Dubey JP. Toxoplasmosis of animals and humans. 3rd ed. Boca Raton: CRC Press; 2022.
Milne G, Webster JP, Walker M. Toxoplasma gondii: an underestimated threat? Trends Parasitol. 2020;36(12):959–69.
Elsheikha HM, Marra CM, Zhu XQ. Epidemiology, pathophysiology, diagnosis, and management of cerebral toxoplasmosis. Clin Microbiol Rev. 2021;34(1):e00115-e119.
Matta SK, Rinkenberger N, Dunay IR, Sibley LD. Toxoplasma gondii infection and its implications within the central nervous system. Nat Rev Microbiol. 2021;19(7):467–80.
Sibley LD, Ajioka JW. Population structure of Toxoplasma gondii: clonal expansion driven by infrequent recombination and selective sweeps. Annu Rev Microbiol. 2008;62:329–51.
Hunter CA, Sibley LD. Modulation of innate immunity by Toxoplasma gondii virulence effectors. Nat Rev Microbiol. 2012;10(11):766–78.
CAS PubMed PubMed Central Google Scholar
Sibley LD, Boothroyd JC. Virulent strains of Toxoplasma gondii comprise a single clonal lineage. Nature. 1992;359(6390):82–5.
du Plooy I, Mlangeni M, Christian R, Tsotetsi-Khambule AM. An African perspective on the genetic diversity of Toxoplasma gondii: a systematic review. Parasitology. 2023;150(7):551–78.
PubMed PubMed Central Google Scholar
Chaichan P, Mercier A, Galal L, Mahittikorn A, Ariey F, Morand S, et al. Geographical distribution of Toxoplasma gondii genotypes in Asia: a link with neighboring continents. Infect Genet Evol. 2017;53:227–38.
Behnke MS, Dubey JP, Sibley LD. Genetic mapping of pathogenesis determinants in Toxoplasma gondii. Annu Rev Microbiol. 2016;70:63–81.
Guo G, Lin Y, Zhu X, Ding F, Xue X, Zhang Q. Emerging roles of the epitranscriptome in parasitic protozoan biology and pathogenesis. Trends Parasitol. 2024;40(3):214–29.
Zhao BS, Roundtree IA, He C. Post-transcriptional gene regulation by mRNA modifications. Nat Rev Mol Cell Biol. 2017;18(1):31–42.
Baumgarten S, Bryant JM, Sinha A, Reyser T, Preiser PR, Dedon PC, et al. Transcriptome-wide dynamics of extensive m(6)A mRNA methylation during Plasmodium falciparum blood-stage development. Nat Microbiol. 2019;4(12):2246–59.
PubMed PubMed Central Google Scholar
Chen YS, Yang WL, Zhao YL, Yang YG. Dynamic transcriptomic m(5)c and its regulatory role in RNA processing. WIREs RNA. 2021;12(4):e1639.
Chen D, Gu X, Nurzat Y, Xu L, Li X, Wu L, et al. Writers, readers, and erasers RNA modifications and drug resistance in cancer. Mol Cancer. 2024;23(1):178.
CAS PubMed PubMed Central Google Scholar
Alarcon CR, Goodarzi H, Lee H, Liu X, Tavazoie S, Tavazoie SF. HNRNPA2B1 is a mediator of m(6)a-dependent nuclear RNA processing events. Cell. 2015;162(6):1299–308.
CAS PubMed PubMed Central Google Scholar
Wang W, Yang Y, Guo H, Li MH, Chen XQ, Wei XY, et al. Unravelling strain-specific modifications of Toxoplasma gondii tRNA and sncRNA using LC-MS/MS. Microbiol Spectr. 2023;11(3):e0356422.
Han X, Wang M, Zhao YL, Yang Y, Yang YG. RNA methylations in human cancers. Semin Cancer Biol. 2021;75:97–115.
Liu L, Chen Y, Zhang T, Cui G, Wang W, Zhang G, et al. YBX1 promotes esophageal squamous cell carcinoma progression via m5C-dependent SMOX mRNA stabilization. Adv Sci. 2024;11(20):e2302379.
Wang Y, Wei J, Feng L, Li O, Huang L, Zhou S, et al. Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer. Mol Cancer. 2023;22(1):81.
