D. Hanahan, Hallmarks of Cancer: New dimensions. Cancer Discov. 12, 31–46 (2022)
Article CAS PubMed Google Scholar
A.K. Singh, J.P. McGuirk, CAR T cells: continuation in a revolution of immunotherapy. Lancet Oncol. 21, e168–e178 (2020)
Article CAS PubMed Google Scholar
S. Bagchi, R. Yuan, E.G. Engleman, Immune Checkpoint inhibitors for the treatment of Cancer: clinical impact and mechanisms of response and resistance. Annu. Rev. Pathol. 16, 223–249 (2021)
Article CAS PubMed Google Scholar
O. Demaria, S. Cornen, M. Daëron, Y. Morel, R. Medzhitov, E. Vivier, Harnessing innate immunity in cancer therapy. Nature. 574, 45–56 (2019)
Article CAS PubMed Google Scholar
Y. Yang, Cancer immunotherapy: harnessing the immune system to battle cancer. J. Clin. Invest. 125, 3335–3337 (2015)
Article PubMed PubMed Central Google Scholar
A. Kumar, C.A. Swain, L.A. Shevde, Informing the new developments and future of cancer immunotherapy. Cancer Metastasis Rev. 40, 549–562 (2021)
Article CAS PubMed Google Scholar
M.G. Morvan, L.L. Lanier, NK cells and cancer: you can teach innate cells new tricks. Nat. Rev. Cancer. 16, 7–19 (2016)
Article CAS PubMed Google Scholar
T. Timonen, J.R. Ortaldo, R.B. Herberman, Characteristics of human large granular lymphocytes and relationship to natural killer and K cells. J. Exp. Med. 153, 569–582 (1981)
Article CAS PubMed PubMed Central Google Scholar
M. Anft, P. Netter, D. Urlaub, I. Prager, S. Schaffner, C. Watzl, NK cell detachment from target cells is regulated by successful cytotoxicity and influences cytokine production. Cell. Mol. Immunol. 17, 347–355 (2020)
Article CAS PubMed Google Scholar
F. Fang, S. Xie, M. Chen, Y. Li, J. Yue, J. Ma et al., Advances in NK cell production. Cell. Mol. Immunol. 19, 460–481 (2022)
Article CAS PubMed PubMed Central Google Scholar
M.A. Caligiuri, Human natural killer cells. Blood. 112, 461–469 (2008)
Article CAS PubMed PubMed Central Google Scholar
C. Fauriat, E.O. Long, H.-G. Ljunggren, Y.T. Bryceson, Regulation of human NK-cell cytokine and chemokine production by target cell recognition. Blood. 115, 2167–2176 (2010)
Article CAS PubMed PubMed Central Google Scholar
J. Yu, A.G. Freud, M.A. Caligiuri, Location and cellular stages of NK cell development. Trends Immunol. 34 (2013). https://doi.org/10.1016/j.it.2013.07.005
P. Dogra, C. Rancan, W. Ma, M. Toth, T. Senda, D.J. Carpenter et al., Tissue determinants of human NK Cell Development, function, and Residence. Cell. 180, 749–763e13 (2020)
Article CAS PubMed PubMed Central Google Scholar
E. Vivier, D.H. Raulet, A. Moretta, M.A. Caligiuri, L. Zitvogel, L.L. Lanier et al., Innate or adaptive immunity? The Example of Natural Killer cells. Science. 331, 44–49 (2011)
Article CAS PubMed PubMed Central Google Scholar
S. Kumar, Natural killer cell cytotoxicity and its regulation by inhibitory receptors. Immunology. 154, 383–393 (2018)
Article CAS PubMed PubMed Central Google Scholar
F. Nimmerjahn, J.V. Ravetch, Fcgamma receptors as regulators of immune responses. Nat. Rev. Immunol. 8, 34–47 (2008)
Article CAS PubMed Google Scholar
J.S. Orange, Formation and function of the lytic NK-cell immunological synapse. Nat. Rev. Immunol. 8, 713–725 (2008)
Article CAS PubMed PubMed Central Google Scholar
I. Prager, C. Watzl, Mechanisms of natural killer cell-mediated cellular cytotoxicity. J. Leukoc. Biol. 105, 1319–1329 (2019)
Article CAS PubMed Google Scholar
M.J. Smyth, E. Cretney, J.M. Kelly, J.A. Westwood, S.E.A. Street, H. Yagita et al., Activation of NK cell cytotoxicity. Mol. Immunol. 42, 501–510 (2005)
Article CAS PubMed Google Scholar
I. Prager, C. Liesche, van H. Ooijen, D. Urlaub, Q. Verron, N. Sandström et al., NK cells switch from granzyme B to death receptor–mediated cytotoxicity during serial killing. J. Exp. Med. 216, 2113–2127 (2019)
Article CAS PubMed PubMed Central Google Scholar
D. Piccioli, S. Sbrana, E. Melandri, N.M. Valiante, Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J. Exp. Med. 195, 335–341 (2002)
Article CAS PubMed PubMed Central Google Scholar
B. Cózar, M. Greppi, S. Carpentier, E. Narni-Mancinelli, L. Chiossone, E. Vivier, Tumor-infiltrating natural killer cells. Cancer Discov. 11, 34–44 (2021)
E. Schlecker, N. Fiegler, A. Arnold, P. Altevogt, S. Rose-John, G. Moldenhauer et al., Metalloprotease-mediated Tumor Cell Shedding of B7-H6, the ligand of the natural killer cell–activating receptor NKp30. Cancer Res. 74, 3429–3440 (2014)
Article CAS PubMed Google Scholar
F. Ghiringhelli, C. Ménard, M. Terme, C. Flament, J. Taieb, N. Chaput et al., CD4 + CD25 + regulatory T cells inhibit natural killer cell functions in a transforming growth factor-beta-dependent manner. J. Exp. Med. 202, 1075–1085 (2005)
Article CAS PubMed PubMed Central Google Scholar
Á. Teijeira, S. Garasa, M. Gato, C. Alfaro, I. Migueliz, A. Cirella et al., CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce Neutrophil Extracellular traps that interfere with Immune cytotoxicity. Immunity. 52, 856–871e8 (2020)
Article CAS PubMed Google Scholar
X. Zheng, Y. Qian, B. Fu, D. Jiao, Y. Jiang, P. Chen et al., Mitochondrial fragmentation limits NK cell-based Tumor immunosurveillance. Nat. Immunol. 20, 1656–1667 (2019)
Article CAS PubMed Google Scholar
J. Ni, X. Wang, A. Stojanovic, Q. Zhang, M. Wincher, L. Bühler et al., Single-cell RNA sequencing of Tumor-infiltrating NK cells reveals that inhibition of transcription factor HIF-1α unleashes NK Cell activity. Immunity. 52, 1075–1087e8 (2020)
Article CAS PubMed Google Scholar
S.E. Keating, V. Zaiatz-Bittencourt, R.M. Loftus, C. Keane, K. Brennan, D.K. Finlay et al., Metabolic reprogramming supports IFN-γ production by CD56bright NK cells. J. Immunol. 196, 2552–2560 (2016)
Article CAS PubMed Google Scholar
M.G. Badur, C.M. Metallo, Reverse engineering the cancer metabolic network using flux analysis to understand drivers of human Disease. Metab. Eng. 45, 95–108 (2018)
Comments (0)