Hofmarcher T, Manzano García A, Wilking N & Lindgren P. The Disease Burden and Economic Burden of Cancer in 9 Countries in the Middle East and Africa. Value Health Reg. 2023;37:81–87.
Ferlay J, et al. Cancer statistics for the year 2020: An overview. Int J Cancer. 2021. https://doi.org/10.1002/ijc.33588.
Stefan DC, Tang S. Addressing cancer care in low- to middle-income countries: a call for sustainable innovations and impactful research. BMC Cancer. 2023;23:756.
Article PubMed PubMed Central Google Scholar
Sung H, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71:209–49.
Parkin DM, et al. Changes in the Incidence of Cancer in Bulawayo, Zimbabwe over a 50-Year Period. Cancer Epidemiol Biomarkers Prev. 2021;30:867–73.
Hunger, S. P., Teachey, D. T., Grupp, S. & Aplenc, R. 93 - Childhood Leukemia. in Abeloff’s Clinical Oncology (Sixth Edition) (eds. Niederhuber, J. E., Armitage, J. O., Kastan, M. B., Doroshow, J. H. & Tepper, J. E.) 1748–1764.e4 (Elsevier, Philadelphia, 2020). https://doi.org/10.1016/B978-0-323-47674-4.00093-1.
Liu Y, et al. Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment. MedComm. 2021;2:315–40.
Article CAS PubMed PubMed Central Google Scholar
Anand U, et al. Cancer chemotherapy and beyond: Current status, drug candidates, associated risks and progress in targeted therapeutics. Genes Dis. 2022;10:1367–401.
Article PubMed PubMed Central Google Scholar
Wieland LS, et al. Risks and benefits of antioxidant dietary supplement use during cancer treatment: protocol for a scoping review. BMJ Open. 2021;11:e047200.
Article PubMed PubMed Central Google Scholar
Debela DT, et al. New approaches and procedures for cancer treatment: Current perspectives. SAGE Open Med. 2021;9:20503121211034370.
Article PubMed PubMed Central Google Scholar
WHO. African Traditional Medicine Day 2022. WHO | Regional Office for Africa https://www.afro.who.int/regional-director/speeches-messages/african-traditional-medicine-day-2022 (2022).
Iqbal J, et al. Plant-derived anticancer agents: A green anticancer approach. Asian Pac J Trop Biomed. 2017;7:1129–50.
Esmeeta A, et al. Plant-derived bioactive compounds in colon cancer treatment: An updated review. Biomed Pharmacother. 2022;153:113384.
Article CAS PubMed Google Scholar
Mlilo S, Sibanda S. An ethnobotanical survey of the medicinal plants used in the treatment of cancer in some parts of Matebeleland. Zimbabwe South Afr J Bot. 2022;146:401–8.
Ray A, Dittel B. Isolation of Mouse Peritoneal Cavity Cells. J Vis Exp JoVE. 2010;35:1488.
Mapfunde S, Sithole S, Mukanganyama S. In vitro toxicity determination of antifungal constituents from Combretum zeyheri. BMC Complement Altern Med. 2016;16:162.
Article PubMed PubMed Central Google Scholar
Machingauta A. et al. Evaluation of the antiproliferative effect of β-sitosterol isolated from Combretum platypetalum Welw. ex M.A. Lawson (Combretaceae) on Jurkat-T cells and protection by glutathione. Adv Tradit Med. 2022;22:865–873.
Skehan P, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst. 1990;82:1107–12.
Article CAS PubMed Google Scholar
McGaw, L. J., Elgorashi, E. E. & Eloff, J. N. 8 - Cytotoxicity of African Medicinal Plants Against Normal Animal and Human Cells. in Toxicological Survey of African Medicinal Plants (ed. Kuete, V.) 181–233 (Elsevier, 2014). https://doi.org/10.1016/B978-0-12-800018-2.00008-X.
Ogbole OO, Segun PA, Adeniji AJ. In vitro cytotoxic activity of medicinal plants from Nigeria ethnomedicine on Rhabdomyosarcoma cancer cell line and HPLC analysis of active extracts. BMC Complement Altern Med. 2017;17:494.
Article PubMed PubMed Central Google Scholar
Guevara BQ. UST Research Center for the Natural Sciences. A Guidebook to Plant Screening: Phytochemical and Biological. (University of Santo Tomas Publishing House, Manila, 2005:101–30.
Harborne AJ. Phytochemical Methods A Guide to Modern Techniques of Plant Analysis. (Springer Science & Business Media). 1998. p. 1–32.
