Protocol for a systematic review and meta-analysis of interventions aimed at delabeling low-risk penicillin allergies with consideration for sex and gender

Lipsky BA, Baker PD, Landon GC, Fernau R. Antibiotic therapy for diabetic foot infections: comparison of two parenteral-to-oral regimens. Clin Infect Dis Off Publ Infect Dis Soc Am. 1997;24(4):643–8.

Article  CAS  Google Scholar 

Kish TD, Chang MH, Fung HB. Treatment of skin and soft tissue infections in the elderly: a review. Am J Geriatr Pharmacother. 2010;8(6):485–513.

Article  PubMed  Google Scholar 

Lipsky BA, Itani K, Norden C. Treating foot infections in diabetic patients: a randomized, multicenter, open-label trial of linezolid versus ampicillin-sulbactam/amoxicillin-clavulanate. Clin Infect Dis Off Publ Infect Dis Soc Am. 2004;38(1):17–24.

Article  CAS  Google Scholar 

Brambilla C, Kastanakis S, Knight S, Cunningham K. Cefuroxime and cefuroxime axetil versus amoxicillin plus clavulanic acid in the treatment of lower respiratory tract infections. Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol. 1992;11(2):118–24.

Article  CAS  Google Scholar 

Jeimy S, Ben-Shoshan M, Abrams EM, Ellis AK, Connors L, Wong T. Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology. Allergy Asthma Clin Immunol Off J Can Soc Allergy Clin Immunol. 2020;16(1):95–95.

Article  Google Scholar 

Blumenthal KG, Shenoy ES, Varughese CA, Hurwitz S, Hooper DC, Banerji A. Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy. Ann Allergy Asthma Immunol Off Publ Am Coll Allergy Asthma Immunol. 2015;115(4):294–300.e2.

Article  Google Scholar 

Stevenson B, Trevenen M, Klinken E, Smith W, Yuson C, Katelaris C, et al. Multicenter Australian study to determine criteria for low- and high-risk penicillin testing in outpatients. J Allergy Clin Immunol Pract. 2020;8(2):681–689.e3.

Article  PubMed  Google Scholar 

Sousa-Pinto B, Tarrio I, Blumenthal KG, Araújo L, Azevedo LF, Delgado L, et al. Accuracy of penicillin allergy diagnostic tests: a systematic review and meta-analysis. J Allergy Clin Immunol. 2021;147(1):296–308.

Article  PubMed  CAS  Google Scholar 

Stone C, Vanderbilt University Medical Center. The effect of providing stratification of low risk penicillin allergies on penicillin allergy label removal. Clinicaltrials.gov. 2018; Available from: https://clinicaltrials.gov/ct2/show/NCT03702270.

Brabete AC, Greaves L, Maximos M, Huber E, Li A, Lê ML. A sex- and gender-based analysis of adverse drug reactions: a scoping review of pharmacovigilance databases. Pharmaceuticals. 2022;15(3):298.

Article  PubMed  PubMed Central  Google Scholar 

Park MA, Matesic D, Markus PJ, Li JTC. Female sex as a risk factor for penicillin allergy. Ann Allergy Asthma Immunol. 2007;99(1):54–8.

Article  PubMed  Google Scholar 

Voelker DH, Gonzalez-Estrada A, Park MA. Female sex as a risk factor for penicillin drug allergy in the inpatient setting. Allergy Asthma Proc. 2022;43(2):163–7.

Article  PubMed  CAS  Google Scholar 

Fox SJ, Park MA. Female sex is not a risk factor for penicillin allergy in the pediatric population. J Allergy Clin Immunol. 2011;127(2):AB251–AB251.

Article  Google Scholar 

Whitley HP, Lindsey W. Sex-based differences in drug activity. Am Fam Physician. 2009;80(11):1254–8.

PubMed  Google Scholar 

De Martinis M, Sirufo MM, Suppa M, Di Silvestre D, Ginaldi L. Sex and gender aspects for patient stratification in allergy prevention and treatment. Int J Mol Sci. 2020;21(4):1535.

Article  PubMed  PubMed Central  Google Scholar 

Salvati L, Vitiello G, Parronchi P. Gender differences in anaphylaxis. Curr Opin Allergy Clin Immunol. 2019;19(5):417–24.

Article  PubMed  CAS  Google Scholar 

Higgins JPT TJ Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane handbook for systematic reviews of interventions. Version 6. 2021. Available from: https://www.training.cochrane.org/handbook.

Centre for Reviews and Dissemination. CRD’s Guidance for Undertaking Reviews in HealthCare. Available from: https://www.york.ac.uk/crd/SysRev/!SSL!/WebHelp/TITLEPAGE.htm. Cited 2022 Aug 15.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. 2009;62(10):e1–34.

