Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G et al (2021) The 2021 WHO classification of tumors of the Central Nervous System: a summary. Neuro Oncol 23(8):1231–1251

Article  CAS  PubMed  PubMed Central  Google Scholar 

Funakoshi Y, Sugihara Y, Uneda A, Nakashima T, Suzuki H (2023) Recent advances in the molecular understanding of medulloblastoma. Cancer Sci 114(3):741–749

Article  CAS  PubMed  Google Scholar 

Sharma T, Schwalbe EC, Williamson D, Sill M, Hovestadt V, Mynarek M, Rutkowski S, Robinson GW, Gajjar A, Cavalli F et al (2019) Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes. Acta Neuropathol 138(2):309–326

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hovestadt V, Ayrault O, Swartling FJ, Robinson GW, Pfister SM, Northcott PA (2020) Medulloblastomics revisited: biological and clinical insights from thousands of patients. Nat Rev Cancer 20(1):42–56

Article  CAS  PubMed  Google Scholar 

Williamson D, Schwalbe EC, Hicks D, Aldinger KA, Lindsey JC, Crosier S, Richardson S, Goddard J, Hill RM, Castle J et al (2022) Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development. Cell Rep 40(5):111162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ray S, Chaturvedi NK, Bhakat KK, Rizzino A, Mahapatra S (2021) Subgroup-Specific Diagnostic, Prognostic, and predictive markers influencing Pediatric Medulloblastoma Treatment. Diagnostics (Basel) 12(1)

Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K et al (2022) Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis. Nature 612(7941):787–794

Article  CAS  PubMed  Google Scholar 

Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR et al (2019) Resolving medulloblastoma cellular architecture by single-cell genomics. Nature 572(7767):74–79

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leary SES, Packer RJ, Li Y, Billups CA, Smith KS, Jaju A, Heier L, Burger P, Walsh K, Han Y et al (2021) Efficacy of Carboplatin and Isotretinoin in Children with High-risk Medulloblastoma: a Randomized Clinical Trial from the children’s Oncology Group. JAMA Oncol 7(9):1313–1321

Article  PubMed  PubMed Central  Google Scholar 

Martinez de Estibariz I, Jakjimovska A, Illarregi U, Martin-Guerrero I, Gutierrez-Camino A, Lopez-Lopez E, Bilbao-Aldaiturriaga N (2023) The Role of the Dysregulation of Long Non-Coding and Circular RNA Expression in Medulloblastoma: A Systematic Review. Cancers (Basel) 15(19)

Joshi P, Katsushima K, Zhou R, Meoded A, Stapleton S, Jallo G, Raabe E, Eberhart CG, Perera RJ (2019) The therapeutic and diagnostic potential of regulatory noncoding RNAs in medulloblastoma. Neurooncol Adv 1(1):vdz023

PubMed  PubMed Central  Google Scholar 

Katsushima K, Joshi K, Perera RJ (2023) Diagnostic and therapeutic potential of circular RNA in brain tumors. Neurooncol Adv 5(1):vdad063

PubMed  PubMed Central  Google Scholar 

Qin N, Paisana E, Picard D, Leprivier G, Langini M, Custodia C, Cascao R, Conrad C, Peitzsch M, Stefanski A et al (2023) The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma. J Neurooncol 165(2):329–342

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kesherwani V, Shukla M, Coulter DW, Sharp JG, Joshi SS, Chaturvedi NK (2020) Long non-coding RNA profiling of pediatric Medulloblastoma. BMC Med Genomics 13(1):87

Article  CAS  PubMed  PubMed Central  Google Scholar 

Katsushima K, Lee B, Kunhiraman H, Zhong C, Murad R, Yin J, Liu B, Garancher A, Gonzalez-Gomez I, Monforte HL et al (2021) The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas. Neuro Oncol 23(4):572–585

