Mutsaers, H.A.M., Merrild, C., Nørregaard, R., and Plana-Ripoll, O., The impact of fibrotic diseases on global mortality from 1990 to 2019, J. Transl. Med., 2023, vol. 21, no. 1, p. 818.

Article  PubMed  PubMed Central  Google Scholar 

Kis, K., Liu, X., and Hagood, J.S., Myofibroblast differentiation and survival in fibrotic disease, Expert Rev. Mol. Med., 2011, vol. 13, p. e27.

Article  PubMed  PubMed Central  Google Scholar 

Dees, C., Chakraborty, D., and Distler, J.H.W., Cellular and molecular mechanisms in fibrosis, Exp. Dermatol., 2021, vol. 30, no. 1, pp. 121–131.

Article  CAS  PubMed  Google Scholar 

Györfi, A.H., Matei, A.-E., and Distler, J.H.W., Targeting TGF-β signaling for the treatment of fibrosis, Matrix Biol., 2018, vols. 68–69, pp. 8–27.

Article  PubMed  Google Scholar 

Gabbiani, G., Ryan, G.B., and Majno, G., Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction, Experientia, 1971, vol. 27, no. 5, pp. 549–550.

Article  CAS  PubMed  Google Scholar 

Hinz, B., Phan, S.H., Thannickal, V.J., Prunotto, M., Desmoulière, A., Varga, J., De Wever, O., Mareel, M., and Gabbiani, G., Recent developments in myofibroblast biology, Am. J. Pathol., 2012, vol. 180, no. 4, pp. 1340–1355.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caplan, A.I., MSCs: The sentinel and safe-guards of injury, J. Cell. Physiol., 2016, vol. 231, no. 7, pp. 1413–1416.

Article  CAS  PubMed  Google Scholar 

Tai, Y., Woods, E.L., Dally, J., Kong, D., Steadman, R., Moseley, R., and Midgley, A.C., Myofibroblasts: Function, formation, and scope of molecular therapies for skin fibrosis, Biomolecules, 2021, vol. 11, no. 8, p. 1095.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalinina, N.I., Sysoeva, V.Y., Rubina, K.A., Parfenova, Y.V., and Tkachuk, V.A., Mesenchymal stem cells in tissue growth and repair, Acta Nat., 2011, vol. 3, no. 4, pp. 30–37.

Article  CAS  Google Scholar 

Orbay, H., Tobita, M., and Mizuno, H., Mesenchymal stem cells isolated from adipose and other tissues: Basic biological properties and clinical applications, Stem Cells Int., 2012, vol. 2012, p. 461718.

Article  PubMed  PubMed Central  Google Scholar 

Kalinina, N., Kharlampieva, D., Loguinova, M., Butenko, I., Pobeguts, O., Efimenko, A., Ageeva, L., Sharonov, G., Ischenko, D., Alekseev, D., Grigorieva, O., Sysoeva, V., Rubina, K., Lazarev, V., and Govorun, V., Characterization of secretomes provides evidence for adipose-derived mesenchymal stromal cells subtypes, Stem Cell Res. Ther., 2015, vol. 6, no. 1, p. 221.

Article  PubMed  PubMed Central  Google Scholar 

Sagaradze, G.D., Basalova, N.A., Efimenko, A.Yu., and Tkachuk, V.A., Mesenchymal stromal cells as critical contributors to tissue regeneration, Front. Cell Dev. Biol., 2020, vol. 8, p. 576176.

Article  PubMed  PubMed Central  Google Scholar 

Qiu, G., Zheng, G., Ge, M., Wang, J., Huang, R., Shu, Q., and Xu, J., Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs, Stem Cell Res. Ther., 2018, vol. 9, no. 1, p. 320.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sisa, C., Kholia, S., Naylor, J., Herrera Sanchez, M.B., Bruno, S., Deregibus, M.C., Camussi, G., Inal, J.M., Lange, S., and Hristova, M., Mesenchymal stromal cell derived extracellular vesicles reduce hypoxia-ischaemia induced perinatal brain injury, Front. Physiol., 2019, vol. 10, p. 282.

Article  PubMed  PubMed Central  Google Scholar 

Casado-Díaz, A., Quesada-Gómez, J.M., Dorado, G., Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: Applications in skin wound healing, Front. Bioeng. Biotechnol., 2020, vol. 8, p. 146.

