Azziz R, Carmina E, Chen Z, Dunaif A, Laven JS, Legro RS, et al. Polycystic ovary syndrome. Nat Reviews Disease Primers. 2016;2:16057. https://doi.org/10.1038/nrdp.2016.57.
Dumesic DA, Oberfield SE, Stener-Victorin E, Marshall JC, Laven JS, Legro RS. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015;36(5):487–525. https://doi.org/10.1210/er.2015-1018.
Article CAS PubMed PubMed Central Google Scholar
Hoeger KM, Dokras A, Piltonen T. Update on PCOS: consequences, challenges, and Guiding Treatment. J Clin Endocrinol Metab. 2021;106(3):e1071–83. https://doi.org/10.1210/clinem/dgaa839.
Thackray VG, Sex. Microbes, and polycystic ovary syndrome. Trends in endocrinology and metabolism. TEM. 2019;30(1):54–65. https://doi.org/10.1016/j.tem.2018.11.001.
Article CAS PubMed Google Scholar
Legro RS, Driscoll D, Strauss JF 3rd, Fox J, Dunaif A. Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci USA. 1998;95(25):14956–60. https://doi.org/10.1073/pnas.95.25.14956.
Article CAS PubMed PubMed Central Google Scholar
Dapas M, Lin FTJ, Nadkarni GN, Sisk R, Legro RS, Urbanek M, et al. Distinct subtypes of polycystic ovary syndrome with novel genetic associations: an unsupervised, phenotypic clustering analysis. PLoS Med. 2020;17(6):e1003132. https://doi.org/10.1371/journal.pmed.1003132.
Article CAS PubMed PubMed Central Google Scholar
Day F, Karaderi T, Jones MR, Meun C, He C, Drong A, et al. Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria. PLoS Genet. 2018;14(12):e1007813. https://doi.org/10.1371/journal.pgen.1007813.
Article CAS PubMed PubMed Central Google Scholar
Fan Y, Pedersen O. Gut microbiota in human metabolic health and disease. Nat Rev Microbiol. 2021;19(1):55–71. https://doi.org/10.1038/s41579-020-0433-9.
Article CAS PubMed Google Scholar
Vrieze A, Van Nood E, Holleman F, Salojärvi J, Kootte RS, Bartelsman JF, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913–e67. https://doi.org/10.1053/j.gastro.2012.06.031.
Article CAS PubMed Google Scholar
Tremellen K, Pearce K. Dysbiosis of gut microbiota (DOGMA)--a novel theory for the development of polycystic ovarian syndrome. Med Hypotheses. 2012;79(1):104–12. https://doi.org/10.1016/j.mehy.2012.04.016.
Wang L, Zhou J, Gober HJ, Leung WT, Huang Z, Pan X, et al. Alterations in the intestinal microbiome associated with PCOS affect the clinical phenotype. Biomed Pharmacotherapy = Biomedecine Pharmacotherapie. 2021;133:110958. https://doi.org/10.1016/j.biopha.2020.110958.
Article CAS PubMed Google Scholar
Giampaolino P, Foreste V, Di Filippo C, Gallo A, Mercorio A, Serafino P, et al. Microbiome and PCOS: state-of-art and future aspects. Int J Mol Sci. 2021;22(4). https://doi.org/10.3390/ijms22042048.
Torres PJ, Siakowska M, Banaszewska B, Pawelczyk L, Duleba AJ, Kelley ST, Thackray VG. Gut Microbial Diversity in Women with Polycystic Ovary Syndrome correlates with hyperandrogenism. J Clin Endocrinol Metab. 2018;103(4):1502–11. https://doi.org/10.1210/jc.2017-02153.
Article PubMed PubMed Central Google Scholar
Qi X, Yun C, Sun L, Xia J, Wu Q, Wang Y, et al. Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. Nat Med. 2019;25(8):1225–33. https://doi.org/10.1038/s41591-019-0509-0.
Article CAS PubMed PubMed Central Google Scholar
Yin G, Chen F, Chen G, Yang X, Huang Q, Chen L, et al. Alterations of bacteriome, mycobiome and metabolome characteristics in PCOS patients with normal/overweight individuals. J Ovarian Res. 2022;15(1):117. https://doi.org/10.1186/s13048-022-01051-8.
