Phylloquinone improves endothelial function, inhibits cellular senescence, and vascular inflammation

Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012;12(11):93. https://doi.org/10.1186/1475-2891-11-93.

Article  CAS  Google Scholar 

Beulens JW, Booth SL, van den Heuvel EG, Stoecklin E, Baka A, Vermeer C. The role of menaquinones (vitamin K2) in human health. Br J Nutr. 2013;110(8):1357–68. https://doi.org/10.1017/S0007114513001013.

Article  CAS  PubMed  Google Scholar 

Booth SL. Roles for vitamin K beyond coagulation. Annu Rev Nutr. 2009;29:89–110. https://doi.org/10.1146/annurev-nutr-080508-141217.

Article  CAS  PubMed  Google Scholar 

Willems BA, Vermeer C, Reutelingsperger CP, Schurgers LJ. The realm of vitamin K dependent proteins: shifting from coagulation toward calcification. Mol Nutr Food Res. 2014;58(8):1620–35. https://doi.org/10.1002/mnfr.201300743.

Article  CAS  PubMed  Google Scholar 

van den Heuvel EG, van Schoor NM, Lips P, Magdeleyns EJ, Deeg DJ, Vermeer C, den Heijer M. Circulating uncarboxylated matrix Gla protein, a marker of vitamin K status, as a risk factor of cardiovascular disease. Maturitas. 2014;77(2):137–41. https://doi.org/10.1016/j.maturitas.2013.10.008.

Article  CAS  PubMed  Google Scholar 

Chatron N, Hammed A, Benoît E, Lattard V. Structural insights into phylloquinone (vitamin K1), menaquinone (MK4, MK7), and menadione (vitamin K3) binding to VKORC1. Nutrients. 2019;11(1):67. https://doi.org/10.3390/nu11010067.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S. Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells. J Biol Chem. 2006;281(25):16927–34. https://doi.org/10.1074/jbc.M600896200.

Article  CAS  PubMed  Google Scholar 

Ohsaki Y, Shirakawa H, Miura A, Giriwono PE, Sato S, Ohashi A, Iribe M, Goto T, Komai M. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. J Nutr Biochem. 2010;21(11):1120–6. https://doi.org/10.1016/j.jnutbio.2009.09.011.

Article  CAS  PubMed  Google Scholar 

Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science. 2012;336(6086):1306–10. https://doi.org/10.1126/science.1218632.

Article  CAS  PubMed  Google Scholar 

Tirapelli CR, Mingatto FE, de Oliveira AM. Vitamin K(1) prevents the effect of hypoxia on phenylephrine-induced contraction in the carotid artery. Pharmacology. 2002;66(1):36–43. https://doi.org/10.1159/000063255.

Article  CAS  PubMed  Google Scholar 

Tasatargil A, Cadir B, Dalaklioglu S, Yurdakonar E, Caglar S, Turkay C. Effects of vitamin K1 supplementation on vascular responsiveness and oxidative stress in a rat femoral osteotomy model. Cell Biochem Funct. 2007;25(5):485–90. https://doi.org/10.1002/cbf.1335.

Article  CAS  PubMed  Google Scholar 

Kolahi S, Pourghassem Gargari B, Mesgari Abbasi M, Asghari Jafarabadi M, Ghamarzad Shishavan N. Effects of phylloquinone supplementation on lipid profile in women with rheumatoid arthritis: a double blind placebo controlled study. Nutr Res Pract. 2015;9(2):186–91. https://doi.org/10.4162/nrp.2015.9.2.186.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan MH, Maresz K, Lee PS, Wu JC, Ho CT, Popko J, Mehta DS, Stohs SJ, Badmaev V. Inhibition of TNF-α, IL-1α, and IL-1β by pretreatment of human monocyte-derived macrophages with menaquinone-7 and cell activation with TLR agonists in vitro. J Med Food. 2016;19(7):663–9. https://doi.org/10.1089/jmf.2016.0030.

Article  CAS  PubMed  Google Scholar 

Kieronska-Rudek A, Kij A, Kaczara P, Tworzydlo A, Napiorkowski M, Sidoryk K, Chlopicki S. Exogenous vitamins K exert anti-inflammatory effects dissociated from their role as substrates for synthesis of endogenous MK-4 in murine macrophages cell line. Cells. 2021;10(7):1571. https://doi.org/10.3390/cells10071571.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Upadhyay A, Fontes FL, Gonzalez-Juarrero M, McNeil MR, Crans DC, Jackson M, Crick DC. Partial saturation of menaquinone in Mycobacterium tuberculosis: function and essentiality of a novel reductase. Men J ACS Cent Sci. 2015;1(6):292–302. https://doi.org/10.1021/acscentsci.5b00212.