Kumar A, Kaur S, Sangwan PL, Tasduq SA. Therapeutic and cosmeceutical role of glycosylated natural products in dermatology. Phytother Res. 2023;37:1574–89.
Article CAS PubMed Google Scholar
Avner BS, Fialho AM, Chakrabarty AM. Overcoming drug resistance in multi-drug resistant cancers and microorganisms: A conceptual framework. Bioengineered. 2012;3:262–70.
Article PubMed PubMed Central Google Scholar
Talib WH, Alsayed AR, Barakat M, Abu-Taha MI, Mahmod AI. Targeting Drug Chemo-Resistance in Cancer Using Natural Products. Biomedicines. 2021;9:1353.
Article CAS PubMed PubMed Central Google Scholar
Feola S, Russo S, Ylösmäki E, Cerullo V. Oncolytic ImmunoViroTherapy: A long history of crosstalk between viruses and immune system for cancer treatment. Pharmacol Ther. 2022;236:108103.
Article CAS PubMed Google Scholar
Huang M, Lu J-J, Ding J. Natural Products in Cancer Therapy: Past. Present and Future Nat Prod Bioprospecting. 2021;11:5–13.
Shaik BB, Katari NK, Jonnalagadda SB. Role of Natural Products in Developing Novel Anticancer Agents: A Perspective. Chem Biodivers. 2022;19:e202200535.
Article CAS PubMed Google Scholar
Elsyana V, Bintang M & Priosoeryanto BP. Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra (L.) Miq.) Leaves Extracts. Adv Pharmacol Pharm. Sci. 2016;2016:e3242698.
Ochocka JR, & Piotrowski A. Biologically active compounds from European mistletoe (Viscum album L.)1. Can J Plant Pathol. 2002;24:21–28.
Szurpnicka A, Kowalczuk A, Szterk A. Biological activity of mistletoe: in vitro and in vivo studies and mechanisms of action. Arch Pharm Res. 2020;43:593–629.
Article CAS PubMed PubMed Central Google Scholar
Hong J, et al. Novel drug isolated from mistletoe (1E,4E)-1,7-bis(4-hydroxyphenyl)hepta-1,4-dien-3-one for potential treatment of various cancers: synthesis, pharmacokinetics and pharmacodynamics. RSC Adv. 2020;10:27794–804.
Article CAS PubMed PubMed Central Google Scholar
Park J-H, Hyun C-K, Shin H-K. Cytotoxic effects of the components in heat-treated mistletoe (Viscum album). Cancer Lett. 1999;139:207–13.
Article CAS PubMed Google Scholar
Melo MN, de O. et al. A Scoping Review of Genus Viscum: Biological and Chemical Aspects of Alcoholic Extracts. Plants. 2023;12;1811.
Song C, et al. Exploring the resources of the genus Viscum for potential therapeutic applications. J Ethnopharmacol. 2021;277:114233.
Article CAS PubMed Google Scholar
Slika H, et al. Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms. Biomed Pharmacother. 2022;146:112442.
Article CAS PubMed Google Scholar
Sæbø IP, Bjørås M, Franzyk H, Helgesen E, Booth JA. Optimization of the Hemolysis Assay for the Assessment of Cytotoxicity. Int J Mol Sci. 2023;24:2914.
Article PubMed PubMed Central Google Scholar
Kundishora A, Sithole S, Mukanganyama S. Determination of the Cytotoxic Effect of Different Leaf Extracts from Parinari curatellifolia (Chrysobalanaceae). J Toxicol. 2020;2020:e8831545.
Paarvanova B, Tacheva B, Savova G, Karabaliev M, Georgieva R. Hemolysis by Saponin Is Accelerated at Hypertonic Conditions. Molecules. 2023;28:7096.
Article CAS PubMed PubMed Central Google Scholar
Ziyyat A, et al. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol. 1997;58:45–54.
Article CAS PubMed Google Scholar
Freedman, J. C. & Sperelakis, N. 13 - Diffusion and Permeability. in Cell Physiology Source Book (Third Edition) (ed. Sperelakis, N.) 209–216 (Academic Press, San Diego, 2001). https://doi.org/10.1016/B978-012656976-6/50105-0.
Khursheed A, et al. Efficacy of Phytochemicals Derived from Roots of Rondeletia odorata as Antioxidant, Antiulcer, Diuretic, Skin Brightening and Hemolytic Agents—A Comprehensive Biochemical and In Silico Study. Molecules. 2022;27:4204.
Comments (0)