Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM et al (2020) Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 76(25):2982–3021https://doi.org/10.1016/j.jacc.2020.11.010

Joglar JACMAA, Members PRC (2024) 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: a Report of the American College of Cardiology/ American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 149(1):e1-156.https://doi.org/10.1161/CIR.0000000000001193

Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP et al (2020) doi Heart Disease and Stroke Statistics-2020 Update: a Report From the American Heart Association. Circulation. 141(9):e139-596. https://doi.org/10.1161/CIR.0000000000000757

Gupta DK, Shah AM, Giugliano RP, Ruff CT, Antman EM, Grip LT et al (2014) Left atrial structure and function in atrial fibrillation: ENGAGE AF-TIMI 48. Eur Heart J 35(22):1457–1465. https://doi.org/10.1093/eurheartj/eht500

Article  Google Scholar 

Kotecha DLCVV (2016) Heart failure with preserved ejection Fraction and Atrial Fibrillation. J Am Coll Cardiol 68(20):2217–2228

Article  PubMed  Google Scholar 

Khan MSMMMM (2020) Left atrial function in heart failure with preserved ejection fraction: a systematic review and meta-analysis. Eur J Heart Fail 22(3):472–485. https://doi.org/10.1002/ejhf.1643

Article  PubMed  Google Scholar 

Santos ABS, Roca GQ, Claggett B, Sweitzer NK, Shah SJ, Anand IS et al (2016) Prognostic relevance of Left Atrial Dysfunction in Heart failure with preserved ejection fraction. Circulation: Heart Fail 9(4). https://doi.org/10.1161/CIRCHEARTFAILURE.115.002763

Santos ABS, Kraigher Krainer E, Gupta DK, Claggett B, Zile MR, Pieske B et al (2014) Impaired left atrial function in heart failure with preserved ejection fraction. Eur J Heart Fail 16(10):1096–1103. https://doi.org/10.1002/ejhf.147

Article  PubMed  CAS  Google Scholar 

January CTWLAJ, Guidelines ACOC (2014) AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 64(21):e1–76. https://doi.org/10.1016/j.jacc.2014.03.022

Kittleson MM, Panjrath GS, Amancherla K, Davis LL, Deswal A, Dixon DL et al (2023) 2023 ACC Expert Consensus Decision Pathway on Management of Heart Failure with Preserved Ejection Fraction: a Report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol. 81(18):1835–78. https://doi.org/10.1016/j.jacc.2023.03.393

Redfield MMBB (2023) Heart failure with preserved ejection fraction: a review. JAMA 309(10):827–838

Article  Google Scholar 

Roberto M, Lang MFFL, Victor Mor-Avi PFJA, Laura Ernande MPFA, Steven A, Goldstein MTKM, FESC DMMP, PhD LRMF et al (2015) Recommendations for Cardiac Chamber quantification by Echocardiography in adults: an update from the American Society of Echocardiography and the European Association ofCardiovascular Imaging. Eur Heart J– Cardiovasc Imaging 28:1–39. https://doi.org/10.1093/ehjci/jev014

Article  Google Scholar 

Mitchell C, Rahko PS, Blauwet LA, Canaday B, Finstuen JA, Foster MC et al (2019) Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 32(1):1–64. https://doi.org/10.1016/j.echo.2018.06.004

Mehrzad R, Rajab M, Spodick D (2014) The Three Integrated Phases of Left Atrial Macrophysiology and their interactions. Int J Mol Sci 15(9):15146–15160. https://doi.org/10.3390/ijms150915146

Article  PubMed  PubMed Central  Google Scholar 

Jiaqi W, Yongtai L, Peng G, Deyan Y, Kangan C, Taibo C et al (2022) Non-invasive assessment of left atrial structure and function in atrial fibrillation patients. Chin J Cardiovasc Med 27(2):182–186. https://doi.org/10.3969/j.issn.1007-5410.2022.02.018

Article  Google Scholar 

Willems S, Khairy P, Andrade JG, Hoffmann BA, Levesque S, Verma A et al (2016) Redefining the blanking period after catheter ablation for Paroxysmal Atrial Fibrillation. Circulation: Arrhythmia Electrophysiol 9(8). https://doi.org/10.1161/CIRCEP.115.003909

Black-Maier E, Ren X, Steinberg BA, Green CL, Barnett AS, Rosa NS et al (2018) Catheter ablation of atrial fibrillation in patients with heart failure and preserved ejection fraction. Heart Rhythm. 15(5):651– 57. https://doi.org/10.1016/j.hrthm.2017.12.001

Marrouche NFBJAD (2018) Investigators. C. Catheter ablation for Atrial Fibrillation with Heart failure. N Engl J Med 5(378):417–427. https://doi.org/10.1056/NEJMoa1707855

Article  Google Scholar 

Xie Z, Qi B, Wang Z, Li F, Chen C, Li C et al (2023) Ablation for atrial fibrillation improves the outcomes in patients with heart failure with preserved ejection fraction. Europace (London, England). 26(1). https://doi.org/10.1093/europace/euad363

Vecchio N, Ripa L, Orosco A, Tomas L, Mondragón I, Acosta A et al (2019) Atrial Fibrillation in Heart Failure Patients with Preserved or Reduced Ejection Fraction. Prognostic significance of Rhythm control strategy with Catheter Ablation. Journal of Atrial Fibrillation. 11(5):2128. https://doi.org/10.4022/jafib.2128

Ichijo S, Miyazaki S, Kusa S, Nakamura H, Hachiya H, Kajiyama T et al (2018) Impact of catheter ablation of atrial fibrillation on long-term clinical outcomes in patients with heart failure. J Cardiol. 72(3):240– 46. https://doi.org/10.1016/j.jjcc.2018.02.012