Article  CAS  Google Scholar 

Koehn JT, Crick DC, Crans DC. Synthesis and characterization of partially and fully saturated menaquinone derivatives. ACS Omega. 2018;3(11):14889–901. https://doi.org/10.1021/acsomega.8b02620.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cenci U, Qiu H, Pillonel T, Cardol P, Remacle C, Colleoni C, Kadouche D, Chabi M, Greub G, Bhattacharya D, Ball SG. Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida. Sci Rep. 2018;8(1):15243. https://doi.org/10.1038/s41598-018-33663-w.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Conly JM, Stein K. The production of menaquinones (vitamin K2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Prog Food Nutr Sci. 1992;16(4):307–43.

CAS  PubMed  Google Scholar 

Harshman SG, Shea MK, Fu X, Grusak MA, Smith D, Lamon-Fava S, Kuliopulos A, Greenberg A, Booth SL. Atorvastatin decreases renal menaquinone-4 formation in C57BL/6 male mice. J Nutr. 2019;149(3):416–21. https://doi.org/10.1093/jn/nxy290.

Article  PubMed  PubMed Central  Google Scholar 

Okano T, Shimomura Y, Yamane M, Suhara Y, Kamao M, Sugiura M, Nakagawa K. Conversion of phylloquinone (vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice. J Biol Chem. 2008;283(17):11270–9. https://doi.org/10.1074/jbc.M702971200.

Article  CAS  PubMed  Google Scholar 

Thijssen HH, Vervoort LM, Schurgers LJ, Shearer MJ. Menadione is a metabolite of oral vitamin K. Br J Nutr. 2006;95(2):260–6. https://doi.org/10.1079/bjn20051630.

Article  CAS  PubMed  Google Scholar 

Hirota Y, Tsugawa N, Nakagawa K, Suhara Y, Tanaka K, Uchino Y, Takeuchi A, Sawada N, Kamao M, Wada A, Okitsu T, Okano T. Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. J Biol Chem. 2013;288(46):33071–80. https://doi.org/10.1074/jbc.M113.477356.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ronden JE, Drittij-Reijnders MJ, Vermeer C, Thijssen HH. Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Biochim Biophys Acta. 1998;1379(1):69–75. https://doi.org/10.1016/s0304-4165(97)00089-5.

Article  CAS  PubMed  Google Scholar 

Hegarty JM, Yang H, Chi NC. UBIAD1-mediated vitamin K2 synthesis is required for vascular endothelial cell survival and development. Development. 2013;140(8):1713–9. https://doi.org/10.1242/dev.093112.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bar A, Kus K, Manterys A, Proniewski B, Sternak M, Przyborowski K, Moorlag M, Sitek B, Marczyk B, Jasztal A, Skórka T, Franczyk-Żarów M, Kostogrys RB, Chlopicki S. Vitamin K2-MK-7 improves nitric oxide-dependent endothelial function in ApoE/LDLR−/− mice. Vascul Pharmacol. Vascul Pharmacol. 2019;122–123:106581. https://doi.org/10.1016/j.vph.2019.106581.

Article  CAS  PubMed  Google Scholar 

Juanola-Falgarona M, Salas-Salvadó J, Martínez-González MÁ, Corella D, Estruch R, Ros E, Fitó M, Arós F, Gómez-Gracia E, Fiol M, Lapetra J, Basora J, Lamuela-Raventós RM, Serra-Majem L, Pintó X, Muñoz MÁ, Ruiz-Gutiérrez V, Fernández-Ballart J, Bulló M. Dietary intake of vitamin K is inversely associated with mortality risk. J Nutr. 2014;144(5):743–50. https://doi.org/10.3945/jn.113.187740. Erratum in: J Nutr. 2016 Mar;146(3):653.

Geleijnse JM, Vermeer C, Grobbee DE, Schurgers LJ, Knapen MH, van der Meer IM, Hofman A, Witteman JC. Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study. J Nutr. 2004;134(11):3100–5.

Comments (0)

No login
gif