Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023;73(1):17–48.
Wang M, Herbst RS, Boshoff C. Toward personalized treatment approaches for non-small-cell lung cancer. Nat Med. 2021;27(8):1345–56.
Article CAS PubMed Google Scholar
Wood SL, Pernemalm M, Crosbie PA, Whetton AD. The role of the tumor-microenvironment in lung cancer-metastasis and its relationship to potential therapeutic targets. Cancer Treat Rev. 2014;40(4):558–66.
Article CAS PubMed Google Scholar
Chen R, Manochakian R, James L, Azzouqa A-G, Shi H, Zhang Y, et al. Emerging therapeutic agents for advanced non-small cell lung cancer. J Hematol Oncol. 2020;13(1):58.
Article PubMed PubMed Central Google Scholar
Simeone JC, Nordstrom BL, Patel K, Klein AB. Treatment patterns and overall survival in metastatic non-small-cell lung cancer in a real-world. US setting Future Oncol. 2019;15(30):3491–502.
Article CAS PubMed Google Scholar
de Visser KE, Joyce JA. The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth. Cancer Cell. 2023;41(3):374–403.
Wong KY, Cheung AH-K, Chen B, Chan WN, Yu J, Lo KW, et al. Cancer-associated fibroblasts in nonsmall cell lung cancer: from molecular mechanisms to clinical implications. Int J Cancer. 2022;151(8):1195–215.
Article CAS PubMed PubMed Central Google Scholar
Irvine AF, Waise S, Green EW, Stuart B, Thomas GJ. Characterising cancer-associated fibroblast heterogeneity in non-small cell lung cancer: a systematic review and meta-analysis. Sci Rep. 2021;11(1):3727.
Article CAS PubMed PubMed Central Google Scholar
Wang L, Li X, Ren Y, Geng H, Zhang Q, Cao L, et al. Cancer-associated fibroblasts contribute to cisplatin resistance by modulating ANXA3 in lung cancer cells. Cancer Sci. 2019;110(5):1609–20.
Article CAS PubMed PubMed Central Google Scholar
Navab R, Strumpf D, Bandarchi B, Zhu CQ, Pintilie M, Ramnarine VR, et al. Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. Proc Natl Acad Sci U S A. 2011;108(17):7160–5.
Article CAS PubMed PubMed Central Google Scholar
Wang L, Cao L, Wang H, Liu B, Zhang Q, Meng Z, et al. Cancer-associated fibroblasts enhance metastatic potential of lung cancer cells through IL-6/STAT3 signaling pathway. Oncotarget. 2017;8(44):76116–28.
Article PubMed PubMed Central Google Scholar
Linares J, Marín-Jiménez JA, Badia-Ramentol J, Calon A. Determinants and functions of CAFs secretome during cancer progression and therapy. Front Cell Dev Biol. 2020;8:621070.
Kharas MG, Lengner CJ, Al-Shahrour F, Bullinger L, Ball B, Zaidi S, et al. Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia. Nat Med. 2010;16(8):903–8.
Article CAS PubMed PubMed Central Google Scholar
Sakakibara S, Nakamura Y, Satoh H, Okano H. RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulations of neurons in mammalian CNS. J Neurosci. 2001;21(20):8091–107.
Article CAS PubMed PubMed Central Google Scholar
Sun J, Sheng W, Ma Y, Dong M. Potential role of Musashi-2 RNA-binding protein in cancer EMT. Onco Targets Ther. 2021;14:1969–80.
Article PubMed PubMed Central Google Scholar
Topchu I, Karnaukhov N, Mazitova A, Yugai V, Voloshin M, Tikhomirova M, et al. Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC). J Thorac Dis. 2021;13(3):1370–9.
Article PubMed PubMed Central Google Scholar
Kudinov AE, Deneka A, Nikonova AS, Beck TN, Ahn YH, Liu X, et al. Musashi-2 (MSI2) supports TGF-β signaling and inhibits claudins to promote non-small cell lung cancer (NSCLC) metastasis. Proc Natl Acad Sci U S A. 2016;113(25):6955–60.
Article CAS PubMed PubMed Central Google Scholar
Makhov P, Bychkov I, Faezov B, Deneka A, Kudinov A, Nicolas E, et al. Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC). Oncogenesis. 2021;10(3):29.
