B.A. Drew, M.E. Burow, B.S. Beckman, MEK5/ERK5 pathway: the first fifteen years. Biochim. Biophys. Acta. 1825(1), 37–48 (2012)

CAS  PubMed  Google Scholar 

B. Stecca, E. Rovida, Impact of ERK5 on the hallmarks of Cancer. Int. J. Mol. Sci. 20(6), 1426 (2019)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Z. Lombardi, L. Gardini, A.V. Kashchuk, A. Menconi, M. Lulli, I. Tusa, A. Tubita, L. Maresca, B. Stecca, M. Capitanio, E. Rovida, Importin subunit beta-1 mediates ERK5 nuclear translocation, and its Inhibition synergizes with ERK5 kinase inhibitors in reducing cancer cell proliferation. Mol. Oncol. 4 (2024)

N. Gomez, T. Erazo, J.M. Lizcano, ERK5 and cell proliferation: nuclear localization is what matters. Front. Cell. Dev. Biol. 4, 105 (2016)

Article  PubMed  PubMed Central  Google Scholar 

A. Tubita, Z. Lombardi, I. Tusa, P. Dello Sbarba, E. Rovida, Beyond kinase activity: ERK5 Nucleo-Cytoplasmic shuttling as a novel target for anticancer therapy. Int. J. Mol. Sci. 21(3), 938 (2020)

Article  CAS  PubMed  PubMed Central  Google Scholar 

P.W. Ingham, A.P. McMahon, Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15(23), 3059–3087 (2001)

Article  CAS  PubMed  Google Scholar 

N.M. Nguyen, J. Cho, Hedgehog pathway inhibitors as targeted Cancer therapy and strategies to overcome drug resistance. Int. J. Mol. Sci. 23(3), 1733 (2022)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Pietrobono, E. Gaudio, S. Gagliardi, M. Zitani, L. Carrassa, F. Migliorini, E. Petricci, F. Manetti, N. Makukhin, A.G. Bond, B.D. Paradise, A. Ciulli, M.E. Fernandez-Zapico, F. Bertoni, B. Stecca, Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway Inhibition in melanoma. Oncogene. 40(22), 3799–3814 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

F. Wu, Y. Zhang, B. Sun, A.P. McMahon, Y. Wang, Hedgehog signaling: from basic biology to Cancer therapy. Cell. Chem. Biol. 24(3), 252–280 (2017)

Article  CAS  PubMed  PubMed Central  Google Scholar 

E. Rovida, B. Stecca, Mitogen-activated protein kinases and Hedgehog-GLI signaling in cancer: A crosstalk providing therapeutic opportunities? Semin Cancer Biol. 35, 154–167 (2015)

Article  CAS  PubMed  Google Scholar 

B. Stecca, C. Mas, V. Clement, M. Zbinden, R. Correa, V. Piguet, F. Beermann, Ruiz i Altaba, melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc. Natl. Acad. Sci. U S A 104(14), 5895–5900 (2007)

Article  CAS  PubMed  PubMed Central  Google Scholar 

I. Tusa, S. Gagliardi, A. Tubita, S. Pandolfi, C. Urso, L. Borgognoni, J. Wang, X. Deng, N.S. Gray, B. Stecca, Rovida. ERK5 is activated by oncogenic BRAF and promotes melanoma growth. Oncogene. 37(19), 2601–2614 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

K.E. O’Reilly, E.V. de Miera, M.F. Segura, E. Friedman, L. Poliseno, S.W. Han, J. Zhong, J. Zavadil, A. Pavlick, E. Hernando, I. Osman, Hedgehog pathway Blockade inhibits melanoma cell growth in vitro and in vivo. Pharmaceuticals (Basel). 6(11), 1429–1450 (2013)

Article  PubMed  Google Scholar 

I. Tusa, S. Gagliardi, A. Tubita, S. Pandolfi, A. Menconi, M. Lulli, P. Dello Sbarba, B. Stecca, E. Rovida, The Hedgehog-GLI pathway regulates MEK5-ERK5 expression and activation in melanoma cells. Int. J. Mol. Sci. 22(20), 11259 (2021)

Article  CAS  PubMed  PubMed Central  Google Scholar 

S. Pandolfi, V. Montagnani, J.Y. Penachioni, M.C. Vinci, B. Olivito, L. Borgognoni, B. Stecca, WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function. Oncogene. 32(40), 4737–4747 (2013)

