Purkinje Cell Dendritic Swellings: A Postmortem Study of Essential Tremor and Other Cerebellar Degenerative Disorders

Grady MS, McLaughlin MR, Christman CW, Valadka AB, Fligner CL, Povlishock JT. The use of antibodies targeted against the neurofilament subunits for the detection of diffuse axonal injury in humans. J Neuropathol Exp Neurol. 1993;52(2):143–52.

Article  CAS  PubMed  Google Scholar 

Hasbani MJ, Schlief ML, Fisher DA, Goldberg MP. Dendritic spines lost during glutamate receptor activation reemerge at original sites of synaptic contact. J Neurosci. 2001;21(7):2393–403.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossi F, Borsello T, Strata P. Exposure to kainic acid mimics the effects of axotomy in cerebellar Purkinje cells of the adult rat. Eur J Neurosci. 1994;6(3):392–402.

Article  CAS  PubMed  Google Scholar 

Corbo M, Hays AP. Peripherin and neurofilament protein coexist in spinal spheroids of motor neuron disease. J Neuropathol Exp Neurol. 1992;51(5):531–7.

Article  CAS  PubMed  Google Scholar 

Louis ED, Faust PL, Vonsattel JP, Honig LS, Rajput A, Rajput A, Pahwa R, Lyons KE, Ross WG, Elble RJ, Erickson-Davis C, Moskowitz CB, Lawton A. Torpedoes in Parkinson’s disease, Alzheimer’s disease, essential tremor, and control brains. Mov Disord. 2009;24(11):1600–5.

Article  PubMed  PubMed Central  Google Scholar 

Yu M, Ma K, Faust PL, Honig LS, Cortés E, Vonsattel JP, Louis ED. Increased number of Purkinje cell dendritic swellings in essential tremor. Eur J Neurol. 2012;19(4):625–30.

Article  CAS  PubMed  Google Scholar 

Louis ED, Yi H, Erickson-Davis C, Vonsattel JP, Faust PL. Structural study of Purkinje cell axonal torpedoes in essential tremor. Neurosci Lett. 2009;450(3):287–91.

Article  CAS  PubMed  Google Scholar 

Petito CK, Hart MN, Porro RS, Earle KM. Ultrastructural studies of olivopontocerebellar atrophy. J Neuropathol Exp Neurol. 1973;32(4):503–22.

Article  CAS  PubMed  Google Scholar 

Mizushima SOS. An ultrastructural observation of torpedoes in the human degenerative cerebellum. J Clin Electron Microscopy. 1976;9:672–73.

Google Scholar 

Louis ED, Kerridge CA, Chatterjee D, Martuscello RT, Diaz DT, Koeppen AH, Kuo SH, Vonsattel JG, Sims PA, Faust PL. Contextualizing the pathology in the essential tremor cerebellar cortex: a patholog-omics approach. Acta Neuropathol. 2019;138(5):859–76.

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Martuscello RT, Gionco JT, Hartstone WG, Musacchio JB, Portenti M, McCreary M, Kuo SH, Vonsattel JG, Faust PL. Histopathology of the cerebellar cortex in essential tremor and other neurodegenerative motor disorders: comparative analysis of 320 brains. Acta Neuropathol. 2023;145(3):265–83.

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Kuo SH, Tate WJ, Kelly GC, Gutierrez J, Cortes EP, Vonsattel JG, Faust PL. Heterotopic Purkinje Cells: a Comparative Postmortem Study of Essential Tremor and Spinocerebellar Ataxias 1, 2, 3, and 6. Cerebellum. 2018;17(2):104 – 10.

Babij R, Lee M, Cortes E, Vonsattel JP, Faust PL, Louis ED. Purkinje cell axonal anatomy: quantifying morphometric changes in essential tremor versus control brains. Brain. 2013;136(Pt 10):3051–61.

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Ottman R, Ford B, Pullman S, Martinez M, Fahn S, Hauser WA. The Washington heights-Inwood genetic study of essential tremor: methodologic issues in essential-tremor research. Neuroepidemiology. 1997;16(3):124–33.

Article  CAS  PubMed  Google Scholar 

Louis ED, Ford B, Bismuth B. Reliability between two observers using a protocol for diagnosing essential tremor. Mov Disord. 1998;13(2):287–93.