Article  PubMed  Google Scholar 

Slattery P, Saeri AK, Bragge P. Research co-design in health: a rapid overview of reviews. Health Res Policy Syst. 2020;18(1):1–13.

Article  Google Scholar 

Loprete J, Beiglari L, O’Neill R, Li T, Carr A, Comben S, et al. An evidence-based approach to penicillin allergy testing and de-labelling: a systematic review PROSPERO protocol. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=140266. Cited 2022 Aug 15.

Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaborations tool for assessing risk of bias in randomised trials. BMJ. 2011;343. Available from: https://www.bmj.com/content/343/bmj.d5928.

Chapter 25: Assessing risk of bias in a non-randomized study | Cochrane Training. Available from: https://training.cochrane.org/handbook/current/chapter-25.

O’Neill J, Tabish H, Welch V, Petticrew M, Pottie K, Clarke M, et al. Applying an equity lens to interventions: using PROGRESS ensures consideration of socially stratifying factors to illuminate inequities in health. J Clin Epidemiol. 2014;67(1):56–64.

Article  PubMed  Google Scholar 

Covidence systematic review software. Melbourne, Australia; Available from: https://www.covidence.org.

Cornell JE, Mulrow CD, Localio R, Stack CB, Meibohm AR, Guallar E, et al. Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med. 2014;160(4):267–70.

Article  PubMed  Google Scholar 

Barker TH, Migliavaca CB, Stein C, Colpani V, Falavigna M, Aromataris E, et al. Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence. BMC Med Res Methodol. 2021;21(1):189.

Article  PubMed  PubMed Central  Google Scholar 

Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21(11):1539–58.

Article  PubMed  Google Scholar 

Columbia University Mailman School of Public Health. 2016. Meta-Regression. Available from: https://www.publichealth.columbia.edu/research/population-health-methods/meta-regression. Cited 2023 Aug 16.

Sterne JAC, Egger M, Smith GD. Investigating and dealing with publication and other biases in meta-analysis. BMJ. 2001;323(7304):101–5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Stone CA, Stollings JL, Lindsell CJ, Dear ML, Buie RB, Rice TW, et al. Risk-stratified management to remove low-risk penicillin allergy labels in the ICU. Am J Respir Crit Care Med. 2020;201(12):1572–5.

Article  PubMed  PubMed Central  Google Scholar 

Kuruvilla M, Shih J, Patel K, Scanlon N. Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy. Allergy Asthma Proc. 2019;40(1):57–61.

Article  PubMed  Google Scholar 

Iammatteo M, Alvarez Arango S, Ferastraoaru D, Akbar N, Lee AY, Cohen HW, et al. Safety and outcomes of oral graded challenges to amoxicillin without prior skin testing. J Allergy Clin Immunol Pract. 2019;7(1):236–43.

Article  PubMed  Google Scholar 

Cooper L, Harbour J, Sneddon J, Seaton RA. Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge: a systematic review. JAC-Antimicrob Resist. 2021;3(1):dlaa123.

Article  PubMed  PubMed Central  Google Scholar 

Agarwal G, Awasthi S, Kabra SK, Kaul A, Singhi S, Walter SD, et al. Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children: a multicentre randomised controlled trial. BMJ. 2004;328(7443):791.

Article  PubMed  Google Scholar 

Raad I, Hachem R, Hanna H, Abi-Said D, Bivins C, Walsh G, et al. Treatment of nosocomial postoperative pneumonia in cancer patients: a prospective randomized study. Ann Surg Oncol. 2001;8(2):179–86.

Article  PubMed  CAS  Google Scholar 

Ricart E, Soriano G, Novella MT, Ortiz J, Sàbat M, Kolle L, et al. Amoxicillin-clavulanic acid versus cefotaxime in the therapy of bacterial infections in cirrhotic patients. J Hepatol. 2000;32(4):596–602.

Article  PubMed  CAS  Google Scholar 

Landholt TF, Kotschwar TR. A pharmacoeconomic comparison of amoxicillin/clavulanate and cefpodoxime proxetil in the treatment of acute otitis media. Clin Ther. 1994;16(2):327–33 discussion 271–272.

PubMed  CAS  Google Scholar 

Pelc A, Portier H, Gehanno P, Fiessinger S, Ichou F. Cost saving of 5-day therapy with cefpodoxime proxetil versus standard 10-day beta-lactam therapy for recurrent pharyngotonsillitis in adults. A prospective general practice study. PharmacoEconomics. 1996;10(3):239–50.

Article  PubMed  CAS 

Comments (0)

No login
gif