Article  CAS  PubMed  Google Scholar 

Lee B, Katsushima K, Pokhrel R, Yuan M, Stapleton S, Jallo G, Wechsler-Reya RJ, Eberhart CG, Ray A, Perera RJ (2022) The long non-coding RNA SPRIGHTLY and its binding partner PTBP1 regulate exon 5 skipping of SMYD3 transcripts in group 4 medulloblastomas. Neurooncol Adv 4(1):vdac120

PubMed  PubMed Central  Google Scholar 

Katsushima K, Pokhrel R, Mahmud I, Yuan M, Murad R, Baral P, Zhou R, Chapagain P, Garrett T, Stapleton S et al (2023) The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas. Acta Neuropathol Commun 11(1):38

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang Z, Mei W, Qu C, Lu J, Shang L, Cao F, Li F (2022) Role of m6A writers, erasers and readers in cancer. Exp Hematol Oncol 11(1):45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen L, He Y, Zhu J, Zhao S, Qi S, Chen X, Zhang H, Ni Z, Zhou Y, Chen G et al (2023) The roles and mechanism of m(6)a RNA methylation regulators in cancer immunity. Biomed Pharmacother 163:114839

Article  CAS  PubMed  Google Scholar 

Yang Y, Hsu PJ, Chen YS, Yang YG (2018) Dynamic transcriptomic m(6)a decoration: writers, erasers, readers and functions in RNA metabolism. Cell Res 28(6):616–624

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Miao L, Lin H, Zhuo Z, He J (2022) The role of m6A modification in pediatric cancer. Biochim Biophys Acta Rev Cancer 1877(2):188691

Article  CAS  PubMed  Google Scholar 

Wu WJ, Xiao F, Xiong Y, Sun GF, Guo Y, Zhou X, Hu GW, Huang K, Guo H (2023) N6-methyladenosine (m6A)-connected lncRNAs are linked to survival and immune infiltration in glioma patients. Biosci Rep 43(5)

Li R, Chen H, Li C, Qi Y, Zhao K, Wang J, You C, Huang H (2023) The prognostic value and immune landscaps of m6A/m5C-related lncRNAs signature in the low grade glioma. BMC Bioinformatics 24(1):274

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma A, Wang Y, Ge F, Chen P, Dakal TC, Carro MS, Schmidt-Wolf IGH, Maciaczyk J (2023) Systematic integration of m6A regulators and autophagy-related genes in combination with long non-coding RNAs predicts survival in glioblastoma multiforme. Sci Rep 13(1):17232

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Zhang W, Yan Z, Zhang M (2023) Comprehensive analyses indicated the association between m6A related long non-coding RNAs and various pathways in glioma. Cancer Med 12(1):760–788

Article  CAS  PubMed  Google Scholar 

Cao X, Geng Q, Fan D, Wang Q, Wang X, Zhang M, Zhao L, Jiao Y, Deng T, Liu H et al (2023) M(6)a methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion. Mol Cancer 22(1):42

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie P, Yan H, Gao Y, Li X, Zhou DB, Liu ZQ (2022) Construction of m6A-Related lncRNA prognostic signature model and Immunomodulatory Effect in Glioblastoma Multiforme. Front Oncol 12:920926

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ni W, Yao S, Zhou Y, Liu Y, Huang P, Zhou A, Liu J, Che L, Li J (2019) Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m(6)a reader YTHDF3. Mol Cancer 18(1):143

Article  PubMed  PubMed Central  Google Scholar 

Cui Q, Shi H, Ye P, Li L, Qu Q, Sun G, Sun G, Lu Z, Huang Y, Yang CG et al (2017) M(6)a RNA methylation regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem cells. Cell Rep 18(11):2622–2634

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong F, Qin X, Wang B, Li Q, Hu J, Cheng X, Guo D, Cheng F, Fang C, Tan Y et al (2021) ALKBH5 facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to generate an immunosuppressive Tumor Microenvironment. Cancer Res 81(23):5876–5888

Article