aDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA;

bDepartment of Biostatistics, Harvard TH Chan Sch Public Health, Boston, MA;

cThe University of Texas Health Science Center at Houston, Houston, TX;

dCenter for Cardiovascular Disease Prevention, Cardiology Division, Brigham and Women's Hospital and Harvard Medical School, Boston, MA;

eDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH;

fLundquist Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles, CA;

gUniversity of California, Biostatistics, Epidemiology, and Computational Precision Health, Berkeley, CA;

hCardiovascular Imaging Research Center and Division of Cardiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA;

iDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH;

jDivision of Cardiovascular Medicine, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI;

kDivision of HIV, Infectious Diseases and Global Medicine, Department of Medicine, University of California, San Francisco, CA;

lDivision of Infectious Diseases, Department of Medicine, University of California, Los Angeles, CA; and

mDivision of Cardiology, Department of Medicine, University of California, San Francisco, CA.

Correspondence to: Joshua C. Cyktor, PhD, University of Pittsburgh, Department of Medicine, Division of Infectious Diseases, 3550 Terrace Street, Scaife Hall S814, Pittsburgh, PA 15261 (e-mail: [email protected]).

Supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number UM1 AI068634, UM1 AI068636, and UM1 AI106701. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. J.W.M. is a paid consultant to Gilead Sciences, receives research funding from Gilead Sciences through the University of Pittsburgh, receives compensation from Abound Bio, Inc., and owns shares options in MingMed, Galapagos, and Infectious Disease Connect, all unrelated to the current work. The remaining authors have no funding or conflicts of interest to disclose.

Clinical Trial Registration: AIDS Clinical Trails Group A5314, Division of AIDS # 12026. NCT01949116.