Article CAS PubMed PubMed Central Google Scholar
Samarelli AV, Masciale V, Aramini B, Coló GP, Tonelli R, Marchioni A, et al. Molecular mechanisms and cellular contribution from lung fibrosis to lung cancer development. Int J Mol Sci. 2021;22(22):12179.
Article CAS PubMed PubMed Central Google Scholar
Lánczky A, Győrffy B. Web-based survival analysis tool tailored for medical research (KMplot): development and implementation. J Med Internet Res. 2021;23(7):e27633.
Article PubMed PubMed Central Google Scholar
Dingerdissen HM, Torcivia-Rodriguez J, Hu Y, Chang TC, Mazumder R, Kahsay R. BioMuta and BioXpress: mutation and expression knowledgebases for cancer biomarker discovery. Nucleic Acids Res. 2018;46(D1):D1128–36.
Article CAS PubMed Google Scholar
Chandrashekar DS, Karthikeyan SK, Korla PK, Patel H, Shovon AR, Athar M, et al. UALCAN: an update to the integrated cancer data analysis platform. Neoplasia. 2022;25:18–27.
Article CAS PubMed PubMed Central Google Scholar
Arandkar S, Furth N, Elisha Y, Nataraj NB, van der Kuip H, Yarden Y, et al. Altered p53 functionality in cancer-associated fibroblasts contributes to their cancer-supporting features. Proc Natl Acad Sci U S A. 2018;115(25):6410–5.
Article CAS PubMed PubMed Central Google Scholar
Berens EB, Holy JM, Riegel AT, Wellstein A. A cancer cell spheroid assay to assess invasion in a 3D setting. J Vis Exp. 2015;(105):53409.
Na TY, Schecterson L, Mendonsa AM, Gumbiner BM. The functional activity of E-cadherin controls tumor cell metastasis at multiple steps. Proc Natl Acad Sci U S A. 2020;117(11):5931–7.
Article CAS PubMed PubMed Central Google Scholar
Jiang L, Xue S, Xu J, Fu X, Wei J, Zhang C. Prognostic value of Musashi 2 (MSI2) in cancer patients: a systematic review and meta-analysis. Front Oncol. 2022;12:969632.
Article CAS PubMed PubMed Central Google Scholar
Kim HC, Lee S, Song JW. Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients. Sci Rep. 2021;11(1):8312.
Article CAS PubMed PubMed Central Google Scholar
Yoo H, Jeong BH, Chung MJ, Lee KS, Kwon OJ, Chung MP. Risk factors and clinical characteristics of lung cancer in idiopathic pulmonary fibrosis: a retrospective cohort study. BMC Pulm Med. 2019;19(1):149.
Article PubMed PubMed Central Google Scholar
Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther. 2020;5(1):28.
Article PubMed PubMed Central Google Scholar
Lee KW, Yeo SY, Gong JR, Koo OJ, Sohn I, Lee WY, et al. PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Nat Commun. 2022;13(1):2793.
Article CAS PubMed PubMed Central Google Scholar
Xu H, Zhao J, Li J, Zhu Z, Cui Z, Liu R, et al. Cancer associated fibroblast-derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis. Cell Death Dis. 2022;13(5):478.
Article CAS PubMed PubMed Central Google Scholar
Wan K, Tu Z, Liu Z, Cai Y, Chen Y, Ling C. Upregulated osteoprotegerin expression promotes lung cancer cell invasion by increasing miR-20a expression. Exp Ther Med. 2021;22(2):846.
Article CAS PubMed PubMed Central Google Scholar
Zhang X, Meng A, Wang H, Yan X. High serum macrophage inflammatory protein-3α is associated with the early recurrence or metastasis of non-small cell lung cancer following primary pulmonary resection. Oncol Lett. 2014;8:948–52.
Article CAS PubMed PubMed Central Google Scholar
Li R, Ong SL, Tran LM, Jing Z, Liu B, Park SJ, et al. Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer. Sci Rep. 2020;10:377.
Article PubMed PubMed Central Google Scholar
Silva EM, Mariano VS, Pastrez PRA, Pinto MC, Castro AG, Syrjanen KJ, et al. High systemic IL-6 is associated with worse
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