Goeppert B, Frauenschuh L, Zucknick M, et al. Prognostic impact of tumour-infiltrating immune cells on biliary tract cancer. Br J Cancer. 2013;109(10):2665–74. https://doi.org/10.1038/bjc.2013.610.
Article CAS PubMed PubMed Central Google Scholar
Oh DY, He AR, Qin S, et al. A phase 3 randomized, double-blind, placebo-controlled study of durvalumab in combination with gemcitabine plus cisplatin (GemCis) in patients (pts) with advanced biliary tract cancer (BTC): TOPAZ-1. J Clin Oncol. 2022;40(4):378. https://doi.org/10.1200/JCO.2022.40.4_suppl.378.
Ricci AD, Rizzo A, Brandi G. The DNA damage repair (DDR) pathway in biliary tract cancer (BTC): a new Pandora’s box? ESMO Open. 2020;5(5):e001042. https://doi.org/10.1136/esmoopen-2020-001042.
Article PubMed PubMed Central Google Scholar
Sahin TK, Rizzo A, Aksoy S, et al. Prognostic significance of the Royal Marsden Hospital (RMH) Score in patients with cancer: a systematic review and meta-analysis. Cancers (Basel). 2024;16(10):1835. https://doi.org/10.3390/cancers16101835.
Article CAS PubMed Google Scholar
Guven DG, Erul E, Kaygusuz Y, et al. Immune checkpoint inhibitor-related hearing loss: a systematic review and analysis of individual patient data. Support Care Cancer. 2023;31(12):624. https://doi.org/10.1007/s00520-023-08083-w.
Rizzo A, Mollica V, Tateo V, et al. Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study. Cancer Immunol Immunother. 2023;72(6):1381–94. https://doi.org/10.1007/s00262-023-03366-x.
Article PubMed PubMed Central Google Scholar
Rizzo A, Santoni M, Mollica V, et al. Peripheral neuropathy and headache in cancer patients treated with immunotherapy and immuno-oncology combinations: the MOUSEION-02 study. Expert Opin Drug Metab Toxicol. 2021;17(12):1455–66. https://doi.org/10.1080/17425255.2021.2029405.
Article CAS PubMed Google Scholar
Abou-Alfa GK, Sahai V, Hollebecque A, et al. Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study. Lancet Oncol. 2020;21(5):671–84. https://doi.org/10.1016/S1470-2045(20)30109-1.
Article CAS PubMed PubMed Central Google Scholar
Abou-Alfa GK, Macarulla T, Javle MM, et al. Ivosidenib in IDH1-mutant, chemotherapy-refractory cholangiocarcinoma (ClarIDHy): a multicentre, randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol. 2020;21(6):796–807. https://doi.org/10.1016/S1470-2045(20)30157-1.
Article CAS PubMed PubMed Central Google Scholar
Marabelle A, Le DT, Ascierto PA, et al. Efficacy of pembrolizumab in patients with noncolorectal high microsatellite instability/mismatch repair-deficient cancer: results from the phase II KEYNOTE-158 study. J Clin Oncol. 2020;38(1):1–10. https://doi.org/10.1200/JCO.19.02105.
Article CAS PubMed Google Scholar
Marabelle A, Fakih M, Lopez J, et al. Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study. Lancet Oncol. 2020;21(10):1353–65. https://doi.org/10.1016/S1470-2045(20)30445-9.
Article CAS PubMed Google Scholar
Kelley RK, Ueno M, Yoo C, et al. Pembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;401(10391):1853–65. https://doi.org/10.1016/S0140-6736(23)00727-4.
Mody K, Jain P, El-Refai SM, et al. Clinical, genomic, and transcriptomic data profiling of biliary tract cancer reveals subtype-specific immune signatures. JCO Precis Oncol. 2022;6: e2100510. https://doi.org/10.1200/PO.21.00510.
Article PubMed PubMed Central Google Scholar
Graham RP, Barr Fritcher EG, Pestova E, et al. Fibroblast growth factor receptor 2 translocations in intrahepatic cholangiocarcinoma. Hum Pathol. 2014;45(8):1630–8. https://doi.org/10.1016/j.humpath.2014.03.014.