Article  CAS  PubMed  Google Scholar 

R. Santini, S. Pietrobono, S. Pandolfi, V. Montagnani, M. D’Amico, J.Y. Penachioni, M.C. Vinci, L. Borgognoni, B. Stecca, SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells. Oncogene. 33(38), 4697–4708 (2014)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J. Wang, T. Erazo, F.M. Ferguson, D.L. Buckley, N. Gomez, P. Muñoz-Guardiola, N. Diéguez-Martínez, X. Deng, M. Hao, W. Massefski, O. Fedorov, N.K. Offei-Addo, P.M. Park, L. Dai, A. DiBona, K. Becht, N.D. Kim, M.R. McKeown, J.M. Roberts, J. Zhang, T. Sim, D.R. Alessi, J.E. Bradner, J.M. Lizcano, S.C. Blacklow, J. Qi, X. Xu, Gray, structural and atropisomeric factors governing the selectivity of Pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains. ACS Chem. Biol. 13(9), 2438–2448 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

E.C. Lin, C.M. Amantea, T.K. Nomanbhoy, H. Weissig, J. Ishiyama, Y. Hu, S. Sidique, B. Li, J.W. Kozarich, J.S. Rosenblum, ERK5 kinase activity is dispensable for cellular immune response and proliferation. Proc. Natl. Acad. Sci. U S A 113(42), 11865–11870 (2016)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Q. Yang, X. Deng, B. Lu, M. Cameron, C. Fearns, M.P. Patricelli, J.R. 3 Yates, N.S. Gray, J.D. Lee, Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell. 18(3) (2010) 258–267. Erratum in: Cancer Cell. 2010 18(4) (2010) 396

A.V. Vaseva, D.R. Blake, T.S.K. Gilbert, S. Ng, G. Hostetter, S.H. Azam, I. Ozkan-Dagliyan, P. Gautam, K.L. Bryant, K.H. Pearce, L.E. Herring, H. Han, L.M. Graves, A.K. Witkiewicz, E.S. Knudsen, C.V. Pecot, N. Rashid, P.J. Houghton, K. Wennerberg, A.D. Cox, C.J. Der, KRAS Suppression-Induced degradation of MYC is antagonized by a MEK5-ERK5 compensatory mechanism. Cancer Cell. 34(5), 807–822e7 (2018)

Article  CAS  PubMed  PubMed Central  Google Scholar 

R.J. Tatake, M.M. O’Neill, C.A. Kennedy, A.L. Wayne, S. Jakes, D. Wu, S.Z. Jr Kugler, M.A. Kashem, P. Kaplita, R.J. Snow, Identification of Pharmacological inhibitors of the MEK5/ERK5 pathway. Biochem. Biophys. Res. Commun. 377(1), 120–125 (2008)

Article  CAS  PubMed  Google Scholar 

M. Lauth, A. Bergström, T. Shimokawa, R. Toftgård, Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc. Natl. Acad. Sci. U S A 104(20), 8455–8460 (2007)

Article  CAS  PubMed  PubMed Central  Google Scholar 

J.K. Chen, J. Taipale, K.E. Young, T. Maiti, P.A. Beachy, Small molecule modulation of smoothened activity. Proc. Natl. Acad. Sci. U S A 99(22), 14071–14076 (2002)

Article  CAS  PubMed  PubMed Central  Google Scholar 

V. Barbetti, A. Morandi, I. Tusa, G. Digiacomo, M. Riverso, I. Marzi, M.G. Cipolleschi, S. Bessi, A. Giannini, A. Di Leo, P. Dello Sbarba, E. Rovida, Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells. Oncogene. 33(34), 4359–4364 (2014)

Article  CAS  PubMed  Google Scholar 

E. Rovida, E. Spinelli, S. Sdelci, V. Barbetti, A. Morandi, S. Giuntoli, P. Dello Sbarba, ERK5/BMK1 is indispensable for optimal colony-stimulating factor 1 (CSF-1)-induced proliferation in macrophages in a Src-dependent fashion. J. Immunol. 180(6), 4166–4172 (2008)

Article  CAS  PubMed  Google Scholar 

G. Cheloni, M. Poteti, S. Bono, E. Masala, N.M. Mazure, E. Rovida, M. Lulli, Dello Sbarba, the leukemic stem cell niche: adaptation to hypoxia versus oncogene addiction. Stem Cells Int. 2017, 4979474 (2017)

Article  PubMed  PubMed Central  Google Scholar 

E. Rovida, G. Di Maira, I. Tusa, S. Cannito, C. Paternostro, N. Navari, E. Vivoli, X. Deng, N.S. Gray, A. Esparís-Ogando, E. David, A. Pandiella, P. Dello Sbarba, M. Parola, F. Marra, The mitogen-activated protein kinase ERK5 regulates the development and growth of hepatocellular carcinoma. Gut. 64(9), 1454–1465 (2015)

Article  CAS  PubMed  Google Scholar 

B. Stecca, A. Ruiz i Altaba, A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers. EMBO J. 28(6), 663–676 (2009)

Article  CAS  PubMed  PubMed Central  Google Scholar 

H. Sasaki, C. Hui, M. Nakafuku, H. Kondoh, A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development. 124(7), 1313–1322 (1997)

Article  CAS