Article  PubMed  PubMed Central  Google Scholar 

Basalova, N., Sagaradze, G., Arbatskiy, M., Evtushenko, E., Kulebyakin, K., Grigorieva, O., Akopyan, Z., Kalinina, N., and Efimenko, A., Secretome of mesenchymal stromal cells prevents myofibroblasts differentiation by transferring fibrosis-associated microRNAs within extracellular vesicles, Cells, 2020, vol. 9, no. 5, p. 1272.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulebyakina, M., Basalova, N., Butuzova, D., Arbatsky, M., Chechekhin, V., Kalinina, N., Tyurin-Kuzmin, P., Kulebyakin, K., Klychnikov, O., and Efimenko, A., Balance between pro- and antifibrotic proteins in mesenchymal stromal cell secretome fractions revealed by proteome and cell subpopulation analysis, Int. J. Mol. Sci., 2023, vol. 25, no. 1, p. 290.

Article  PubMed  PubMed Central  Google Scholar 

Ye, J., Coulouris, G., Zaretskaya, I., Cutcutache, I., Rozen, S., and Madden, T.L., Primer-BLAST: A tool to design target-specific primers for polymerase chain reaction, BMC Bioinf., 2012, vol. 13, no. 1, p. 134.

Article  CAS  Google Scholar 

Tian, B., Li, X., Kalita, M., Widen, S.G., Yang, J., Bhavnani, S.K., Dang, B., Kudlicki, A., Sinha, M., Kong, F., Wood, T.G., Luxon, B.A., and Brasier, A.R., Analysis of the TGFβ-induced program in primary airway epithelial cells shows essential role of NF-κB/RelA signaling network in type II epithelial mesenchymal transition, BMC Genomics, 2015, vol. 16, no. 1, p. 529.

Article  PubMed  PubMed Central  Google Scholar 

Bukong, T.N., Maurice, S.B., Chahal, B., Schaeffer, D.F., and Winwood, P.J., Versican: A novel modulator of hepatic fibrosis, Lab. Invest., 2016, vol. 96, no. 3, pp. 361–374.

Article  CAS  PubMed  Google Scholar 

Baarsma, H.A., Spanjer, A.I.R., Haitsma, G., Engelbertink, L.H.J.M., Meurs, H., Jonker, M.R., Timens, W., Postma, D.S., Kerstjens, H.A.M., and Gosens, R., Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β1 is increased in chronic obstructive pulmonary disease, PLoS One, 2011, vol. 6, no. 9, p. e25450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Königshoff, M., Balsara, N., Pfaff, E.-M., Kramer, M., Chrobak, I., Seeger, W., and Eickelberg, O., Functional Wnt signaling is increased in idiopathic pulmonary fibrosis, PLoS One, 2008, vol. 3, no. 5, p. e2142.

Article  PubMed  PubMed Central  Google Scholar 

Sobel, K., Tham, M., Stark, H., Stammer, H., Prätzel-Wunder, S., Bickenbach, J.R., and Boukamp, P., Wnt-3a-activated human fibroblasts promote human keratinocyte proliferation and matrix destruction, Int. J. Cancer, 2015, vol. 136, no. 12, pp. 2786–2798.

Article  CAS  PubMed  Google Scholar 

Syed, F. and Bayat, A., Notch signaling pathway in keloid disease: Enhanced fibroblast activity in a Jagged-1 peptide-dependent manner in lesional vs. extralesional fibroblasts, Wound Repair Regener., 2012, vol. 20, no. 5, pp. 688–706.

Article  Google Scholar 

Pupo, M., Pisano, A., Abonante, S., Maggiolini, M., and Musti, A.M., GPER activates Notch signaling in breast cancer cells and cancer-associated fibroblasts (CAFs), Int. J. Biochem. Cell Biol., 2014, vol. 46, p. 56–67.

Article  CAS  PubMed  Google Scholar 

Longobardi, E. and Blasi, F., Overexpression of PREP‑1 in F9 teratocarcinoma cells leads to a functionally relevant increase of PBX-2 by preventing its degradation, J. Biol. Chem., 2003, vol. 278, no. 40, pp. 39235–39241.

Article  CAS  PubMed  Google Scholar 

Laemmli, U.K., Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 1970, vol. 227, no. 5259, pp. 680–685.

Article  CAS  PubMed  Google Scholar 

Towbin, H., Staehelin, T., and Gordon, J., Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications, Proc. Natl. Acad. Sci. U. S. A., 1979, vol. 76, no. 9, pp. 4350–4354.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spanjer, A.I., Baarsma, H.A., Oostenbrink, L.M., Jansen, S.R., Kuipers, C.C., Lindner, M., Postma, D.S., Meurs, H., Heijink, I.H., Gosens, R., and Königshoff, M., TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8, FASEB J., 2016, vol. 30, no. 5, pp. 1823–1835.

Article  CAS  PubMed  Google Scholar 

Klein, E.A. and Assoian, R.K., Transcriptional regulation of the cyclin D1 gene at a glance, J. Cell Sci., 2008, vol. 121, no. 23, pp. 3853–3857.