Article  CAS  PubMed  Google Scholar 

Louis ED, Wendt KJ, Albert SM, Pullman SL, Yu Q, Andrews H. Validity of a performance-based test of function in essential tremor. Arch Neurol. 1999;56(7):841–6.

Article  CAS  PubMed  Google Scholar 

Harasymiw JW, Bean P. Identification of heavy drinkers by using the early detection of alcohol consumption score. Alcohol Clin Exp Res. 2001;25(2):228–35.

Article  CAS  PubMed  Google Scholar 

Choe M, Cortes E, Vonsattel JP, Kuo SH, Faust PL, Louis ED. Purkinje cell loss in essential tremor: Random sampling quantification and nearest neighbor analysis. Mov Disord. 2016;31(3):393–401.

Article  PubMed  PubMed Central  Google Scholar 

Lee PJ, Kerridge CA, Chatterjee D, Koeppen AH, Faust PL, Louis ED. A quantitative study of empty baskets in essential tremor and other Motor Neurodegenerative diseases. J Neuropathol Exp Neurol. 2019;78(2):113–22.

Article  CAS  PubMed  Google Scholar 

Lin CY, Louis ED, Faust PL, Koeppen AH, Vonsattel JP, Kuo SH. Abnormal climbing fibre-purkinje cell synaptic connections in the essential tremor cerebellum. Brain. 2014;137(Pt 12):3149–59.

Article  PubMed  PubMed Central  Google Scholar 

Louis ED, Vonsattel JP, Honig LS, Ross GW, Lyons KE, Pahwa R. Neuropathologic findings in essential tremor. Neurology. 2006;66(11):1756–9.

Article  CAS  PubMed  Google Scholar 

Erickson-Davis CR, Faust PL, Vonsattel JP, Gupta S, Honig LS, Louis ED. Hairy baskets associated with degenerative Purkinje cell changes in essential tremor. J Neuropathol Exp Neurol. 2010;69(3):262–71.

Article  PubMed  Google Scholar 

Koeppen AH, Davis AN, Morral JA. The cerebellar component of Friedreich’s ataxia. Acta Neuropathol. 2011;122(3):323–30.

Article  PubMed  PubMed Central  Google Scholar 

Troost D, van Rossum A, Straks W, Willemse J. Menkes’ kinky hair disease. II. A clinicopathological report of three cases. Brain Dev. 1982;4(2):115–26.

Article  CAS  PubMed  Google Scholar 

Ferrer I, Cusi V, Pineda M, Galofre E, Vila J. Focal dendritic swellings in Purkinje cells in mucopolysaccharidoses types I, II and III. A golgi and ultrastructural study. Neuropathol Appl Neurobiol. 1988;14(4):315–23.

Article  CAS  PubMed  Google Scholar 

Doshi R, Sandry SA, Churchill AW, Brownell B. The cerebellum in mucopolysaccharidosis. A histological, histochemical, and ultrastructural study. J Neurol Neurosurg Psychiatry. 1974;37(10):1133–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldman JE, Katz D, Rapin I, Purpura DP, Suzuki K. Chronic GM1 gangliosidosis presenting as dystonia: I. Clinical and pathological features. Ann Neurol. 1981;9(5):465–75.

Article  CAS  PubMed  Google Scholar 

Mizutani T, Maeda S, Hayakawa K, Tanaka U, Hirahata S, Kamoshita H, Taketani T, Morimatsu Y. Paraneoplastic cortical cerebellar degeneration. A neuropathological study of an autopsy case in comparison with cortical cerebellar degeneration in alcoholics. Acta Neuropathol. 1988;77(2):206–12.

Article  CAS  PubMed  Google Scholar 

Yang Q, Hashizume Y, Yoshida M, Wang Y, Goto Y, Mitsuma N, Ishikawa K, Mizusawa H. Morphological Purkinje cell changes in spinocerebellar ataxia type 6. Acta Neuropathol. 2000;100(4):371–6.

Article  CAS  PubMed  Google Scholar 

Kato S, Hayashi H, Mikoshiba K, Hirano A, Yen SH, Ohama E. Purkinje cells in olivopontocerebellar atrophy and granule cell-type cerebellar degeneration: an immunohistochemical study. Acta Neuropathol. 1998;96(1):67–74.

Article  CAS  PubMed  Google Scholar 

Horoupian DS. Dystrophic’ Purkinje cell dendrites in an infant. Acta Neuropathol. 1982;57(2–3):165–70.

Article  CAS  PubMed  Google Scholar 

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