Dendritic spine degeneration is associated with age-related decline in recognition and spatial memory in male mice

Aguilar-Hernandez L, Vazquez-Hernandez AJ, de-Lima-Mar DF, Vazquez-Roque RA, Tendilla-Beltran H, Flores G (2020) Memory and dendritic spines loss, and dynamic dendritic spines changes are age-dependent in the rat. J Chem Neuroanat 110:101858

CAS  PubMed  Google Scholar 

Aguilar-Hernandez L, Alejandre R, Morales-Medina C, Iannitti JT, Flores G (2023) Cellular mechanisms in brain aging: focus on physiological and pathological aging. J Chem Neuroanat 128:102210

CAS  PubMed  Google Scholar 

Arias-Cavieres A, Adasme T, Sanchez G, Munoz P, Hidalgo C (2017) Aging impairs hippocampal- dependent recognition memory and LTP and prevents the associated RyR up-regulation. Front Aging Neurosci 9:111

PubMed  PubMed Central  Google Scholar 

Bartsch T, Wulff P (2015) The hippocampus in aging and disease: from plasticity to vulnerability. Neuroscience 309:1–16

CAS  PubMed  Google Scholar 

Becker LE, Armstrong DL, Chan F (1986) Dendritic atrophy in children with Down’s syndrome. Ann Neurol 20:520–526

CAS  PubMed  Google Scholar 

Bello-Medina PC, Flores G, Quirarte GL, McGaugh JL, Prado Alcala RA (2016) Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training. Proc Natl Acad Sci U S A 113:E6516–E6525

CAS  PubMed  PubMed Central  Google Scholar 

Benavides-Piccione R, Fernaud-Espinosa I, Robles V, Yuste R, DeFelipe J (2013) Age-based comparison of human dendritic spine structure using complete three-dimensional reconstructions. Cereb Cortex 23:1798–1810

PubMed  Google Scholar 

Bencsik N, Pusztai S, Borbely S, Fekete A, Dulk M, Kis V, Pesti S, Vas V, Szucs A, Buday L, Schlett K (2019) Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Sci Rep 9:16843

PubMed  PubMed Central  Google Scholar 

Benoit CE, Rowe WB, Menard C, Sarret P, Quirion R (2011) Genomic and proteomic strategies to identify novel targets potentially involved in learning and memory. Trends Pharmacol Sci 32:43–52

CAS  PubMed  Google Scholar 

Borgoni S, Kudryashova KS, Burka K, de Magalhaes JP (2021) Targeting immune dysfunction in aging. Ageing Res Rev 70:101410

CAS  PubMed  Google Scholar 

Braun AA, Amos-Kroohs RM, Gutierrez A, Lundgren KH, Seroogy KB, Vorhees CV, Williams MT (2016) 6-hydroxydopamine-induced dopamine reductions in the nucleus accumbens, but not the medial prefrontal cortex, impair Cincinnati water maze egocentric and Morris water maze allocentric navigation in male Sprague-Dawley rats. Neurotox Res 30:199–212

CAS  PubMed  Google Scholar 

Brown MA, Sharp PE (1995) Simulation of spatial learning in the Morris water maze by a neural network model of the hippocampal formation and nucleus accumbens. Hippocampus 5:171–188

CAS  PubMed  Google Scholar 

Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nat Rev Neurosci 7:30–40

CAS  PubMed  Google Scholar 

Calcinotto A, Kohli J, Zagato E, Pellegrini L, Demaria M, Alimonti A (2019) Cellular senescence: aging, cancer, and injury. Physiol Rev 99:1047–1078

CAS  PubMed  Google Scholar 

Caplan LJ, Lipman PD (1995) Age and gender differences in the effectiveness of map-like learning aids in memory for routes. J Gerontol B Psychol Sci Soc Sci 50:P126–133

CAS  PubMed  Google Scholar 

Cauli O, Llansola M, Rodrigo R, El Mlili N, Errami M, Felipo V (2005) Altered modulation of motor activity by group I metabotropic glutamate receptors in the nucleus accumbens in hyperammonemic rats. Metab Brain Dis 20:347–358

CAS  PubMed  Google Scholar 

Cerqueira JJ, Pego JM, Taipa R, Bessa JM, Almeida OF, Sousa N (2005) Morphological correlates of corticosteroid-induced changes in prefrontal cortex-dependent behaviors. J Neurosci 25:7792–7800

CAS  PubMed  PubMed Central  Google Scholar 

Chidambaram SB, Rathipriya AG, Bolla SR, Bhat A, Ray B, Mahalakshmi AM, Manivasagam T, Thenmozhi AJ, Essa MM, Guillemin GJ, Chandra R, Sakharkar MK (2019) Dendritic spines: revisiting the physiological role. Prog Neuropsychopharmacol Biol Psychiatry 92:161–193

