Jia G, Fu Y, He C. Reversible RNA adenosine methylation in biological regulation. Trends Genet. 2013;29(2):108–15.
Yue Y, Liu J, He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015;29(13):1343–55.
CAS PubMed PubMed Central Google Scholar
Gilbert WV, Bell TA, Schaening C, Messenger. RNA modifications: form, distribution, and function. Science. 2016;352(6292):1408–12.
CAS PubMed PubMed Central Google Scholar
Roignant JY, Soller M. m(6)A in mRNA: an ancient mechanism for Fine-Tuning gene expression. Trends Genet. 2017;33(6):380–90.
Zaccara S, Ries RJ, Jaffrey SR. Reading, writing and erasing mRNA methylation. Nat Rev Mol Cell Biol. 2019;20(10):608–24.
He L, Li H, Wu A, Peng Y, Shu G, Yin G. Functions of N6-methyladenosine and its role in cancer. Mol Cancer. 2019;18(1):176.
PubMed PubMed Central Google Scholar
Feng H, Yuan X, Wu S, Yuan Y, Cui L, Lin D, et al. Effects of writers, erasers and readers within miRNA-related m6A modification in cancers. Cell Prolif. 2023;56(1):e13340.
Chen XY, Zhang J, Zhu JS. The role of m(6)A RNA methylation in human cancer. Mol Cancer. 2019;18(1):103.
PubMed PubMed Central Google Scholar
Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, et al. A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol. 2014;10(2):93–5.
Wang Y, Li Y, Toth JI, Petroski MD, Zhang Z, Zhao JC. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat Cell Biol. 2014;16(2):191–8.
CAS PubMed PubMed Central Google Scholar
Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, et al. m(6)A RNA methylation regulates the Self-Renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 2017;18(11):2622–34.
CAS PubMed PubMed Central Google Scholar
Li P, Richard HT, Zhu K, Li L, Huang S. The roles and regulation of m(6)A modification in glioblastoma stem cells and tumorigenesis. Biomedicines. 2022; 10(5).
Shi K, Sa R, Dou L, Wu Y, Dong Z, Fu X, et al. Correction: METTL3 exerts synergistic effects on m6A methylation and histone modification to regulate the function of VGF in lung adenocarcinoma. Clin Epigenetics. 2024;16(1):2.
PubMed PubMed Central Google Scholar
Chen M, Wei L, Law CT, Tsang FH, Shen J, Cheng CL, et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional Silencing of SOCS2. Hepatology. 2018;67(6):2254–70.
Pan F, Lin XR, Hao LP, Chu XY, Wan HJ, Wang R. The role of RNA methyltransferase METTL3 in hepatocellular carcinoma: results and perspectives. Front Cell Dev Biol. 2021;9:674919.
PubMed PubMed Central Google Scholar
Ferro A, Peleteiro B, Malvezzi M, Bosetti C, Bertuccio P, Levi F, et al. Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype. Eur J Cancer. 2014;50(7):1330–44.
Figueiredo C, Camargo MC, Leite M, Fuentes-Pananá EM, Rabkin CS, Machado JC. Pathogenesis of gastric cancer: genetics and molecular classification. Curr Top Microbiol Immunol. 2017;400:277–304.
CAS PubMed PubMed Central Google Scholar
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485(7397):201–6.
Zhou Y, Huang T, Siu HL, Wong CC, Dong Y, Wu F, et al. IGF2BP3 functions as a potential oncogene and is a crucial target of miR-34a in gastric carcinogenesis. Mol Cancer. 2017;16(1):77.
PubMed PubMed Central Google Scholar
Zhu W, Wang JZ, Xu Z, Cao M, Hu Q, Pan C, et al. Detection of N6–methyladenosine modification residues (Review). Int J Mol Med. 2019;43(6):2267–78.
CAS PubMed PubMed Central Google Scholar
Zhao BS, Wang X, Beadell AV, Lu Z, Shi H, Kuuspalu A, et al. m(6)A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transition. Nature. 2017;542(7642):475–8.
CAS PubMed PubMed Central Google Scholar
Patil DP, Pickering BF, Jaffrey SR. Reading m(6)A in the transcriptome: m(6)A-Binding proteins. Trends Cell Biol. 2018;28(2):113–27.
Lan Q, Liu PY, Haase J, Bell JL, Hüttelmaier S, Liu T. The critical role of RNA m(6)A methylation in cancer. Cancer Res. 2019;79(7):1285–92.
Sun T, Wu R, Ming L. The role of m6A RNA methylation in cancer. Biomed Pharmacother. 2019;112:108613.
Du J, Hou K, Mi S, Ji H, Ma S, Ba Y, et al. Malignant evaluation and clinical prognostic values of m6A RNA methylation regulators in glioblastoma. Front Oncol. 2020;10:208.
PubMed PubMed Central Google Scholar
Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014;15(6):707–19.
CAS PubMed PubMed Central Google Scholar
Li Y, Wang X, Li C, Hu S, Yu J, Song S. Transcriptome-wide N⁶-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification. RNA Biol. 2014;11(9):1180–8.
PubMed PubMed Central Google Scholar
Sang L, Sun L, Wang A, Zhang H, Yuan Y. The N6-Methyladenosine features of mRNA and aberrant expression of m6A modified genes in gastric cancer and their potential impact on the risk and prognosis. Front Genet. 2020;11:561566.
CAS PubMed PubMed Central Google Scholar
Zhang C, Zhang M, Ge S, Huang W, Lin X, Gao J, et al. Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. Cancer Med. 2019;8(10):4766–81.
CAS PubMed PubMed Central Google Scholar
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74.
Zhang T, Gong Y, Meng H, Li C, Xue L. Symphony of epigenetic and metabolic regulation-interaction between the histone methyltransferase EZH2 and metabolism of tumor. Clin Epigenetics. 2020;12(1):72.
CAS PubMed PubMed Central Google Scholar
Wang Q, Guo X, Li L, Gao Z, Su X, Ji M, et al. N(6)-methyladenosine METTL3 promotes cervical cancer tumorigenesis and Warburg effect through YTHDF1/HK2 modification. Cell Death Dis. 2020;11(10):911.
CAS PubMed PubMed Central Google Scholar
Liu X, Feng M, Hao X, Gao Z, Wu Z, Wang Y, et al. m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop. Oncogene. 2023;42(25):2047–60.
CAS PubMed PubMed Central Google Scholar
Kahl M, Xu Z, Arumugam S, Edens B, Fischietti M, Zhu AC, et al. m6A RNA methylation regulates mitochondrial function. Hum Mol Genet. 2024;33(11):969–80.
CAS PubMed PubMed Central Google Scholar
Wang S, Zhang W, Wang Z, Liu Z, Yi X, Wu J. Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease. Cell Signal. 2024;121:111303.
Hirayama A, Kami K, Sugimoto M, Sugawara M, Toki N, Onozuka H, et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res. 2009;69(11):4918–25.
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