Siegel RL, Kratzer TB, Giaquinto AN, et al. Cancer statistics, 2025. CA: Cancer J Clin. 2025;75:1–45.
Lenis AT, Lec PM, Chamie K. Bladder Cancer JAMA. 2020;324:1980–91.
Smith AB, Deal AM, Woods ME, Wallen EM, Pruthi RS, Chen RC, et al. Bladder cancer treatment and survival: evaluating treatment and survival in the National cancer data base. BJU Int. 2014;114:719–26.
Stein JP, Lieskovsky G, Cote R, Groshen S, Feng A-C, Boyd S, et al. Radical cystectomy in the treatment of invasive bladder cancer: Long-Term results in 1,054 patients. J Clin Oncol. 2001;41:3772–81.
Holzbeierlein J, Bixler BR, Buckley DI, Chang SS, Holmes RS, James AC et al. Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer: AUA/ASCO/SUO GUIDELINE (2017; Amended 2020, 2024). J Urol. 2024;101097JU0000000000003981.
Bruins HM, Veskimae E, Hernandez V, Imamura M, Neuberger MM, Dahm P, et al. The impact of the extent of lymphadenectomy on oncologic outcomes in patients undergoing radical cystectomy for bladder cancer: A systematic review. Eur Urol. 2014;66:1065–77.
Grossman HB, Natale RB, Tangen CM, Speights VO, Vogelzang NJ, Trump DL, et al. Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer. N Engl J Med. 2003;349:859–66.
Article CAS PubMed Google Scholar
Yin M, Joshi M, Meijer RP, Glantz M, Holder S, Harvey HA, et al. Neoadjuvant chemotherapy for Muscle-Invasive bladder cancer: A systematic review and Two‐Step Meta‐Analysis. Oncol. 2016;21:708–15.
Necchi A, Anichini A, Raggi D, Briganti A, Massa S, Lucianò R et al. Pembrolizumab as Neoadjuvant Therapy Before Radical Cystectomy in Patients With Muscle-Invasive Urothelial Bladder Carcinoma (PURE-01): An Open-Label, Single-Arm, Phase II Study. J Clin Oncol. 2018;36:JCO.18.01148.
Shabsigh A, Korets R, Vora KC, Brooks CM, Cronin AM, Savage C, et al. Defining early morbidity of radical cystectomy for patients with bladder cancer using a standardized reporting methodology. Eur Urol. 2009;55:164–76.
Quek ML, Stein JP, Daneshmand S, Miranda G, Thangathurai D, Roffey P, et al. A critical analysis of perioperative mortality from radical cystectomy. J Urol. 2006;175:886–90.
Grobet-Jeandin E, Lenfant L, Mir C, Giannarini G, Alcaraz A, Albersen M, et al. A systematic review of oncological outcomes associated with bladder-sparing strategies in patients achieving complete clinical response to initial systemic treatment for localized Muscle-invasive bladder cancer. Eur Urol Oncol. 2023;6:251–62.
Winoker JS, Liaw CW, Galsky MD, Wiklund P, Mehrazin R. Clinical complete response after neoadjuvant chemotherapy for Muscle-invasive bladder cancer: A call for standardized assessments and definitions. Eur Urol Focus. 2020;6:627–9.
Kukreja JB, Porten S, Golla V, Ho PL, Noguera-Gonzalez G, Navai N, et al. Absence of tumor on repeat transurethral resection of bladder tumor does not predict final pathologic T0 stage in bladder cancer treated with radical cystectomy. Eur Urol Focus. 2018;4:720–4.
Becker REN, Meyer AR, Brant A, Reese AC, Biles MJ, Harris KT, et al. Clinical restaging and tumor sequencing are inaccurate indicators of response to neoadjuvant chemotherapy for Muscle-invasive bladder cancer. Eur Urol. 2021;79:364–71.
Article CAS PubMed Google Scholar
Zibelman M, Asghar AM, Parker DC, O’Neill J, Wei S, Greenberg RE, et al. Cystoscopy and systematic bladder tissue sampling in predicting pT0 bladder cancer: A prospective trial. J Urol. 2021;205:1605–11.
Article PubMed PubMed Central Google Scholar
Luo C, Huang B, Wu Y, Chen J, Chen L. Use of vesical Imaging-Reporting and data system (VI-RADS) for detecting the muscle invasion of bladder cancer: a diagnostic meta-analysis. Eur Radiol. 2020;30:4606–14.
Pecoraro M, Giudice FD, Magliocca F, Simone G, Flammia S, Leonardo C, et al. Vesical Imaging-Reporting and data system (VI-RADS) for assessment of response to systemic therapy for bladder cancer: preliminary report. Abdom Radiol. 2022;47:763–70.