Article CAS PubMed Google Scholar
Büttner R, Longshore JW, López-Ríos F, et al. Implementing TMB measurement in clinical practice: considerations on assay requirements. ESMO Open. 2019;4(1): e000442. https://doi.org/10.1136/esmoopen-2018-000442.
Article PubMed PubMed Central Google Scholar
Chalmers ZR, Connelly CF, Fabrizio D, et al. Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden. Genome Med. 2017;9(1):34. https://doi.org/10.1186/s13073-017-0424-2.
Article CAS PubMed PubMed Central Google Scholar
Mody K, Starr J, Saul M, et al. Patterns and genomic correlates of PD-L1 expression in patients with biliary tract cancers. J Gastrointest Oncol. 2019;10(6):1099–109. https://doi.org/10.21037/jgo.2019.08.08.
Article PubMed PubMed Central Google Scholar
Yarchoan M, Hopkins A, Jaffee EM. Tumor mutational burden and response rate to PD-1 inhibition. N Engl J Med. 2017;377(25):2500–1. https://doi.org/10.1056/NEJMc1713444.
Article PubMed PubMed Central Google Scholar
Valle JW, Lamarca A, Goyal L, et al. New horizons for precision medicine in biliary tract cancers. Cancer Discov. 2017;7(9):943–62. https://doi.org/10.1158/2159-8290.CD-17-0245.
Article CAS PubMed PubMed Central Google Scholar
Javle M, Borad MJ, Azad NS, et al. Pertuzumab and trastuzumab for HER2-positive, metastatic biliary tract cancer (MyPathway): a multicentre, open-label, phase 2a, multiple basket study. Lancet Oncol. 2021;22(9):1290–300. https://doi.org/10.1016/S1470-2045(21)00336-3.
Article CAS PubMed Google Scholar
Savas P, Salgado R, Denkert C, et al. Clinical relevance of host immunity in breast cancer: from TILs to the clinic. Nat Rev Clin Oncol. 2016;13(4):228–41. https://doi.org/10.1038/nrclinonc.2015.215.
Article CAS PubMed Google Scholar
Cimino-Mathews A, Thompson E, Taube JM, et al. PD-L1 (B7–H1) expression and the immune tumor microenvironment in primary and metastatic breast carcinomas. Hum Pathol. 2016;47(1):52–63. https://doi.org/10.1016/j.humpath.2015.09.003.
Article CAS PubMed Google Scholar
Dirix LY, Takacs I, Jerusalem G, et al. Avelumab, an anti-PD-L1 antibody, in patients with locally advanced or metastatic breast cancer: a phase 1b JAVELIN Solid Tumor study. Breast Cancer Res Treat. 2018;167(3):671–86. https://doi.org/10.1007/s10549-017-4537-5.
Article CAS PubMed Google Scholar
DeMatteo R, Goldman DA, Lin ST, et al. Clinical outcomes of immune checkpoint inhibitors in HER2-amplified non-small cell lung cancers. J Clin Oncol. 2022;40(16):21098. https://doi.org/10.1200/JCO.2022.40.16_suppl.e21098.
Loi S, Giobbie-Hurder A, Gombos A, et al. Pembrolizumab plus trastuzumab in trastuzumab-resistant, advanced, HER2-positive breast cancer (PANACEA): a single-arm, multicentre, phase 1b–2 trial. Lancet Oncol. 2019;20(3):371–82. https://doi.org/10.1016/S1470-2045(18)30812-X.
Article CAS PubMed Google Scholar
Janjigian YY, Kawazoe A, Yañez P, et al. The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer. Nature. 2021;600(7890):727–30. https://doi.org/10.1038/s41586-021-04161-3.
Article CAS PubMed PubMed Central Google Scholar
Zhang JW, Yang X, Pan B, et al. Clinical response to adding pyrotinib to pembrolizumab and lenvatinib for HER2-positive advanced intrahepatic cholangiocarcinoma: a case report. World J Surg Oncol. 2023;21(1):108. https://doi.org/10.1186/s12957-023-02983-1.
Comments (0)