Brammer KW, Farrow PR, Faulkner JK. Pharmacokinetics and tissue penetration of fluconazole in humans. Clin Infect Dis. 1990;12:S318–26.

Article  Google Scholar 

Chaube S, Murphy ML. The teratogenic effects of 5-fluorocytosine in the rat. Cancer Res. 1969;29(3):554–7.

CAS  PubMed  Google Scholar 

Menegola E, Broccia ML, Di Renzo F, Giavini E. Pathogenic pathways in fluconazole-induced branchial arch malformations. Birth Defects Res A. 2003;67:116–24.

Article  CAS  Google Scholar 

Lopez-Rangel E, Van Allen MI. Prenatal exposure to fluconazole: an identifiable dysmorphic phenotype. Birth Defects Res A Clin Mol Teratol. 2005;73:919–23.

Article  CAS  PubMed  Google Scholar 

Lee BE, Feinberg M, Abraham JJ, Murthy AR. Congenital malformations in an infant born to a woman treated with fluconazole. Pediatr Infect Dis J. 1992;11:1062–4.

Article  CAS  PubMed  Google Scholar 

Aleck KA, Bartley DL. Multiple malformation syndrome following fluconazole use in pregnancy: report of an additional patient. Am J Med Genet. 1997;72:253–6.

Article  CAS  PubMed  Google Scholar 

Pursley TJ, Blomquist IK, Abraham J, Andersen HF, Bartley JA. Fluconazole-induced congenital anomalies in three infants. Clin Infect Dis. 1996;22:336–40.

Article  CAS  PubMed  Google Scholar 

Zhu Y, Bateman BT, Gray KJ, Hernandez-Diaz S, Mogun H, Straub L, et al. Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study. BMJ. 2020;369: m1494.

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Li L, Lv Q, Yan L, Wang Y, Jiang Y. The fungal CYP51s: their functions, structures, related drug resistance, and inhibitors. Front Microbiol. 2019;10:691.

Article  PubMed  PubMed Central  Google Scholar 

Alsaad AMS, Kaplan YC, Koren G. Exposure to fluconazole and risk of congenital malformations in the offspring: a systematic review and meta-analysis. Reprod Toxicol. 2015;52:78–82.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Zhang X, Zhou Y-Y, Jiang C-M, Jiang H-Y. The safety of oral fluconazole during the first trimester of pregnancy: a systematic review and meta-analysis. BJOG. 2019;126:1546–52.

Article  CAS  PubMed  Google Scholar 

Liu D, Zhang C, Wu L, Zhang L, Zhang L. Fetal outcomes after maternal exposure to oral antifungal agents during pregnancy: a systematic review and meta-analysis. Int J Gynaecol Obstet. 2020;148:6–13.

Article  PubMed  Google Scholar 

Marin B, Vauzelle C, Coulm B, Beghin D, Latour M, Tubach F, et al. Comment on “maternal use of fluconazole and congenital malformations in the progeny: a meta-analysis of the literature.” Reprod Toxicol. 2021;104:168.

Article  CAS  PubMed  Google Scholar 

Budani MC, Fensore S, Di Marzio M, Tiboni GM. Maternal use of fluconazole and congenital malformations in the progeny: a meta-analysis of the literature. Reprod Toxicol. 2021;100:42–51.

Article  CAS  PubMed  Google Scholar 

Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane handbook for systematic reviews of interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from: www.training.cochrane.org/handbook.

Moher D, Liberati A, Tetzlaff J, Altman D, Group The PRISMA. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. [Internet]. PLoS Med; 2009. Available from: https://doi.org/10.1371/journal.pmed.1000097.

Stroup DF. Meta-analysis of observational studies in epidemiology a proposal for reporting. JAMA. 2000;283:2008.

Article  CAS  PubMed  Google Scholar 

Latour M, Vauzelle C, Elefant E, Dechartres A, Marin B, Tubach F. Risk of congenital malformation following maternal use of oral fluconazole (low dose/high dose) during the first trimester of pregnancy: a systematic review and meta-analysis. PROSPERO 2021 CRD42021274003 Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021274003.

Gordis L. Epidemiology. 4th ed. Amsterdam: Elsevier; 2009.

Google Scholar 

EUROCAT. EUROCAT Guide 1.5: instruction for the registration of congenital anomalies. EUROCAT central registry, University of Ulster; 2022.