Necchi A, Basile G, Gibb EA, Raggi D, Calareso G, de Padua TC, et al. Vesical Imaging-Reporting and data system use predicting the outcome of neoadjuvant pembrolizumab in muscle‐invasive bladder cancer. BJU Int. 2024;133:214–22.
Article CAS PubMed Google Scholar
Panebianco V, Briganti A, Boellaard TN, Catto J, Comperat E, Efstathiou J, et al. Clinical application of bladder MRI and the vesical Imaging-Reporting and data system. Nat Rev Urol. 2024;21:243–51.
Choi SJ, Park KJ, Heo C, Park BW, Kim M, Kim JK. Radiomics-based model for predicting pathological complete response to neoadjuvant chemotherapy in muscle-invasive bladder cancer. Clin Radiol. 2021;76:e62713–21.
Soubra A, Gencturk M, Froelich J, Balaji P, Gupta S, Jha G, et al. FDG-PET/CT for assessing the response to neoadjuvant chemotherapy in bladder cancer patients. Clin Genitourin Cancer. 2018;16:360–4.
Unterrainer LM, Lindner S, Eismann L, Casuscelli J, Gildehaus F-J, Bui VN, et al. Feasibility of [68Ga]Ga-FAPI-46 PET/CT for detection of nodal and hematogenous spread in high-grade urothelial carcinoma. Eur J Nucl Med Mol Imaging. 2022;49:3571–80.
Article CAS PubMed PubMed Central Google Scholar
Novruzov E, Dendl K, Ndlovu H, Choyke PL, Dabir M, Beu M, et al. Head-to-head Intra-individual comparison of [68Ga]-FAPI and [18F]-FDG PET/CT in patients with bladder cancer. Mol Imaging Biol. 2022;24:651–8.
Article CAS PubMed PubMed Central Google Scholar
Duan X, Xia L, Zhang Z, Ren Y, Pomper MG, Rowe SP, et al. First-in-Human study of the radioligand 68Ga-N188 targeting Nectin-4 for PET/CT imaging of advanced urothelial carcinoma. Clin Cancer Res. 2023;29:3395–407.
Article CAS PubMed Google Scholar
ClinicalTrials.gov [Internet]. Available from: https://clinicaltrials.gov/.
Raitanen M-P, Aine R, Rintala E, Kallio J, Rajala P, Juusela H, et al. Differences between local and review urinary cytology in diagnosis of bladder cancer. An interobserver multicenter analysis. Eur Urol. 2002;41:284–9.
Palou J, Brausi M, Catto JWF. Management of patients with normal cystoscopy but positive cytology or urine markers. Eur Urol Oncol. 2020;3:548–54.
Gopalakrishna A, Fantony JJ, Longo TA, Owusu R, Foo W-C, Dash R, et al. Anticipatory positive urine tests for bladder cancer. Ann Surg Oncol. 2017;24:1747–53.
Birkenkamp-Demtröder K, Nordentoft I, Christensen E, Høyer S, Reinert T, Vang S, et al. Genomic alterations in liquid biopsies from patients with bladder cancer. Eur Urol. 2016;70:75–82.
Christensen E, Birkenkamp-Demtröder K, Sethi H, Shchegrova S, Salari R, Nordentoft I, et al. Early detection of metastatic relapse and monitoring of therapeutic efficacy by Ultra-Deep sequencing of plasma Cell-Free DNA in patients with urothelial bladder carcinoma. J Clin Oncol. 2019;37:JCO1802052.
Birkenkamp-Demtröder K, Christensen E, Nordentoft I, Knudsen M, Taber A, Høyer S, et al. Monitoring treatment response and metastatic relapse in advanced bladder cancer by liquid biopsy analysis. Eur Urol. 2018;73:535–40.
Dudley JC, Schroers-Martin J, Lazzareschi DV, Shi WY, Chen SB, Esfahani MS, et al. Detection and surveillance of bladder cancer using urine tumor DNA. Cancer Discov. 2018;9:CD–18.
Christensen E, Nordentoft I, Birkenkamp-Demtroder K, Elbæk SK, Lindskrog SV, Taber A, et al. Cell-free urine and plasma DNA mutational analysis predicts neoadjuvant chemotherapy response and outcome in patients with muscle invasive bladder cancer. Clin Cancer Res. 2023;29:1582–91.
Article CAS PubMed PubMed Central Google Scholar
Satyal U, Valentine H, Liu D, Slifker M, Lallas CD, Trabulsi EJ, et al. Urine biopsy as dynamic biomarker to enhance clinical staging of bladder cancer in radical cystectomy candidates. JCO Precis Oncol. 2024;8:e2300362.
Powles T, Assaf ZJ, Degaonkar V, Grivas P, Hussain M, Oudard S, et al. Updated overall survival by Circulating tumor DNA status from the phase 3 IMvigor010 trial: adjuvant Atezolizumab versus observation in Muscle-invasive urothelial carcinoma. Eur Urol. 2024;85:114–22.
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