P.M. Aponte, A. Caicedo, Stemness in cancer: stem cells, cancer stem cells, and their microenvironment. Stem Cells Int. 2017, 5619472 (2017)
Article PubMed PubMed Central Google Scholar
A. Bobrie, S. Krumeich, F. Reyal, C. Recchi, L.F. Moita, M.C. Seabra, M. Ostrowski, C. Théry, Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res. 72, 4920–4930 (2012)
Article CAS PubMed Google Scholar
N. Bister, C. Pistono, B. Huremagic, J. Jolkkonen, R. Giugno, T. Malm, Hypoxia and extracellular vesicles: a review on methods, vesicular cargo and functions. J. Extracell. Vesicles 10, e12002 (2020)
Article PubMed PubMed Central Google Scholar
T. Bjørnetrø, K.R. Redalen, S. Meltzer, N.S. Thusyanthan, R. Samiappan, C. Jegerschöld, K.R. Handeland, A.H. Ree, An experimental strategy unveiling exosomal microRNAs 486-5p, 181a-5p and 30d-5p from hypoxic tumour cells as circulating indicators of high-risk rectal cancer. J. Extracell. Vesicles 8, 1567219 (2019)
Article PubMed PubMed Central Google Scholar
C. Bonnans, J. Chou, Z. Werb, Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15, 786–801 (2014)
Article CAS PubMed PubMed Central Google Scholar
O. Capik, R. Gumus, O.F. Karatas, Hypoxia-induced tumor exosomes promote angiogenesis through miR-1825/TSC2/mTOR axis in oral squamous cell carcinoma. Head Neck 45, 2259–2273 (2023)
F. Chen, B. Xu, J. Li, X. Yang, J. Gu, X. Yao, X. Sun, Hypoxic tumour cell-derived exosomal miR-340-5p promotes radioresistance of oesophageal squamous cell carcinoma via KLF10. J. Exp. Clin. Cancer Res. 40, 38 (2021)
Article CAS PubMed PubMed Central Google Scholar
K. Chen, Q. Wang, X. Liu, F. Wang, Y. Yang, X. Tian, Hypoxic pancreatic cancer derived exosomal miR-30b-5p promotes tumor angiogenesis by inhibiting GJA1 expression. Int. J. Biol. Sci. 18, 1220–1237 (2022)
Article CAS PubMed PubMed Central Google Scholar
X. Chen, X. Ying, X. Wang, X. Wu, Q. Zhu, Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization. Oncol. Rep. 38, 522–528 (2017)
Article CAS PubMed Google Scholar
X. Chen, J. Zhou, X. Li, X. Wang, Y. Lin, Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype. Cancer Lett. 435, 80–91 (2018)
Article CAS PubMed Google Scholar
X.J. Chen, C.H. Guo, Z.C. Wang, Y. Yang, Y.H. Pan, J.Y. Liang, M.G. Sun, L.S. Fan, L. Liang, W. Wang, Hypoxia-induced ZEB1 promotes cervical cancer immune evasion by strengthening the CD47-SIRPα axis. Cell Commun. Signal. 22, 15 (2024)
Article CAS PubMed PubMed Central Google Scholar
Y. Cheng, S. Li, Y. Hou, W. Wan, K. Wang, S. Fu, Y. Yuan, K. Yang, X. Ye, Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions. Cell Signal. 109, 110754 (2023)
Article CAS PubMed Google Scholar
C. Clemente-González, A. Carnero, Role of the hypoxic-secretome in seed and soil metastatic preparation. Cancers (Basel). 14(23), 5930 (2022)
G. Dai, Y. Yang, S. Liu, H. Liu, Hypoxic breast cancer cell-derived exosomal SNHG1 promotes breast cancer growth and angiogenesis via regulating miR-216b-5p/JAK2 axis. Cancer Manag. Res. 14, 123–133 (2022)
Article CAS PubMed PubMed Central Google Scholar
G. Deep, A. Jain, A. Kumar, C. Agarwal, S. Kim, W.M. Leevy, R. Agarwal, Exosomes secreted by prostate cancer cells under hypoxia promote matrix metalloproteinases activity at pre-metastatic niches. Mol. Carcinog. 59, 323–332 (2020)
Article CAS PubMed PubMed Central Google Scholar
G. Deep, G.K. Panigrahi, Hypoxia-induced signaling promotes prostate cancer progression: exosomes role as messenger of hypoxic response in tumor microenvironment. Crit. Rev. Oncog. 20, 419–434 (2015)
Article PubMed PubMed Central Google Scholar
C. Dong, X. Liu, H. Wang, J. Li, L. Dai, Z. Xu, Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin. Onco. Targets Ther. 12, 1947–1956 (2019)
Article CAS PubMed PubMed Central Google Scholar
Y. Duan, M. Zhou, B. Ye, K. Yue, F. Qiao, Y. Wang, Q. Lai, Y. Wu, J. Cao, X. Wang, C. Jing, Hypoxia-induced miR-5100 promotes exosome-mediated activation of cancer-associated fibroblasts and metastasis of head and neck squamous cell carcinoma. Cell Death Dis. 15, 215 (2024)
Article CAS PubMed PubMed Central Google Scholar
D.M. Gilkes, G.L. Semenza, D. Wirtz, Hypoxia and the extracellular matrix: drivers of tumour metastasis. Nat. Rev. Cancer 14, 430–439 (2014)
Article CAS PubMed PubMed Central Google Scholar
W. Gong, Y. Guo, H. Yuan, R. Chai, Z. Wan, B. Zheng, X. Hu, B. Chen, S. Gao, Q. Dai, P. Yu, S. Tu, Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3. Cancer Gene Ther. 30, 905–916 (2023)
Article CAS PubMed Google Scholar
W. Guo, T. Qiao, B. Dong, T. Li, Q. Liu, X. Xu, The effect of hypoxia-induced exosomes on anti-tumor immunity and its implication for immunotherapy. Front. Immunol. 13, 915985 (2022)
Article CAS PubMed PubMed Central Google Scholar
X. Guo, W. Qiu, Q. Liu, M. Qian, S. Wang, Z. Zhang, X. Gao, Z. Chen, H. Xue, G. Li, Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten pathways. Oncogene 37, 4239–4259 (2018)
Article CAS PubMed Google Scholar
Z. Guo, X. Wang, Y. Yang, W. Chen, K. Zhang, B. Teng, C. Huang, Q. Zhao, Z. Qiu, Hypoxic tumor-derived exosomal long noncoding RNA UCA1 promotes angiogenesis via miR-96-5p/AMOTL2 in pancreatic cancer. Mol. Ther. Nucleic Acids 22, 179–195 (2020)
Article CAS PubMed PubMed Central Google Scholar
D. Hanahan, Hallmarks of cancer: new dimensions. Cancer Discov. 12, 31–46 (2022)
Article CAS PubMed Google Scholar
D. Hanahan, R.A. Weinberg, Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011)
Article CAS PubMed Google Scholar
M. Harmati, E. Gyukity-Sebestyen, G. Dobra, L. Janovak, I. Dekany, O. Saydam, E. Hunyadi-Gulyas, I. Nagy, A. Farkas, T. Pankotai, Z. Ujfaludi, P. Horvath, F. Piccinini, M. Kovacs, T. Biro, K. Buzas, Small extracellular vesicles convey the stress-induced adaptive responses of melanoma cells. Sci. Rep. 9, 15329 (2019)
Article PubMed PubMed Central Google Scholar
K. Horie, K. Kawakami, Y. Fujita, M. Sugaya, K. Kameyama, K. Mizutani, T. Deguchi, M. Ito, Exosomes expressing carbonic anhydrase 9 promote angiogenesis. Biochem. Biophys. Res. Commun. 492, 356–361 (2017)
Article CAS PubMed Google Scholar
Y.L. Hsu, J.Y. Hung, W.A. Chang, Y.S. Lin, Y.C. Pan, P.H. Tsai, C.Y. Wu, P.L. Kuo, Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1. Oncogene 36, 4929–4942 (2017)
Article CAS PubMed Google Scholar
X. Huang, T. Trinh, A. Aljoufi, H.E. Broxmeyer, Hypoxia signaling pathway in stem cell regulation: good and evil. Curr. Stem Cell Rep. 4, 149–157 (2018)
Comments (0)