/10.1016/j.archoralbio.2023.105749.

Article  CAS  PubMed  Google Scholar 

Tompkins KA. The osteoimmunology of alveolar bone loss. Connect Tissue Res. 2016;57(2):69–90. https://doi.org/10.3109/03008207.2016.1140152.

Article  CAS  PubMed  Google Scholar 

Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endodontic Jornal. 2021;54(5):712–35. https://doi.org/10.1111/iej.13467.

Article  Google Scholar 

Gorji A. Neuroinflammation: the pathogenic mechanism of neurological disorders. Int J Mol Sci. 2022;23(10):5744. https://doi.org/10.3390/ijms23105744.

Article  PubMed  PubMed Central  Google Scholar 

Bersano A, Engele J, Schäfer M. Neuroinflammation and brain disease. BMC Neurol. 2023;23(1):227.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nair PN. Pathogenesis of apical periodontitis and the causes of endodontic failures. Critical Rev Oral Biol Med: an Official Publication Am Association Oral Biologists. 2004;15(6):348–81. https://doi.org/10.1177/154411130401500604.

Article  CAS  Google Scholar 

Lisboa ECC, Silva WO, Rodrigues RCV, Brum SC, Alves FRF. The connection between brain abscess and odontogenic infections: A systematic review. Arch Oral Biol. 2022;135: 105360. https://doi.org/10.1016/j.archoralbio.2022.105360.

Article  PubMed  Google Scholar 

Brouwer MC, Tunkel AR, van de Beek D. Brain abscess. N Engl J Med. 2014;371(18):1758. https://doi.org/10.1056/NEJMc1410501.

Article  PubMed  Google Scholar 

Ye L, Cao L, Song W, Yang C, Tang Q, Yuan Z. Interaction between apical periodontitis and systemic disease (Review). Int J Mol Med. 2023;52(1):60. https://doi.org/10.3892/ijmm.2023.5263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hajishengallis G, Chavakis T. Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities. Nat Rev Immunol. 2021;21(7):426–40. https://doi.org/10.1038/s41577-020-00488-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: he PRISMA statement. PLoS Med. 2009;6(7):e1000097.

Article  Google Scholar 

Takahashi S, Segoe H, Kikuiri T, Maruo Y, Sato T, Watanabe Y, et al. A rare case of multiple brain abscesses caused by apical periodontitis of deciduous teeth in congenital heart disease: a case report. BMC Oral Health. 2022;22(1):261. https://doi.org/10.1186/s12903-022-02294-z.

Article  PubMed  PubMed Central  Google Scholar 

Pereira RS, Guerra RC, Hochuli-Vieira E, Alves FRF. Cavernous sinus thrombosis followed by brain ischaemia in a type-1 diabetic patient: a persistent endodontic infection report. Australian Endodontic J. 2022;48(3):510–4.

Article  Google Scholar 

Sukkul P, Kasemsap N. Lemierre’s syndrome with cavernous sinus thrombosis caused by dental infection. BMJ case Rep. 2021;14(3): e238521. https://doi.org/10.1136/bcr-2020-238521.

Article  PubMed  PubMed Central  Google Scholar 

Koseki M, Cammack I, Matsuzaka S. An elderly woman with a bone destructing intracranial epidural abscess caused by apical periodontitis. Abstracts from the 2020 annual meeting of the society of general internal medicine. J Gen Intern Med. 2020;35(1):S1–779.

Google Scholar 

Kichenbrand C, Marchal A, Mouraret A, Hasnaoui N, Guillet J, Rech F, et al. Brain abscesses and intracranial empyema due to dental pathogens: Case series. Int J Surg Case Rep. 2020;69:35–8. https://doi.org/10.1016/j.ijscr.2020.03.025.

Article  PubMed  PubMed Central  Google Scholar 

Basyuni S, Sharma V, Santhanam V, Ferro A. Fatal thalamic abscess secondary to dental infection. BMJ Case Rep. 2015. https://doi.org/10.1136/bcr-2015-212589.

Article  PubMed  PubMed Central  Google Scholar 

Jose A, Nagori SA, Bhutia O, Roychoudhury A. Odontogenic infection and pachymeningitis of the cavernous sinus. Br J Oral Maxillofac Surg. 2014;52(6):e27–9. https://doi.org/10.1016/j.bjoms.2014.03.005.

Article  PubMed  Google Scholar 

Levine M. Understanding how a dental infection may spread to the brain: case report. J (Canadian Dental Association). 2013;79: d9.

Google Scholar 

Taniguchi Y, Ouhara K, Kitagawa M, Akutagawa K, Kawada-Matsuo M, Tamura T, et al. Periapical lesion following Cnm-positive Streptococcus mutans pulp infection worsens cerebral hemorrhage onset in an SHRSP rat model. Clin Exp Immunol. 2022;210(3):321–30. https://doi.org/10.1093/cei/uxac094.

Article  PubMed  PubMed Central  Google Scholar 

Simões LR, Netto S, Generoso JS, Ceretta RA, Valim RF, Dominguini D, et al. Imipramine treatment reverses depressive- and anxiety-like behaviors, normalize adrenocorticotropic hormone, and reduces interleukin-1β in the brain of rats subjected to experimental periapical lesion. Pharmacol Rep. 2019;71(1):24–31. https://doi.org/10.1016/j.pharep.2018.08.003.

Article  CAS  PubMed  Google Scholar 

Bain JL, Lester SR, Henry WD, Pongetti JL, Blackman ME, Johnson RB. Association between maternal periapical lesions and brain inflammation in rat pups. Arch Oral Biol. 2013;58(3):266–71. https://doi.org/10.1016/j.archoralbio.2012.11.007.

Article  CAS  PubMed  Google Scholar 

Jespersen FVB, Hansen SU, Jensen SS, Omland LH, Helweg-Larsen J, Bjarnsholt T, et al. Cerebral abscesses with odontogenic origin: a population-based cohort study. Clin Oral Invest. 2023;27(7):3639–48. https://doi.org/10.1007/s00784-023-04976-6.

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