Cangrelor, a newer P2Y12 inhibitor, in neuro-interventional procedures: a systematic review and updated meta-analysis

Fugate SE, Cudd LA (2006) Cangrelor for treatment of coronary thrombosis. AnnPharmacother 40(5):925–930. https://doi.org/10.1345/aph.1g120

Article  CAS  Google Scholar 

Bhatt DL, Lincoff AM, Gibson CM, Stone GW, McNulty S, Montalescot G et al (2009) Intravenous platelet Blockade with Cangrelor during PCI. N Engl J Med 361(24):2330–2341. https://doi.org/10.1056/nejmoa0908629

Article  CAS  PubMed  Google Scholar 

Bhatt DL, Stone GW, Mahaffey KW, Gibson CM, Steg PG, Hamm CW et al (2013) Effect of platelet Inhibition with Cangrelor during PCI on ischemic events. N Engl J Med 368(14):1303–1313. https://doi.org/10.1056/nejmoa1300815

Article  CAS  PubMed  Google Scholar 

Harrington RA, Stone GW, McNulty S, White HD, Lincoff AM, Gibson CM et al (2009) Platelet Inhibition with Cangrelor in patients undergoing PCI. N Engl J Med 361(24):2318–2329. https://doi.org/10.1056/nejmoa0908628

Article  CAS  PubMed  Google Scholar 

Marnat G, Delvoye F, Finitsis S, Lapergue B, Gariel F, Consoli A et al (2021) A multicenter preliminary study of Cangrelor following thrombectomy failure for refractory proximal intracranial occlusions. AJNR Am J Neuroradiol 42(8):1452–1457. https://doi.org/10.3174/ajnr.a7180

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aguilar-Salinas P, Agnoletto GJ, Brasiliense LBC, Santos R, Granja MF, Gonsales D et al (2019) Safety and efficacy of Cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study. J Neurointerv Surg 11(4):347–351. https://doi.org/10.1136/neurintsurg-2018-014396

Article  PubMed  Google Scholar 

Majmundar M, Kansara T, Jain A, Shah P, Mithawala P, Desai R et al (2019) Meta-analysis of the role of Cangrelor for patients undergoing percutaneous coronary intervention. Am J Cardiol 123(7):1069–1075. https://doi.org/10.1016/j.amjcard.2018.12.039

Article  PubMed  Google Scholar 

Lawton JS, Tamis-Holland JE, Bangalore S, Bates ER, Beckie TM, Bischoff JM et al (2022) 2021 ACC/AHA/SCAI guideline for coronary artery revascularization. J Am Coll Cardiol 79(2):e21–129. https://doi.org/10.1016/j.jacc.2021.09.006

Article  PubMed  Google Scholar 

Marnat G, Finistis S, Delvoye F, Sibon I, Desilles J-P, Mazighi M et al (2022) Safety and efficacy of Cangrelor in acute stroke treated with mechanical thrombectomy: endovascular treatment of ischemic stroke registry and meta-analysis. AJNR Am J Neuroradiol 43(3):410–415. https://doi.org/10.3174/ajnr.a7430

Article  CAS  PubMed  PubMed Central  Google Scholar 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (eds) (2024) Cochrane Handbook for Systematic Reviews of Interventions version 6.5 (updated August 2024). Cochrane, Available from www.training.cochrane.org/handbook

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Sterne JA, Hernán MA, Reeves BC et al (2016) ROBINS-I: a tool for assessing risk of Bias in non-randomised studies of interventions. BMJ 355(355):i4919. https://doi.org/10.1136/bmj.i4919

Article  PubMed  PubMed Central  Google Scholar 

Abdennour L, Sourour N, Drir M, Premat K, Shotar E, Taylor G et al (2020) Preliminary experience with Cangrelor for endovascular treatment of challenging intracranial aneurysms. Clin Neuroradiol 30(3):453–461. https://doi.org/10.1007/s00062-019-00811-2

Article  PubMed  Google Scholar 

Cagnazzo F, Radu RA, Derraz I, Lefevre PH, Dargazanli C, Machi P et al (2023) Efficacy and safety of low dose intravenous Cangrelor in a consecutive cohort of patients undergoing neuroendovascular procedures. J Neurointerv Surg 16(1):88–93. https://doi.org/10.1136/jnis-2023-020094

Article  PubMed  Google Scholar 

Cervo A, Ferrari F, Barchetti G, Quilici L, Piano M, Boccardi E et al (2020) Use of Cangrelor in cervical and intracranial stenting for the treatment of acute ischemic stroke: A real life single-center experience. AJNR Am J Neuroradiol 41(11):2094–2099. https://doi.org/10.3174/ajnr.a6785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cortez GM, André J, Monteiro N, Sourour et al (2020) The use of Cangrelor in neurovascular interventions: a multicenter experience. Interventional Neuroradiol 63(6):925–934. https://doi.org/10.1007/s00234-020-02599-2