Lefebvre C, Glanville J, Briscoe S, Featherstone R, Littlewood A, Metzendorf M-I, Noel-Storr A, Paynter R, Rader T, Thomas J, Wieland LS. Chapter 4: Searching for and selecting studies. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated October 2023). Cochrane, 2023. Available from www.training.cochrane.org/handbook.

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. The risk of bias in non-randomized studies–of interventions (ROBINS-I) assessment tool.

Bérard A, Sheehy O, Zhao J-P, Gorgui J, Bernatsky S, de Moura CS, et al. Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies. CMAJ. 2019;191:E179–87.

Article  PubMed  PubMed Central  Google Scholar 

Mølgaard-Nielsen D, Pasternak B, Hviid A. Use of oral fluconazole during pregnancy and the risk of birth defects. N Engl J Med. 2013;369:830–9.

Article  PubMed  Google Scholar 

Sedgwick P. Relative risks versus odds ratios. BMJ. 2014;348: g1407.

Article  Google Scholar 

George A, Stead TS, Ganti L. What’s the risk: differentiating risk ratios, odds ratios, and hazard ratios? Cureus [Internet]. 2020 [cited 2024 May 27]; Available from: https://www.cureus.com/articles/39455-whats-the-risk-differentiating-risk-ratios-odds-ratios-and-hazard-ratios.

VanderWeele TJ. Optimal approximate conversions of odds ratios and hazard ratios to risk ratios. Biometrics. 2020;76:746–52.

Article  PubMed  Google Scholar 

Borenstein M, Hedges L, Higgins J, Rothstein H. Introduction to Meta-analysis. Chichester: John Wiley & Sons; 2008.

Google Scholar 

Higgins JPT, Eldridge S, Li T (editors). Chapter 23: Including variants on randomized trials. Section 23.3.4: How to include multiple groups from one study. In: Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA, editors. Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane, 2022. Available from www.training.cochrane.org/handbook.

Core Team. R: A language and environment for statistical computing. [Internet]. Vienna, Austria: R Foundation for Statistical Computing; 2023. Available from: https://www.R-project.org/.

Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336:924–6.

Article  PubMed  PubMed Central  Google Scholar 

McMaster University and Evidence Prime. GRADEpro GDT: GRADEpro Guideline Development Tool. [Internet]. 2022. Available from: gradepro.org.

Howley MM, Carter TC, Browne ML, Romitti PA, Cunniff CM, Druschel CM, et al. Fluconazole use and birth defects in the National Birth Defects Prevention Study. Am J Obstet Gynecol. 2016;214(657):e1-9.

Google Scholar 

Jick SS. Pregnancy outcomes after maternal exposure to fluconazole. Pharmacotherapy. 1999;19:221–2.

Article  CAS  PubMed  Google Scholar 

Mastroiacovo P, Mazzone T, Botto LD, Serafini MA, Finardi A, Caramelli L, et al. Prospective assessment of pregnancy outcomes after first-trimester exposure to fluconazole. Am J Obstet Gynecol. 1996;175:1645–50.

Article  CAS  PubMed  Google Scholar 

Dormuth C, Winquist B, Fisher A, Wu F, Reynier P, Dahl M, et al. Use of oral fluconazole during pregnancy and risks of spontaneous abortion, stillbirth and major congenital malformation: an international, multi-centre cohort study. Pharmacoepidemiol Drug Saf. 2019;28:14.

Google Scholar 

Mølgaard-Nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B. Association between use of oral fluconazole during pregnancy and risk of spontaneous abortion and stillbirth. JAMA. 2016;315:58–67.

Article  PubMed  Google Scholar 

Sorensen HT, Nielsen GL, Olesen C, Larsen H, Steffensen FH, Schønheyder HC, et al. Risk of malformations and other outcomes in children exposed to fluconazole in utero. Br J Clin Pharmacol. 1999;48:234–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

The European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) Guide on Methodological Standards in Pharmacoepidemiology. Annex 2. Guidance on methods for the evaluation of medicines in pregnancy and breastfeeding. Chapter 4. Measuring maternal, pregnancy, and neonatal outcomes. Section 4.2. Safety outcomes. https://www.encepp.eu/standards_and_guidances/methodologicalGuideAnnex2.shtml#nine [accessed on 02.06.2024].

Nørgaard M, Pedersen L, Gislum M, Erichsen R, Søgaard KK, Schønheyder HC, et al. Maternal use of fluconazole and risk of congenital malformations: a Danish population-based cohort study. J Antimicrob Chemother. 2008;62:172–6.

Article  PubMed  Google Scholar