CAS PubMed PubMed Central Google Scholar
Chen Y, Jiang Z, Zhang C, Zhang L, Chen H, Xiao N, et al. 5-methylcytosine transferase NSUN2 drives NRF2-mediated ferroptosis resistance in non-small cell lung cancer. J Biol Chem. 2024;300(4):106793.
CAS PubMed PubMed Central Google Scholar
Qi Q, Zhong R, Huang Y, Tang Y, Zhang XW, Liu C, Gao CF, et al. The RNA M5C methyltransferase NSUN2 promotes progression of hepatocellular carcinoma by enhancing PKM2-mediated glycolysis. Cell Death Dis. 2025;16(1):82.
CAS PubMed PubMed Central Google Scholar
Yu T, Zhang Q, Yu SK, Nie FQ, Zhang ML, Wang Q, et al. THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification. Cell Death Dis. 2023;14(7):475.
CAS PubMed PubMed Central Google Scholar
Li Q, Guo G, Chen Y, Lu L, Li H, Zhou Z, et al. HCP5 derived novel microprotein triggers progression of gastric cancer through regulating ferroptosis. Adv Sci. 2024;11(46):e2407012.
Jian D, Cheng X, Qi D, Wang S, Wang C, Shi Y, et al. Nsun2 controls cardiac homeostasis and hypertrophic response by regulating PRKACA expression. Theranostics. 2025;15(6):2393–412.
CAS PubMed PubMed Central Google Scholar
Selmi T, Hussain S, Dietmann S, Heiss M, Borland K, Flad S, et al. Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6. Nucleic Acids Res. 2021;49(2):1006–22.
Zhang X, Zhang Y, Li R, Li Y, Wang Q, Wang Y, et al. STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m(5)c methylation of Gpx4 mRNA. Cell Rep. 2024;43(11):114885.
Sajini AA, Choudhury NR, Wagner RE, Bornelov S, Selmi T, Spanos C, et al. Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. Nat Commun. 2019;10(1):2550.
PubMed PubMed Central Google Scholar
Chen X, Li A, Sun BF, Yang Y, Han YN, Yuan X, et al. 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mrnas. Nat Cell Biol. 2019;21(8):978–90.
Goodarzi H, Liu X, Nguyen HC, Zhang S, Fish L, Tavazoie SF. Endogenous tRNA-derived fragments suppress breast cancer progression via YBX1 displacement. Cell. 2015;161(4):790–802.
CAS PubMed PubMed Central Google Scholar
Kong W, Biswas A, Zhou D, Fiches G, Fujinaga K, Santoso N, et al. Nucleolar protein NOP2/NSUN1 suppresses HIV-1 transcription and promotes viral latency by competing with Tat for TAR binding and methylation. PLoS Pathog. 2020;16(3):e1008430.
CAS PubMed PubMed Central Google Scholar
Liu M, Guo G, Qian P, Mu J, Lu B, He X, et al. 5-methylcytosine modification by Plasmodium NSUN2 stabilizes mRNA and mediates the development of gametocytes. Proc Natl Acad Sci USA. 2022;119(9):e2110713119.
CAS PubMed PubMed Central Google Scholar
Hammam E, Sinha A, Baumgarten S, Nardella F, Liang J, Miled S, et al. Malaria parasite stress tolerance is regulated by DNMT2-mediated tRNA cytosine methylation. MBio. 2021;12(6):e0255821.
Shen B, Brown KM, Lee TD, Sibley LD. Efficient gene disruption in diverse strains of Toxoplasma gondii using CRISPR/CAS9. MBio. 2014;5(3):e01114-e1214.
PubMed PubMed Central Google Scholar
Wang JL, Li TT, Zhang NZ, Wang M, Sun LX, Zhang ZW, et al. The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony. Nat Commun. 2024;15(1):793.
CAS PubMed PubMed Central Google Scholar
Zheng XN, Li TT, Elsheikha HM, Wang M, Sun LX, Wu XJ, et al. GRA47 is important for the morphology and permeability of the parasitophorous vacuole in Toxoplasma gondii. Int J Parasitol. 2024;54(11):583–96.
Wei C, Cao H, Li C, Song H, Liu Q, Zhu X, Zheng W. Differences in N6-methyladenosine (m6A) methylation among the three major clonal lineages of Toxoplasma gondii tachyzoites. JIA. 2024; Online ahead of pri
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