Article  Google Scholar 

Desai H, Al-Salihi MM, Morsi RZ et al (2023) Intravenous Cangrelor use for neuroendovascular procedures: a two-center experience and updated systematic review. Front Neurol 14. https://doi.org/10.3389/fneur.2023.1304599

Devarajan A, Gottiparthi S, Caton MT, Ouf A, Wu K, Goldman D et al (2024) The Safety and Efficacy of Cangrelor in Endovascular Thrombectomy Compared with Glycoprotein IIb/IIIa Inhibitors. medRxiv

El Aouni MC, Magro E, Abdelrady M, Nonent M, Gentric JC, Julien Ognard (2022) Safety and efficacy of Cangrelor among three antiplatelet regimens during Stent-Assisted endovascular treatment of unruptured intracranial aneurysm: A Single-Center retrospective study. Front Neurol 13. https://doi.org/10.3389/fneur.2022.727026

Elhorany M, Lenck S, Degos V, Sourour N-A, Frasca Polara G, Shotar E et al (2021) Cangrelor and stenting in acute ischemic stroke: monocentric case series: monocentric case series. Clin Neuroradiol 31(2):439–448. https://doi.org/10.1007/s00062-020-00907-0

Article  PubMed  Google Scholar 

Entezami P, Dalfino JC, Boulos AS et al (2022) Use of intravenous Cangrelor in the treatment of ruptured and unruptured cerebral aneurysms: an updated single-center analysis and pooled analysis of current studies. J NeuroInterventional Surg 15(7):669–673. https://doi.org/10.1136/neurintsurg-2022-018986

Article  Google Scholar 

Farooqui M, Divani AA, Galecio-Castillo M et al (2023) Safety outcomes of antiplatelet therapy during endovascular treatment of tandem lesions in acute ischemic stroke patients. Translational Stroke Res Published Online November 29. https://doi.org/10.1007/s12975-023-01214-9

Jumaa MA, Rodriguez-Calienes A, Dawod G, Vivanco-Suarez J, Hassan AE, Divani AA et al (2023) Low dose intravenous Cangrelor versus glycoprotein IIb/IIIa inhibitors in endovascular treatment of tandem lesions. J Stroke Cerebrovasc Dis 32(12):107438. https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107438

Article  PubMed  PubMed Central  Google Scholar 

Linfante I, Ravipati K, Starosciak AK, Reyes D, Dabus G (2021) Intravenous Cangrelor and oral Ticagrelor as an alternative to clopidogrel in acute intervention. J Neurointerv Surg 13(1):30–32. https://doi.org/10.1136/neurintsurg-2020-015841

Article  PubMed  Google Scholar 

Salahuddin H, Dawod G, Zaidi SF, Shawver J, Burgess R, Jumaa MA (2021) Safety of low dose intravenous Cangrelor in acute ischemic stroke: A case series. Front Neurol 12. https://doi.org/10.3389/fneur.2021.636682

Pop R, Finitsis SN, Marnat G et al (2024) Cangrelor for emergent carotid stenting during stroke thrombectomy: a comparative analysis versus glycoprotein IIb/IIIa inhibitors or aspirin monotherapy. J Neurointerv Surg Published Online September 6. https://doi.org/10.1136/jnis-2024-022125

Leonardi S, Bhatt DL (2019) Practical considerations for Cangrelor use in patients with acute coronary syndromes. Eur Heart J Acute Cardiovasc Care 8(1):39–44. https://doi.org/10.1177/2048872617707960

Article  PubMed  Google Scholar 

Qamar A, Bhatt DL (2016) Current status of data on Cangrelor. Pharmacol Ther 159:102–109. https://doi.org/10.1016/j.pharmthera.2016.01.004

Article  CAS  PubMed  Google Scholar 

Zhao W, Che R, Shang S, Wu C, Li C, Wu L et al (2017) Low-dose Tirofiban improves functional outcome in acute ischemic stroke patients treated with endovascular thrombectomy. Stroke 48(12):3289–3294. https://doi.org/10.1161/strokeaha.117.019193

Article  CAS  PubMed  Google Scholar 

Douketis JD, Spyropoulos AC, Kaatz S, Becker RC, Caprini JA, Dunn AS et al (2015) Perioperative bridging anticoagulation in patients with atrial fibrillation. N Engl J Med 373(9):823–833. https://doi.org/10.1056/NEJMoa1501035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif