Institute for Health Metrics and Evaluation (IHME). Global burden of disease 2021: findings from the GBD 2021 study [Internet]. Seattle, WA: IHME; 2024. Available from: https://www.healthdata.org/research-analysis/library/global-burden-disease-2021-findings-gbd-2021-study. Accessed 8 Jan 2025.

Hood L. A Personal View of Molecular Technology and How It Has Changed Biology. J Proteome Res. 2002;1(5):399–409.

Article  CAS  PubMed  Google Scholar 

Adler A, Novelli V, Amin AS, Abiusi E, Care M, Nannenberg EA, et al. An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome. Circulation. 2020;141(6):418–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Villard E, Perret C, Gary F, Proust C, Dilanian G, Hengstenberg C, et al. A Genome-Wide Association Study Identifies Two Loci Associated with Heart Failure Due to Dilated Cardiomyopathy. Eur Heart J. 2011;32(9):1065–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Levin MG, Tsao NL, Singhal P, Liu C, Vy HMT, Paranjpe I, et al. Genome-Wide Association and Multi-Trait Analyses Characterize the Common Genetic Architecture of Heart Failure. Nat Commun. 2022;13(1):6914.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyazawa K, Ito K, Ito M, Zou Z, Kubota M, Nomura S, et al. Cross-Ancestry Genome-Wide Analysis of Atrial Fibrillation Unveils Disease Biology and Enables Cardioembolic Risk Prediction. Nat Genet. 2023;55(2):187–97.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Law CW, Chen Y, Shi W, Smyth GK. Voom: Precision Weights Unlock Linear Model Analysis Tools for Rna-Seq Read Counts. Genome Biol. 2014;15(2):R29.

Article  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S. Moderated Estimation of Fold Change and Dispersion for Rna-Seq Data with DESeq2. Genome Biol. 2014;15(12):550.

Article  PubMed  PubMed Central  Google Scholar 

Hahn VS, Knutsdottir H, Luo X, Bedi K, Margulies KB, Haldar SM, et al. Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction. Circulation. 2021;143(2):120–34.

Article  CAS  PubMed  Google Scholar 

Verdonschot JAJ, Wang P, Derks KWJ, Adriaens ME, Stroeks SLVM, Henkens MTHM, et al. Clustering of Cardiac Transcriptome Profiles Reveals Unique: Subgroups of Dilated Cardiomyopathy Patients. JACCL Basic Trans Sci. 2023;8(4):406–18.

Google Scholar 

Liu Y, Beyer A, Aebersold R. On the Dependency of Cellular Protein Levels on mRNA Abundance. Cell. 2016;165(3):535–50.

Article  CAS  PubMed  Google Scholar 

Buccitelli C, Selbach M. mRNAs, Proteins and the Emerging Principles of Gene Expression Control. Nat Rev Genet. 2020;21(10):630–44.

Article  CAS  PubMed  Google Scholar 

Wang D, Eraslan B, Wieland T, Hallström B, Hopf T, Zolg DP, et al. A Deep Proteome and Transcriptome Abundance Atlas of 29 Healthy Human Tissues. Mol Syst Biol. 2019;15(2):e8503.

Article  PubMed  PubMed Central  Google Scholar 

Schwanhäusser B, Busse D, Li N, Dittmar G, Schuchhardt J, Wolf J, et al. Global Quantification of Mammalian Gene Expression Control. Nature. 2011;473(7347):337–42.

Article  PubMed  Google Scholar 

Doll S, Dreßen M, Geyer PE, Itzhak DN, Braun C, Doppler SA, et al. Region and Cell-Type Resolved Quantitative Proteomic Map of the Human Heart. Nat Commun. 2017;8(1):1469.

Article  PubMed  PubMed Central  Google Scholar 

Kahnert K, Soattin L, Mills RW, Wilson C, Maurya S, Sorrentino A, et al. Proteomics Couples Electrical Remodelling to Inflammation in a Murine Model of Heart Failure with Sinus Node Dysfunction. Cardiovasc Res. 2024;120(8):927–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pérez-Hernández M, van Opbergen CJM, Bagwan N, Vissing CR, Marrón-Liñares GM, Zhang M, et al. Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC. Circulation. 2022;146(11):851–67.