CAS  PubMed  Google Scholar 

da Silva PFL, Schumacher B (2021) Principles of the molecular and cellular mechanisms of aging. J Invest Dermatol 141:951–960

PubMed  Google Scholar 

Dickstein DL, Kabaso D, Rocher AB, Luebke JI, Wearne SL, Hof PR (2007) Changes in the structural complexity of the aged brain. Aging Cell 6:275–284

CAS  PubMed  Google Scholar 

Dutta S, Sengupta P (2016) Men and mice: relating their ages. Life Sci 152:244–248

CAS  PubMed  Google Scholar 

Ennaceur A, Chazot PL (2016) Preclinical animal anxiety research - flaws and prejudices. Pharmacol Res Perspect 4:e00223

PubMed  PubMed Central  Google Scholar 

Espinoza I, Gomez-Villalobos MJ, Aguilar-Hernandez L, Flores G, Morales-Medina JC (2025) Cerebrolysin treatment improved short-term memory deficits while simultaneously increasing hippocampal spine density in hypertensive female rats. Behav Brain Res 481:115436

CAS  PubMed  Google Scholar 

Flores G, Alquicer G, Silva-Gomez AB, Zaldivar G, Stewart J, Quirion R, Srivastava LK (2005) Alterations in dendritic morphology of prefrontal cortical and nucleus accumbens neurons in post-pubertal rats after neonatal excitotoxic lesions of the ventral hippocampus. Neuroscience 133:463–470

CAS  PubMed  Google Scholar 

Flores G, Morales-Medina JC, Rodriguez-Sosa L, Calderon-Rosete G (2015) Characterization of cytoarchitecture of dendrites and fiber neurons using the golgi-cox method: an overview. Horizons in neuroscience research. Nova biomedica, New York, pp 137–146

Google Scholar 

Flores G, Flores-Gomez GD, Diaz A, Penagos-Corzo JC, Iannitti T, Morales-Medina JC (2020) Natural products present neurotrophic properties in neurons of the limbic system in aging rodents. Synapse 75:e22185

PubMed  Google Scholar 

Freire-Cobo C, Rothwell ES, Varghese M, Edwards M, Janssen WGM, Lacreuse A, Hof PR (2023) Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus). Neurobiol Aging 123:49–62

CAS  PubMed  Google Scholar 

Goldman-Rakic PS (1995) Architecture of the prefrontal cortex and the central executive. Ann N Y Acad Sci 769:71–83

CAS  PubMed  Google Scholar 

Gonzalez-Granillo AE, Gnecco D, Diaz A, Garces-Ramirez L, de la Cruz F, Juarez I, Morales-Medina JC, Flores G (2022) Curcumin induces cortico-hippocampal neuronal reshaping and memory improvements in aged mice. J Chem Neuroanat 121:102091

CAS  PubMed  Google Scholar 

Hajam YA, Rani R, Ganie SY, Sheikh TA, Javaid D, Qadri SS, Pramodh S, Alsulimani A, Alkhanani MF, Harakeh S, Hussain A, Haque S, Reshi MS (2022) Oxidative stress in human pathology and aging: molecular mechanisms and perspectives. Cells. https://doi.org/10.3390/cells11030552

PubMed  PubMed Central  Google Scholar 

Harris KM, Weinberg RJ (2012) Ultrastructure of synapses in the mammalian brain. Cold Spring Harb Perspect Biol. https://doi.org/10.1101/cshperspect.a005587

PubMed  PubMed Central  Google Scholar 

Hendrickx JO, De Moudt S, Calus E, De Deyn PP, Van Dam D, De Meyer GRY (2022) Age-related cognitive decline in Spatial learning and memory of C57BL/6J mice. Behav Brain Res 418:113649

PubMed  Google Scholar 

Hou Y, Dan X, Babbar M, Wei Y, Hasselbalch SG, Croteau DL, Bohr VA (2019) Ageing as a risk factor for neurodegenerative disease. Nat Rev Neurol 15:565–581

PubMed  Google Scholar 

Joyce MKP, Uchendu S, Arnsten AFT (2025) Stress and inflammation target dorsolateral prefrontal cortex function: neural mechanisms underlying weakened cognitive control. Biol Psychiatry 97:359–371

CAS  PubMed  Google Scholar 

Kesner RP (2000) Behavioral analysis of the contribution of the hippocampus and parietal cortex to the processing of information: interactions and dissociations. Hippocampus 10:483–490

CAS  PubMed  Google Scholar 

Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG (2010) Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 8:e1000412

PubMed  PubMed Central  Google Scholar 

Kolb B, Buhrmann K, McDonald R, Sutherland RJ (1994) Dissociation of the medial prefrontal, posterior parietal, and posterior temporal cortex for spatial navigation and recognition memory in the rat. Cereb Cortex 4:664–680

CAS  PubMed  Google Scholar 

Koleske AJ (2013) Molecular mechanisms of dendrite stability. Nat Rev Neurosci 14:536–550

CAS  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif