K. Komura, S.H. Jeong, K. Hinohara, F. Qu, X. Wang, M. Hiraki, H. Azuma, G.S. Lee, P.W. Kantoff, C.J. Sweeney, Proc. Natl. Acad. Sci. U. S. A. 113, 6259–6264 (2016). https://doi.org/10.1073/pnas.1600420113

I. Dagogo-Jack, A.T. Shaw, Nat. Rev. Clin. Oncol. 15, 81–94 (2018). https://doi.org/10.1038/nrclinonc.2017.166

M. Gerlinger, A.J. Rowan, S. Horswell, M. Math, J. Larkin, D. Endesfelder, E. Gronroos, P. Martinez, N. Matthews, A. Stewart, P. Tarpey, I. Varela, B. Phillimore, S. Begum, N.Q. McDonald, A. Butler, D. Jones, K. Raine, C. Latimer, C.R. Santos, M. Nohadani, A.C. Eklund, B. Spencer-Dene, G. Clark, L. Pickering, G. Stamp, M. Gore, Z. Szallasi, J. Downward, P.A. Futreal, C. Swanton, N. Engl. J. Med. 366, 883–892 (2012). https://doi.org/10.1056/NEJMoa1113205

A.B. Turke, K. Zejnullahu, Y.L. Wu, Y. Song, D. Dias-Santagata, E. Lifshits, L. Toschi, A. Rogers, T. Mok, L. Sequist, N.I. Lindeman, C. Murphy, S. Akhavanfard, B.Y. Yeap, Y. Xiao, M. Capelletti, A.J. Iafrate, C. Lee, J.G. Christensen, J.A. Engelman, P.A. Janne, Cancer Cell 17, 77–88 (2010). https://doi.org/10.1016/j.ccr.2009.11.022

H.E. Bhang, D.A. Ruddy, V. Krishnamurthy Radhakrishna, J.X. Caushi, R. Zhao, M.M. Hims, A.P. Singh, I. Kao, D. Rakiec, P. Shaw, M. Balak, A. Raza, E. Ackley, N. Keen, M.R. Schlabach, M. Palmer, R.J. Leary, D.Y. Chiang, W.R. Sellers, F. Michor, V.G. Cooke, J.M. Korn, F. Stegmeier, Nat. Med. 21, 440–448 (2015). https://doi.org/10.1038/nm.3841

B. Wu, X. Lu, H. Shen, X. Yuan, X. Wang, N. Yin, L. Sun, P. Shen, C. Hu, H. Jiang, D. Wang, Int. J. Cancer 146, 3369–3378 (2020). https://doi.org/10.1002/ijc.32961

S.S. Yadav, J.A. Stockert, V. Hackert, K.K. Yadav, A.K. Tewari, Urol. Oncol. 36, 349–360 https://doi.org/10.1016/j.urolonc.2018.05.008

Y.C.S. Ramon, M. Sese, C. Capdevila, T. Aasen, L. De Mattos-Arruda, S.J. Diaz-Cano, J. Hernandez-Losa, J. Castellvi, J. Mol. Med. (Berl) 98, 161–177 (2020). https://doi.org/10.1007/s00109-020-01874-2

A. Quintanal-Villalonga, J.M. Chan, H.A. Yu, D. Pe’er, C.L. Sawyers, T. Sen, C.M. Rudin, Nat. Rev. Clin. Oncol. 17, 360–371 (2020). https://doi.org/10.1038/s41571-020-0340-z

T. Graf, T. Enver, Nature 462, 587–594 (2009). https://doi.org/10.1038/nature08533

S. Laudato, A. Aparicio, F.G. Giancotti, Trends Cancer 5, 440–455 (2019). https://doi.org/10.1016/j.trecan.2019.05.008

C.E. Meacham, S.J. Morrison, Nature 501, 328–337 (2013). https://doi.org/10.1038/nature12624

H. Beltran, A. Hruszkewycz, H.I. Scher, J. Hildesheim, J. Isaacs, E.Y. Yu, K. Kelly, D. Lin, A. Dicker, J. Arnold, T. Hecht, M. Wicha, R. Sears, D. Rowley, R. White, J.L. Gulley, J. Lee, M. Diaz Meco, E.J. Small, M. Shen, K. Knudsen, D.W. Goodrich, T. Lotan, A. Zoubeidi, C.L. Sawyers, C.M. Rudin, M. Loda, T. Thompson, M.A. Rubin, A. Tawab-Amiri, W. Dahut, P.S. Nelson, Clin. Cancer. Res. 25, 6916–6924 (2019). https://doi.org/10.1158/1078-0432.CCR-19-1423

P.M. Schnepp, G. Shelley, J. Dai, N. Wakim, H. Jiang, A. Mizokami, E.T. Keller, Mol. Cancer Res. 18, 1290–1301 (2020). https://doi.org/10.1158/1541-7786.MCR-20-0051

D. Keresztes, A. Csizmarik, N. Nagy, O. Modos, T. Fazekas, T. Bracht, B. Sitek, K. Witzke, M. Puhr, S. Sevcenco, G. Kramer, S. Shariat, Z. Kuronya, L. Takacs, I. Tornyi, J. Lazar, B. Hadaschik, A. Laszik, M. Szucs, P. Nyirady, T. Szarvas, J. Cell Mol. Med. 26, 1332–1337 (2022). https://doi.org/10.1111/jcmm.17141

J. Zhang, S. Li, J. Zhang, W. Zhang, J. Jiang, H. Wu, E. Wu, Y. Feng, L. Yang, Z. Li, Cancer Lett. 545, 215829 (2022). https://doi.org/10.1016/j.canlet.2022.215829

M. Puhr, J. Hoefer, G. Schafer, H.H. Erb, S.J. Oh, H. Klocker, I. Heidegger, H. Neuwirt, Z. Culig, Am. J. Pathol. 181, 2188–2201 (2012). https://doi.org/10.1016/j.ajpath.2012.08.011

E.S. de Morree, R. Bottcher, R.J. van Soest, A. Aghai, C.M. de Ridder, A.A. Gibson, R.H. Mathijssen, H. Burger, E.A. Wiemer, A. Sparreboom, R. de Wit, W.M. van Weerden, Br. J. Cancer 115, 674–681 (2016). https://doi.org/10.1038/bjc.2016.251

W.M. van Weerden, C. Bangma, R. de Wit, Br. J. Cancer 100, 13–18 (2009). https://doi.org/10.1038/sj.bjc.6604822

S. Drapela, R. Fedr, O. Vacek, J. Remsik, K. Soucek, Methods Mol. Biol. 2543, 99–111 (2022). https://doi.org/10.1007/978-1-0716-2553-8_9

F.J. Hartmann, E.F. Simonds, S.C. Bendall, Sci. Rep. 8, 10770 (2018). https://doi.org/10.1038/s41598-018-28791-2

M. Bartoschek, N. Oskolkov, M. Bocci, J. Lovrot, C. Larsson, M. Sommarin, C.D. Madsen, D. Lindgren, G. Pekar, G. Karlsson, M. Ringner, J. Bergh, A. Bjorklund, K. Pietras, Nat. Commun. 9, 5150 (2018). https://doi.org/10.1038/s41467-018-07582-3

D. Boral, M. Vishnoi, H.N. Liu, W. Yin, M.L. Sprouse, A. Scamardo, D.S. Hong, T.Z. Tan, J.P. Thiery, J.C. Chang, D. Marchetti, Nat. Commun. 8, 196 (2017). https://doi.org/10.1038/s41467-017-00196-1

V. Pospichalova, J. Svoboda, Z. Dave, A. Kotrbova, K. Kaiser, D. Klemova, L. Ilkovics, A. Hampl, I. Crha, E. Jandakova, L. Minar, V. Weinberger, V. Bryja, J. Extracell. Vesicles 4, 25530 (2015). https://doi.org/10.3402/jev.v4.25530

J. Remsik, R. Fedr, J. Navratil, L. Bino, E. Slabakova, P. Fabian, M. Svoboda, K. Soucek, Br. J. Cancer 118, 813–819 (2018). https://doi.org/10.1038/bjc.2017.497

S.H. Liu, P.C. Shen, C.Y. Chen, A.N. Hsu, Y.C. Cho, Y.L. Lai, F.H. Chen, C.Y. Li, S.C. Wang, M. Chen, I.F. Chung, W.C. Cheng, Nucleic Acids Res. 48, D863–D870 (2020). https://doi.org/10.1093/nar/gkz964

A.D. Rouillard, G.W. Gundersen, N.F. Fernandez, Z. Wang, C.D. Monteiro, M.G. McDermott, A. Ma’ayan, Database (Oxford) 2016, (2016). https://doi.org/10.1093/database/baw100

Y. Perez-Riverol, J. Bai, C. Bandla, D. Garcia-Seisdedos, S. Hewapathirana, S. Kamatchinathan, D.J. Kundu, A. Prakash, A. Frericks-Zipper, M. Eisenacher, M. Walzer, S. Wang, A. Brazma, J.A. Vizcaino, Nucleic Acids Res. 50, D543–D552 (2022). https://doi.org/10.1093/nar/gkab1038

F. Fontana, E. Carollo, G.E. Melling, D.R.F. Carter, Cancers (Basel) 13, (2021). https://doi.org/10.3390/cancers13040749

S. Maacha, A.A. Bhat, L. Jimenez, A. Raza, M. Haris, S. Uddin, J.C. Grivel, Mol. Cancer 18, 55 (2019). https://doi.org/10.1186/s12943-019-0965-7

R. Tiwari, N. Manzar, B. Ateeq, Front. Mol. Biosci. 7, 130 (2020). https://doi.org/10.3389/fmolb.2020.00130

N. Jimenez, O. Reig, R. Montalbo, M. Mila-Guasch, L. Nadal-Dieste, G. Castellano, J.J. Lozano, I. Victoria, A. Font, A. Rodriguez-Vida, J. Carles, C. Suarez, M. Domenech, N. Sala-Gonzalez, P.L. Fernandez, L. Rodriguez-Carunchio, S. Diaz, A. Prat, M. Marin-Aguilera, B. Mellado, Front. Oncol. 10, 594023 (2020). https://doi.org/10.3389/fonc.2020.594023

K. Kolijn, E.I. Verhoef, G.J. van Leenders, Oncotarget 6, 24488–24498 (2015). https://doi.org/10.18632/oncotarget.4177

J.C. Symes, M. Kurin, N.E. Fleshner, J.A. Medin, Mol. Cancer Ther. 7, 3018–3028 (2008). https://doi.org/10.1158/1535-7163.MCT-08-0335

K. Hanrahan, A. O’Neill, M. Prencipe, J. Bugler, L. Murphy, A. Fabre, M. Puhr, Z. Culig, K. Murphy, R.W. Watson, Mol. Oncol. 11, 251–265 (2017). https://doi.org/10.1002/1878-0261.12030

M. Marin-Aguilera, J. Codony-Servat, O. Reig, J.J. Lozano, P.L. Fernandez, M.V. Pereira, N. Jimenez, M. Donovan, P. Puig, L. Mengual, R. Bermudo, A. Font, E. Gallardo, M.J. Ribal, A. Alcaraz, P. Gascon, B. Mellado, Mol. Cancer Ther. 13, 1270–1284 (2014). https://doi.org/10.1158/1535-7163.MCT-13-0775

K. Sivasubramaniyan, A. Harichandan, K. Schilbach, A.F. Mack, J. Bedke, A. Stenzl, L. Kanz, G. Niederfellner, H.J. Buhring, Glycobiology 25, 902–917 (2015). https://doi.org/10.1093/glycob/cwv032

M. Teodorczyk, S. Kleber, D. Wollny, J.P. Sefrin, B. Aykut, A. Mateos, P. Herhaus, I. Sancho-Martinez, O. Hill, C. Gieffers, J. Sykora, W. Weichert, C. Eisen, A. Trumpp, M.R. Sprick, F. Bergmann, T. Welsch, A. Martin-Villalba, Cell Death Differ. 22, 1192–1202 (2015). https://doi.org/10.1038/cdd.2014.217

T.Z. Tan, Q.H. Miow, Y. Miki, T. Noda, S. Mori, R.Y. Huang, J.P. Thiery, EMBO Mol. Med. 6, 1279–1293 (2014). https://doi.org/10.15252/emmm.201404208

R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA Cancer J. Clin. 72, 7–33 (2022). https://doi.org/10.3322/caac.21708

T. Karantanos, C.P. Evans, B. Tombal, T.C. Thompson, R. Montironi, W.B. Isaacs, Eur. Urol. 67, 470–479 (2015). https://doi.org/10.1016/j.eururo.2014.09.049

I.F. Tannock, R. de Wit, W.R. Berry, J. Horti, A. Pluzanska, K.N. Chi, S. Oudard, C. Theodore, N.D. James, I. Turesson, M.A. Rosenthal, M.A. Eisenberger, N. Engl. J. Med. 351, 1502–1512 (2004). https://doi.org/10.1056/NEJMoa040720

D.P. Petrylak, C.M. Tangen, M.H. Hussain, L. P.n. Jr, J.A. Jones, M.E. Taplin, P.A. Burch, D. Berry, C. Moinpour, M. Kohli, M.C. Benson, E.J. Small, D. Raghavan, E.D. Crawford, N. Engl. J. Med. https://doi.org/10.1056/NEJMoa041318

C.E. Kyriakopoulos, Y.H. Chen, M.A. Carducci, G. Liu, D.F. Jarrard, N.M. Hahn, D.H. Shevrin, R. Dreicer, M. Hussain, M. Eisenberger, M. Kohli, E.R. Plimack, N.J. Vogelzang, J. Picus, M.M. Cooney, J.A. Garcia, R.S. DiPaola, C.J. Sweeney, J. Clin. Oncol. 36, 1080–1087 (2018). https://doi.org/10.1200/JCO.2017.75.3657

C.J. Sweeney, Y.H. Chen, M. Carducci, G. Liu, D.F. Jarrard, M. Eisenberger, Y.N. Wong, N. Hahn, M. Kohli, M.M. Cooney, R. Dreicer, N.J. Vogelzang, J. Picus, D. Shevrin, M. Hussain, J.A. Garcia, R.S. DiPaola, N. Engl. J. Med. 373, 737–746 (2015). https://doi.org/10.1056/NEJMoa1503747

N.D. James, J.S. de Bono, M.R. Spears, N.W. Clarke, M.D. Mason, D.P. Dearnaley, A.W.S. Ritchie, C.L. Amos, C. Gilson, R.J. Jones, D. Matheson, R. Millman, G. Attard, S. Chowdhury, W.R. Cross, S. Gillessen, C.C. Parker, J.M. Russell, D.R. Berthold, C. Brawley, F. Adab, S. Aung, A.J. Birtle, J. Bowen, S. Brock, P. Chakraborti, C. Ferguson, J. Gale, E. Gray, M. Hingorani, P.J. Hoskin, J.F. Lester, Z.I. Malik, F. McKinna, N. McPhail, J. Money-Kyrle, J. O’Sullivan, O. Parikh, A. Protheroe, A. Robinson, N.N. Srihari, C. Thomas, J. Wagstaff, J. Wylie, A. Zarkar, M.K.B. Parmar, M.R. Sydes, S. Investigators, N. Engl. J. Med. 377, 338–351 (2017). https://doi.org/10.1056/NEJMoa1702900

B. Bumbaca, W. Li, Acta Pharm. Sin. B 8, 518–529 (2018). https://doi.org/10.1016/j.apsb.2018.04.007

W. Li, L. Qian, J. Lin, G. Huang, N. Hao, X. Wei, W. Wang, J. Liang, Oncotarget 8, 65143–65151 (2017). https://doi.org/10.18632/oncotarget.17821

G.S. Palapattu, C. Wu, C.R. Silvers, H.B. Martin, K. Williams, L. Salamone, T. Bushnell, L.S. Huang, Q. Yang, J. Huang, Prostate 69, 787–798 (2009). https://doi.org/10.1002/pros.20928

A. Hoshino, B. Costa-Silva, T.L. Shen, G. Rodrigues, A. Hashimoto, M. Tesic Mark, H. Molina, S. Kohsaka, A. Di Giannatale, S. Ceder, S. Singh, C. Williams, N. Soplop, K. Uryu, L. Pharmer, T. King, L. Bojmar, A.E. Davies, Y. Ararso, T. Zhang, H. Zhang, J. Hernandez, J.M. Weiss, V.D. Dumont-Cole, K. Kramer, L.H. Wexler, A. Narendran, G.K. Schwartz, J.H. Healey, P. Sandstrom, K.J. Labori, E.H. Kure, P.M. Grandgenett, M.A. Hollingsworth, M. de Sousa, S. Kaur, M. Jain, K. Mallya, S.K. Batra, W.R. Jarnagin, M.S. Brady, O. Fodstad, V. Muller, K. Pantel, A.J. Minn, M.J. Bissell, B.A. Garcia, Y. Kang, V.K. Rajasekhar, C.M. Ghajar, I. Matei, H. Peinado, J. Bromberg, D. Lyden, Nature 527, 329–335 (2015). https://doi.org/10.1038/nature15756

J. Li, N. Gao, Z. Gao, W. Liu, B. Pang, X. Dong, Y. Li, T. Fan, Front. Cell Dev. Biol. 9, 737962 (2021). https://doi.org/10.3389/fcell.2021.737962

N. Milman, L. Ginini, Z. Gil, Drug. Resist. Updat. 45, 1–12 (2019). https://doi.org/10.1016/j.drup.2019.07.003

A. Kumar, P. Kumar, M. Sharma, S. Kim, S. Singh, S.J. Kridel, G. Deep, Cancer Drug. Resist. 5, 612–624 (2022). https://doi.org/10.20517/cdr.2022.26

C. Corcoran, S. Rani, K. O’Brien, A. O’Neill, M. Prencipe, R. Sheikh, G. Webb, R. McDermott, W. Watson, J. Crown, L. O’Driscoll, PLoS One 7, e50999 (2012). https://doi.org/10.1371/journal.pone.0050999

S. Jorfi, E.A. Ansa-Addo, S. Kholia, D. Stratton, S. Valley, S. Lange, J. Inal, Sci. Rep. 5, 13006 (2015). https://doi.org/10.1038/srep13006

J. Jiang, J. Li, X. Zhou, X. Zhao, B. Huang, Y. Qin, Front. Oncol. 12, 864980 (2022). https://doi.org/10.3389/fonc.2022.864980

W. Zhang, M.L. Ding, J.N. Zhang, J.R. Qiu, Y.H. Shen, X.Y. Ding, L.F. Deng, W.B. Zhang, J. Zhu, Sci. Rep. 5, 9604 (2015). https://doi.org/10.1038/srep09604

A. Aloia, E. Petrova, S. Tomiuk, U. Bissels, O. Deas, M. Saini, F.M. Zickgraf, S. Wagner, S. Spaich, M. Sutterlin, A. Schneeweiss, M. Reitberger, S. Ruberg, B. Gerstmayer, D. Agorku, S. Knobel, A. Terranegra, M. Falleni, L. Soldati, M.R. Sprick, A. Trumpp, J.G. Judde, A. Bosio, S. Cairo, O. Hardt, Breast Cancer Res. 17, 146 (2015). https://doi.org/10.1186/s13058-015-0652-6

Y.W. Lou, P.Y. Wang, S.C. Yeh, P.K. Chuang, S.T. Li, C.Y. Wu, K.H. Khoo, M. Hsiao, T.L. Hsu, C.H. Wong, Proc. Natl. Acad. Sci. U. S. A. 111, 2482–2487 (2014). https://doi.org/10.1073/pnas.1400283111

Z. Noto, T. Yoshida, M. Okabe, C. Koike, M. Fathy, H. Tsuno, K. Tomihara, N. Arai, M. Noguchi, T. Nikaido, Oral Oncol 49, 787–795 (2013). https://doi.org/10.1016/j.oraloncology.2013.04.012

J. Cheng, K. Yang, Q. Zhang, Y. Yu, Q. Meng, N. Mo, Y. Zhou, X. Yi, C. Ma, A. Lei, Y. Liu, Sci. Rep. 6, 16993 (2016). https://doi.org/10.1038/srep16993

Y. Nakamura, Y. Miyata, T. Matsuo, Y. Shida, T. Hakariya, K. Ohba, T. Taima, A. Ito, T. Suda, S.I. Hakomori, S. Saito, H. Sakai, Glycoconjugate J. 36, 409–418 (2019). https://doi.org/10.1007/s10719-019-09882-2

R. Liu, Y. Chen, G. Liu, C. Li, Y. Song, Z. Cao, W. Li, J. Hu, C. Lu, Y. Liu, Cell Death Dis. 11, 797 (2020). https://doi.org/10.1038/s41419-020-02998-6

F. Liu, K. Bardhan, D. Yang, M. Thangaraju, V. Ganapathy, J.L. Waller, G.B. Liles, J.R. Lee, K. Liu, J. Bio.l Chem. 287, 25530–25540 (2012). https://doi.org/10.1074/jbc.M112.356279

Y. Du, X. Teng, N. Wang, X. Zhang, J. Chen, P. Ding, Q. Qiao, Q. Wang, L. Zhang, C. Yang, Z. Yang, Y. Chu, X. Du, X. Zhou, W. Hu, J. Bio.l Chem. 289, 2711–2724 (2014). https://doi.org/10.1074/jbc.M113.525501

M. Le Gallo, A. Poissonnier, P. Blanco, P. Legembre, Front. Immunol. 8, 1216 (2017). https://doi.org/10.3389/fimmu.2017.01216

T. Szarvas, S. Sevcenco, O. Modos, D. Keresztes, P. Nyirady, A. Csizmarik, R. Ristl, M. Puhr, M.J. Hoffmann, C. Niedworok, B. Hadaschik, A. Maj-Hes, S.F. Shariat, G. Kramer, BJU Int. 122, 695–704 (2018). https://doi.org/10.1111/bju.14415

C. Xu, M. Jung, M. Burkhardt, C. Stephan, D. Schnorr, S. Loening, K. Jung, M. Dietel, G. Kristiansen, Prostate 62, 224–232 (2005). https://doi.org/10.1002/pros.20134