Article  PubMed  PubMed Central  Google Scholar 

Linscheid N, Santos A, Poulsen PC, Mills RW, Calloe K, Leurs U, et al. Quantitative Proteome Comparison of Human Hearts with Those of Model Organisms. PLoS Biol. 2021;19(4):e3001144.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Linscheid N, Poulsen PC, Pedersen ID, Gregers E, Svendsen JH, Olesen MS, et al. Quantitative Proteomics of Human Heart Samples Collected In Vivo Reveal the Remodeled Protein Landscape of Dilated Left Atrium Without Atrial Fibrillation. Mol Cell Proteomics. 2020;19(7):1132–44.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li M, Parker BL, Pearson E, Hunter B, Cao J, Koay YC, et al. Core Functional Nodes and Sex-Specific Pathways in Human Ischaemic and Dilated Cardiomyopathy. Nat Commun. 2020;11(1):2843.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kourelis TV, Dasari SS, Dispenzieri A, Maleszewski JJ, Redfield MM, Fayyaz AU, et al. A Proteomic Atlas of Cardiac Amyloid Plaques. JACC CardioOncol. 2020;2(4):632–43.

Article  PubMed  PubMed Central  Google Scholar 

Kim JC, Pérez-Hernández M, Alvarado FJ, Maurya SR, Montnach J, Yin Y, et al. Disruption of Ca2+i Homeostasis and Cx43 Hemichannel Function in the Right Ventricle Precedes Overt arrhythmogenic Cardiomyopathy in PKP2-Deficient Mice. Circulation. 2019;140(12):1015–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Phadke K, D’Anna S, Torres Vega E, Xiao J, Lin X, Zhang M, et al. Atrial cardiomyopathy resulting from loss of plakophilin-2 expression: response to adrenergic stimulation and implications for the exercise response. J Physiol. 2024. Available from: https://doi.org/10.1113/JP286985.

Sorrentino A, Bagwan N, Linscheid N, Poulsen PC, Kahnert K, Thomsen MB, et al. Beta-blocker/ACE Inhibitor Therapy Differentially Impacts the Steady State Signaling Landscape of Failing and Non-Failing Hearts. Sci Rep. 2022;12(1):4760.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Opbergen CJM, Bagwan N, Maurya SR, Kim JC, Smith AN, Blackwell DJ, et al. Exercise Causes Arrhythmogenic Remodeling of Intracellular Calcium Dynamics in Plakophilin-2–Deficient Hearts. Circulation. 2022;145(19):1480–96.

Article  PubMed  PubMed Central  Google Scholar 

Lundby A, Andersen MN, Steffensen AB, Horn H, Kelstrup CD, Francavilla C, et al. In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal. 2013;6(278):ra11.

Article  Google Scholar 

Achter JS, Vega ET, Sorrentino A, Kahnert K, Galsgaard KD, Hernandez-Varas P, et al. In-depth phosphoproteomic profiling of the insulin signaling response in heart tissue and cardiomyocytes unveils canonical and specialized regulation. Cardiovasc Diabetol. 2024;23(1):258.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maurya S, Mills RW, Kahnert K, Chiang DY, Bertoli G, Lundegaard PR, et al. Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram. Nat Cardiovasc Res. 2023;2(7):673–92.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Danese E, Montagnana M. An historical approach to the diagnostic biomarkers of acute coronary syndrome. Ann Transl Med. 2016;4(10):194.

Article  PubMed  PubMed Central  Google Scholar 

Geyer PE, Holdt LM, Teupser D, Mann M. Revisiting biomarker discovery by plasma proteomics. Mol Syst Biol. 2017;13(9):942.

Article  PubMed  PubMed Central  Google Scholar 

Sun BB, Chiou J, Traylor M, Benner C, Hsu YH, Richardson TG, et al. Genetic regulation of the human plasma proteome in 54,306 UK Biobank participants [Internet]. bioRxiv; 2022;2022.06.17.496443. https://doi.org/10.1101/2022.06.17.496443v1

Ioannidis JPA, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG. Replication validity of genetic a