Article CAS PubMed PubMed Central Google Scholar
Rodriguez Paris V, Wong XYD, Solon-Biet SM, Edwards MC, Aflatounian A, Gilchrist RB, et al. The interplay between PCOS pathology and diet on gut microbiota in a mouse model. Gut Microbes. 2022;14(1):2085961. https://doi.org/10.1080/19490976.2022.2085961.
Article CAS PubMed PubMed Central Google Scholar
Graham ME, Herbert WG, Song SD, Raman HN, Zhu JE, Gonzalez PE, et al. Gut and vaginal microbiomes on steroids: implications for women’s health. Trends Endocrinol Metab. 2021;32(8):554–65. https://doi.org/10.1016/j.tem.2021.04.014.
Article CAS PubMed PubMed Central Google Scholar
Han Q, Wang J, Li W, Chen ZJ, Du Y. Androgen-induced gut dysbiosis disrupts glucolipid metabolism and endocrinal functions in polycystic ovary syndrome. Microbiome. 2021;9(1):101. https://doi.org/10.1186/s40168-021-01046-5.
Article CAS PubMed PubMed Central Google Scholar
Gupta A, Khanna S, Fecal Microbiota Transplantation. JAMA. 2017;318(1):102. https://doi.org/10.1001/jama.2017.6466.
Zhang F, Cui B, He X, Nie Y, Wu K, Fan D. Microbiota transplantation: concept, methodology and strategy for its modernization. Protein Cell. 2018;9(5):462–73. https://doi.org/10.1007/s13238-018-0541-8.
Article PubMed PubMed Central Google Scholar
Lundberg R, Toft MF, August B, Hansen AK, Hansen CH. Antibiotic-treated versus germ-free rodents for microbiota transplantation studies. Gut Microbes. 2016;7(1):68–74. https://doi.org/10.1080/19490976.2015.1127463.
Article PubMed PubMed Central Google Scholar
Han D, Walsh MC, Kim KS, Hong SW, Lee J, Yi J, et al. Microbiota-Independent Ameliorative effects of antibiotics on spontaneous Th2-Associated Pathology of the small intestine. PLoS ONE. 2015;10(2):e0118795. https://doi.org/10.1371/journal.pone.0118795.
Article CAS PubMed PubMed Central Google Scholar
Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, et al. Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. 2013;38(6):1211–22. https://doi.org/10.1016/j.immuni.2013.05.012.
Article CAS PubMed PubMed Central Google Scholar
Li J, Wei H. Establishment of an efficient germ-free animal system to support functional microbiome research. Sci China Life Sci. 2019;62(10):1400–3. https://doi.org/10.1007/s11427-019-9832-9.
Huang F, Chen J, Zhou M, Tang R, Xu S, Zhao Y, et al. Dysbiosis of the oral-gut microbiome in PCOS patients and its implication for noninvasive diagnosis. Clin Transl Med. 2024;14(8):e70001. https://doi.org/10.1002/ctm2.70001.
Article CAS PubMed PubMed Central Google Scholar
Revised. 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human reproduction (Oxford, England). 2004;19(1):41 – 7; https://doi.org/10.1093/humrep/deh098
McInnes P, Cutting M. Core microbiome sampling protocol A HMP Protocol # 07–001. 2010.
Yuan X, Wang R, Han B, Sun C, Chen R, Wei H, et al. Functional and metabolic alterations of gut microbiota in children with new-onset type 1 diabetes. Nat Commun. 2022;13(1):6356. https://doi.org/10.1038/s41467-022-33656-4.
Article CAS PubMed PubMed Central Google Scholar
Boehme M, Guzzetta KE, Bastiaanssen TFS, van de Wouw M, Moloney GM, Gual-Grau A, et al. Microbiota from young mice counteracts selective age-associated behavioral deficits. Nat Aging. 2021;1(8):666–76. https://doi.org/10.1038/s43587-021-00093-9.
Comments (0)