Verdin E (2015) NAD+ in aging, metabolism, and neurodegeneration. Science 350(6265):1208
Article CAS PubMed Google Scholar
Coleman MP, Hoke A (2020) Programmed axon degeneration: from mouse to mechanism to medicine. Nat Rev Neurosci 21(4):183–196
Article CAS PubMed PubMed Central Google Scholar
Conforti L, Gilley J, Coleman MP (2014) Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci 15(6):394–409
Article CAS PubMed Google Scholar
Tribble JR, Hui F, Quintero H, El Hajji S, Bell K, Di Polo A et al (2023) Neuroprotection in glaucoma: mechanisms beyond intraocular pressure lowering. Mol Aspects Med 92:101193
Article CAS PubMed Google Scholar
Lautrup S, Sinclair DA, Mattson MP, Fang EF (2019) NAD(+) in brain aging and neurodegenerative disorders. Cell Metab 30(4):630–655
Article CAS PubMed PubMed Central Google Scholar
Xie N, Zhang L, Gao W, Huang C, Huber PE, Zhou X et al (2020) NAD(+) metabolism: pathophysiologic mechanisms and therapeutic potential. Signal Transduct Target Ther 5(1):227
Article CAS PubMed PubMed Central Google Scholar
Cho D-H, Nakamura T, Lipton SA (2010) Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci 67(20):3435–3447
Article CAS PubMed PubMed Central Google Scholar
Knott AB, Bossy-Wetzel E (2008) Impairing the mitochondrial fission and fusion balance: a new mechanism of neurodegeneration. Ann N Y Acad Sci 1147(1):283–292
Article CAS PubMed PubMed Central Google Scholar
Johri A, Beal MF (2012) Mitochondrial dysfunction in neurodegenerative diseases. J Pharmacol Exp Ther 342(3):619–630
Article CAS PubMed PubMed Central Google Scholar
Lopez-Domenech G, Higgs NF, Vaccaro V, Ros H, Arancibia-Carcamo IL, MacAskill AF et al (2016) Loss of dendritic complexity precedes neurodegeneration in a mouse model with disrupted mitochondrial distribution in mature dendrites. Cell Rep 17(2):317–327
Article CAS PubMed PubMed Central Google Scholar
Wilson DM III, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I (2023) Hallmarks of neurodegenerative diseases. Cell 186(4):693–714
Article CAS PubMed Google Scholar
Tham Y-C, Li X, Wong TY, Quigley HA, Aung T, Cheng C-Y (2014) Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology 121(11):2081–2090
Williams PA, Harder JM, Foxworth NE, Cochran KE, Philip VM, Porciatti V et al (2017) Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice. Science 355(6326):756
Article CAS PubMed PubMed Central Google Scholar
Tribble JR, Vasalauskaite A, Redmond T, Young RD, Hassan S, Fautsch MP et al (2019) Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma. Brain Commun. 1(1):fcz035
Article PubMed PubMed Central Google Scholar
Tribble JR, Otmani A, Sun S, Ellis SA, Cimaglia G, Vohra R et al (2021) Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction. Redox Biol 43:101988
Article CAS PubMed PubMed Central Google Scholar
Chou T-H, Romano GL, Amato R, Porciatti V (2020) Nicotinamide-rich diet in DBA/2J mice preserves retinal ganglion cell metabolic function as assessed by PERG adaptation to flicker. Nutrients 12(7):1910
Article CAS PubMed PubMed Central Google Scholar
Kouassi Nzoughet J, Chao de la Barca JM, Guehlouz K, Leruez S, Coulbault L, Allouche S et al (2019) Nicotinamide deficiency in primary open-angle glaucoma. Invest Ophthalmol Vis Sci 60(7):2509–2514
Petriti B, Rabiolo A, Chau KY, Williams PA, Montesano G, Lascaratos G et al (2024) Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss. Nat Med. https://doi.org/10.1038/s41591-024-03068-6
Article PubMed PubMed Central Google Scholar
Hui F, Tang J, Williams PA, McGuinness MB, Hadoux X, Casson RJ et al (2020) Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial. Clin Exp Ophthalmol 183:88
Tribble JR, Otmani A, Kokkali E, Lardner E, Morgan JE, Williams PA (2021) Retinal ganglion cell degeneration in a rat magnetic bead model of ocular hypertensive glaucoma. Transl Vis Sci Technol 10(1):21
Article PubMed PubMed Central Google Scholar
Williams PA, Morgan JE, Votruba M (2010) Opa1 deficiency in a mouse model of dominant optic atrophy leads to retinal ganglion cell dendropathy. Brain 133(10):2942–2951
Cimaglia G, Bevan RJ, Want A, Morgan JE (2023) Gene gun DiOlistic labelling of retinal ganglion cells. In: Mead B (ed) Retinal ganglion cells: methods and protocols. Springer, New York, pp 33–40
Belforte N, Agostinone J, Alarcon-Martinez L, Villafranca-Baughman D, Dotigny F, Cueva Vargas JL et al (2021) AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma. Mol Neurodegener 16(1):43
Article CAS PubMed PubMed Central Google Scholar
Tribble JR, Cross SD, Samsel PA, Sengpiel F, Morgan JE (2014) A novel system for the classification of diseased retinal ganglion cells. Vis Neurosci 31(6):373–380
Chong J, Wishart DS, Xia J (2019) Using MetaboAnalyst 4.0 for comprehensive and integrative metabolomics data analysis. Current Protocols Bioinform. 68(1):e86
Chong J, Soufan O, Li C, Caraus I, Li S, Bourque G et al (2018) MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis. Nucl. Acids Res. 46(W1):W486–W494
Article CAS PubMed PubMed Central Google Scholar
Tribble JR, Kokkali E, Otmani A, Plastino F, Lardner E, Vohra R et al (2021) When is a control not a control? Reactive microglia occur throughout the control contralateral pathway of retinal ganglion cell projections in experimental glaucoma. Transl Vis Sci Technol 10(1):22
Article PubMed PubMed Central Google Scholar
Tribble JR, Hagstrom A, Jusseaume K, Lardner E, Wong RC, Stalhammar G et al (2023) NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve. Acta Neuropathol Commun 11(1):18
Article CAS PubMed PubMed Central Google Scholar
Morgan JE, Datta AV, Erichsen JT, Albon J, Boulton ME, (eds) (2006) Retinal ganglion cell remodelling in experimental glaucoma. In: Retinal degenerative diseases, 2006. Springer, Boston
Williams PA, Howell GR, Barbay JM, Braine CE, Sousa GL, John SW et al (2013) Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma. PLoS ONE 8(8):e72282
Article CAS PubMed PubMed Central Google Scholar
Weber AJ, Harman CD (2005) Structure–function relations of parasol cells in the normal and glaucomatous primate retina. Invest Ophthalmol Vis Sci 46(9):3197–3207
Comments (0)