Morgenstern M, Stiller SB, Lübbert P, Peikert CD, Dannenmaier S, Drepper F, et al. Definition of a high-confidence mitochondrial proteome at quantitative scale. Cell Rep. 2017;19(13):2836–52.
Article CAS PubMed PubMed Central Google Scholar
Araiso Y, Tsutsumi A, Qiu J, Imai K, Shiota T, Song J, et al. Structure of the mitochondrial import gate reveals distinct preprotein paths. Nature. 2019;575(7782):395–401.
Article CAS PubMed Google Scholar
Busch JD, Fielden LF, Pfanner N, Wiedemann N. Mitochondrial protein transport: Versatility of translocases and mechanisms. Mol Cell. 2023;83(6):890–910.
Article CAS PubMed Google Scholar
Makki A, Rehling P. Protein transport along the presequence pathway. Biol Chem. 2023;404(8–9):807–12.
Article CAS PubMed Google Scholar
Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, et al. Mapping protein interactions in the active TOM-TIM23 supercomplex. Nat Commun. 2021;12(1):5715.
Article CAS PubMed PubMed Central Google Scholar
Dekker PJT, Martin F, Maarse AC, Bömer U, Müller H, Guiard B, et al. The Tim core complex defines the number of mitochondrial translocation contact sites and can hold arrested preproteins in the absence of matrix Hsp70–Tim44. EMBO J. 1997;16(17):5408–19.
Article CAS PubMed PubMed Central Google Scholar
Chacinska A, Lind M, Frazier AE, Dudek J, Meisinger C, Geissler A, et al. Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell. 2005;120(6):817–29.
Article CAS PubMed Google Scholar
Mapa K, Sikor M, Kudryavtsev V, Waegemann K, Kalinin S, Seidel CAM, et al. The conformational dynamics of the mitochondrial Hsp70 chaperone. Mol Cell. 2010;38(1):89–100.
Article CAS PubMed Google Scholar
Ieva R, Schrempp SG, Opaliński Ł, Wollweber F, Höß P, Heißwolf AK, et al. Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane. Mol Cell. 2014;56(5):641–52.
Article CAS PubMed Google Scholar
Žárský V, Doležal P. Evolution of the Tim17 protein family. Biol Direct. 2016;11(1):54.
Article PubMed PubMed Central Google Scholar
Zhang Y, Ou X, Wang X, Sun D, Zhou X, Wu X, et al. Structure of the mitochondrial TIM22 complex from yeast. Cell Res. 2021;31(3):366–8.
Article CAS PubMed Google Scholar
Valpadashi A, Callegari S, Linden A, Neumann P, Ficner R, Urlaub H, et al. Defining the architecture of the human TIM22 complex by chemical crosslinking. FEBS Lett. 2021;595(2):157–68.
Article CAS PubMed Google Scholar
Qi L, Wang Q, Guan Z, Wu Y, Shen C, Hong S, et al. Cryo-EM structure of the human mitochondrial translocase TIM22 complex. Cell Res. 2021;31(3):369–72.
Article CAS PubMed Google Scholar
Beverly KN, Sawaya MR, Schmid E, Koehler CM. The Tim8-Tim13 complex has multiple substrate binding sites and binds cooperatively to Tim23. J Mol Biol. 2008;382(5):1144–56.
Article CAS PubMed PubMed Central Google Scholar
Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, et al. Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space. Mol Biol Evol. 2007;24(5):1149–60.
Article CAS PubMed Google Scholar
Pyrihová E, Motyčková A, Voleman L, Wandyszewska N, Fišer R, Seydlová G, et al. A single Tim translocase in the mitosomes of Giardia intestinalis illustrates convergence of protein import machines in anaerobic eukaryotes. Genome Biol Evol. 2018;10(10):2813–22.
Article PubMed PubMed Central Google Scholar
Harsman A, Schneider A. Mitochondrial protein import in trypanosomes: Expect the unexpected. Traffic. 2017;18(2):96–109.
Article CAS PubMed Google Scholar
Report on global sexually transmitted infection surveillance 2018. https://iris.who.int/handle/10665/277258. Accessed 14 Nov 2023.
Tachezy J, Makki A, Hrdý I. The hydrogenosome of Trichomonas vaginalis. J Eukaryot Microbiol. 2022;69(6):e12922.
Article CAS PubMed Google Scholar
Bradley PJ, Lahti CJ, Plumper E, Johnson PJ. Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import. EMBO J. 1997;16(12):3484–93.
Article CAS PubMed PubMed Central Google Scholar
Hrdy I, Tachezy J, Müller M. Metabolism of trichomonad hydrogenosomes. In: Tachezy J, editor. Hydrogenosome and Mitosomes: mitochondria of anaerobic eukaryotes. Cham: Springer; 2008. p. 114–45.
Rada P, Doležal P, Jedelský PL, Bursac D, Perry AJ, Šedinová M, et al. The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis. PLoS One. 2011;6(9):e24428.
Article CAS PubMed PubMed Central Google Scholar
Garg S, Stölting J, Zimorski V, Rada P, Tachezy J, Martin WF, et al. Conservation of transit peptide-Independent protein import into the mitochondrial and hydrogenosomal matrix. Genome Biol Evol. 2015;7(9):2716–26.
Article CAS PubMed PubMed Central Google Scholar
Makki A, Rada P, Žárský V, Kereïche S, Kováčik L, Novotný M, et al. Triplet-pore structure of a highly divergent TOM complex of hydrogenosomes in Trichomonas vaginalis. PLoS Biol. 2019;17(1):e3000098.
Article PubMed PubMed Central Google Scholar
Beltrán NC, Horváthová L, Jedelský PL, Šedinová M, Rada P, Marcinčiková M, et al. Iron-Induced Changes in the Proteome of Trichomonas vaginalis Hydrogenosomes. PLoS One. 2013;8(5): e65148.
Article PubMed PubMed Central Google Scholar
Zhou S, Ruan M, Li Y, Yang J, Bai S, Richter C, et al. Solution structure of the voltage-gated Tim23 channel in complex with a mitochondrial presequence peptide. Cell Res. 2021;31(7):821–4.
Article CAS PubMed Google Scholar
Demishtein-Zohary K, Günsel U, Marom M, Banerjee R, Neupert W, Azem A, et al. Role of Tim17 in coupling the import motor to the translocation channel of the mitochondrial presequence translocase. eLife. 2017;6:e22696.
Article PubMed PubMed Central Google Scholar
Demishtein-Zohary K, Marom M, Neupert W, Mokranjac D, Azem A. GxxxG motifs hold the TIM23 complex together. FEBS J. 2015;282(11):2178–86.
Article CAS PubMed Google Scholar
Stairs CW, Táborský P, Salomaki ED, Kolisko M, Pánek T, Eme L, et al. Anaeramoebae are a divergent lineage of eukaryotes that shed light on the transition from anaerobic mitochondria to hydrogenosomes. Curr Biol. 2021;31(24):5605–5612.e5.
Article CAS PubMed Google Scholar
Rehling P, Model K, Brandner K, Kovermann P, Sickmann A, Meyer HE, et al. Protein insertion into the mitochondrial inner membrane by a twin-pore translocase. Science. 2003;299(5613):1747–51.
Article CAS PubMed Google Scholar
Zárský V, Klimeš V, Pačes J, Vlček Č, Hradilová M, Beneš V, et al. The Mastigamoeba balamuthi geno
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