Associations of CD4 Cell Count Measures With Infection-Related and Infection-Unrelated Cancer Risk Among People With HIV

aDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada;

bLi Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada;

cDepartment of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada;

dICES, Toronto, Ontario, Canada;

eCanadian Cancer Society, Toronto, Ontario, Canada;

fBruyère Research Institute, Ottawa, Ontario, Canada;

gDepartment of Family Medicine, University of Ottawa, Ottawa, Ontario, Canada;

hInstitut du Savoir Montfort, Ottawa, Ontario, Canada;

iClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada;

jOttawa Hospital Research Institute, Ottawa, Ontario, Canada;

kOntario Health (Cancer Care Ontario), Toronto, Ontario, Canada;

lBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada;

mMcMaster University, Hamilton, Ontario, Canada;

nOntario HIV Treatment Network, Toronto, Ontario, Canada; and

oCanadian HIV/AIDS and Chronic Pain Society, Ottawa, Ontario, Canada.

Correspondence to: Ann N. Burchell, PhD, Department of Family and Community Medicine and MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, Canada M5B 1X1 (e-mail: [email protected]).

This study received funding from the Ontario HIV Treatment Network Endgame Game Changer Grant (No. EFP-1104-GC). I.A.N. was funded by a Canadian Institutes of Health Research Doctoral Award (No. 201710MDR) and the Canadian HIV Observational Cohort Scholar Award (No. 711352). A.N.B. is a Canada Research Chair in Sexually Transmitted Infection Prevention (Tier 2). During the study, A.N.B. received support from an Ontario HIV Treatment Network (OHTN) Endgame Leader award and a Non-Clinician Researcher award from the Department of Family and Community Medicine, Faculty of Medicine, University of Toronto. J.L.G. received support from the OHTN Endgame Student Leadership Award. C.E.K. was supported by CIHR New Investigator Award and Clinical Research Chair Award from the Faculty of Medicine University of Ottawa.

This work was presented at the Unity Health Toronto Cancer Research Symposium in Toronto, Ontario, Canada on September 28, 2023.

M.S. reports funding from the Canadian Institutes of Health Research, Air Canada, and the Greater Toronto Airports Authority. All other authors have no conflicts to declare.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jaids.com).

Parts of this material are based on data and/or information compiled and provided by the Canadian Institute for Health Information; Immigration, Refugees and Citizenship Canada (IRCC) current to March 2020; and Ontario Health (Cancer Care Ontario). The analyses, results, conclusions, opinion, views, and statements expressed herein are solely those of the authors and do not reflect those of the funding and data sources; no endorsement is intended or should be inferred. This study was supported by ICES, which is funded by an annual grant from the Ontario Ministry of Health (MOH) and the Ministry of Long-Term Care (MLTC). The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by ICES or the Ontario MOH and MLTC is intended or should be inferred.

The data set from this study is held securely in coded form at ICES. Although legal data sharing agreements between ICES and data providers (eg, health care organizations and government) prohibit ICES from making the data set publicly available, access may be granted to those who meet prespecified criteria for confidential access, available at www.ices.on.ca/DAS (e-mail: [email protected]). The full data set creation plan and underlying analytic code are available from the authors upon request, understanding that the computer programs may rely on coding templates or macros that are unique to ICES and are therefore either inaccessible or may require modification.

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