Cha Y, Wokhlu A, Asirvatham SJ, Shen W, Friedman PA, Munger TM et al (2011) Success of ablation for Atrial Fibrillation in isolated left ventricular diastolic dysfunction. Circulation: Arrhythmia Electrophysiol 4(5):724–732. https://doi.org/10.1161/CIRCEP.110.960690

Article  Google Scholar 

Giannopoulos G, Kossyvakis C, Vrachatis D, Aggeli C, Tsitsinakis G, Letsas K et al (2019) Effect of cryoballoon and radiofrequency ablation for pulmonary vein isolation on left atrial function in patients with nonvalvular paroxysmal atrial fibrillation: a prospective randomized study (Cryo-LAEF study). J Cardiovasc Electrophysiol 30(7):991–998. https://doi.org/10.1111/jce.13933

Article  Google Scholar 

Antolini M, Brustio A, Morello M, Bongiovanni F, Fornengo C, Gallo C et al (2015) Left atrial function after Radiofrequency catheter ablation of Atrial Fibrillation– Can Pre-ablation function predict contractile improvement during Follow-up?–. Circ J 79(12):2576–2583. https://doi.org/10.1253/circj.CJ-15-0184

Article  PubMed  Google Scholar 

Sramko MMP, Wichterle DMP, Melenovsky VMP, Clemens MM, Fukunaga MM, Peichl PMP et al (2017) Resting and Exercise-Induced Left Atrial Hypertension in Patients with Atrial Fibrillation. JACC. Clinical Electrophysiology. 3(5):461– 69. https://doi.org/10.1016/j.jacep.2016.12.010

Packer M (2019) Effect of catheter ablation on pre-existing abnormalities of left atrial systolic, diastolic, and neurohormonal functions in patients with chronic heart failure and atrial fibrillation. Eur Heart J. 40(23):1873–1879. https://doi.org/10.1093/eurheartj/ehz284

Article  Google Scholar 

Kittleson MM, Panjrath GS, Amancherla K, Davis LL, Deswal A, Dixon DL et al (2023) 2023 ACC Expert Consensus decision pathway on management of Heart failure with preserved ejection fraction. J Am Coll Cardiol 81(18):1835–1878. https://doi.org/10.1016/j.jacc.2023.03.393

Article  PubMed  Google Scholar 

Reddy YNV, Kaye DM, Handoko ML, van de Bovenkamp AA, Tedford RJ, Keck C et al (2022) Diagnosis of Heart Failure with Preserved Ejection Fraction Among Patients with Unexplained Dyspnea. JAMA Cardiol. 7(9):891– 99. https://doi.org/10.1001/jamacardio.2022.1916

Melenovsky VHSRM (2015) Left atrial remodeling and function in Advanced Heart failure with preserved or reduced ejection fraction. Circ Heart Fail 2(8):295–303. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001667

Article  Google Scholar 

Nattel S, Dobrev D (2016) Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat Rev Cardiol. 13(10):575– 90. https://doi.org/10.1038/nrcardio.2016.118

Sohns C, Marrouche NF (2020) Atrial fibrillation and cardiac fibrosis. Eur Heart J. 41(10):1123–1131. https://doi.org/10.1093/eurheartj/ehz786

Article  CAS  Google Scholar 

Sagris M, Vardas EP, Theofilis P, Antonopoulos AS, Oikonomou E, Tousoulis D (2022) Atrial fibrillation: Pathogenesis, predisposing factors, and Genetics. Int J Mol Sci 23(1):6. https://doi.org/10.3390/ijms23010006

Article  CAS  Google Scholar 

Sohns C, Marrouche NF (2019) Reverse remodeling after catheter ablation for Atrial Fibrillation. JACC: Clin Electrophysiol 5(6):689–691. https://doi.org/10.1016/j.jacep.2019.05.004

Article  PubMed  Google Scholar 

Johner N, Namdar M, Shah D (2022) Safety, Efficacy and Prognostic Benefit of Atrial Fibrillation Ablation in Heart failure with preserved ejection fraction. Arrhythm Electrophysiol Rev 11:e18. https://doi.org/10.15420/aer.2022.10

Shah SJKDBB (2016) Phenotype-specific treatment of Heart failure with preserved ejection fraction: a Multiorgan Roadmap. Circulation 134(1):73–90. https://doi.org/10.1161/CIRCULATIONAHA.116.021884

Article  PubMed  PubMed Central  Google Scholar 

Zile MR, Gottdiener JS, Hetzel SJ, McMurray JJ, Komajda M, McKelvie R et al (2011) Prevalence and significance of alterations in Cardiac structure and function in patients with heart failure and a preserved ejection fraction. Circulation 124(23):2491–2501. https://doi.org/10.1161/CIRCULATIONAHA.110.011031

Article  PubMed  Google Scholar 

Melenovsky V, Hwang S, Redfield MM, Zakeri R, Lin G, Borlaug BA (2015) Left atrial remodeling and function in Advanced Heart failure with preserved or reduced ejection fraction. Circulation: Heart Fail 8(2):295–303. https://doi.org/10.1161/CIRCHEARTFAILURE.114.001667

Article  Google Scholar 

Campbell RT, McMurray JJV (2014) Comorbidities and Differential diagnosis in Heart failure with preserved ejection fraction. Heart Fail Clin 10(3):481–501. https://doi.org/10.1016/j.hfc.2014.04.009

Article  PubMed  Google Scholar 

Reddy YNV, Obokata M, Verbrugge FH, Lin G, Borlaug BA (2020) Atrial dysfunction in patients with heart failure with preserved ejection Fraction and Atrial Fibrillation. J Am Coll Cardiol 76(9):1051–1064. https://doi.org/10.1016/j.jacc.2020.07.009

Article  PubMed  PubMed Central  Google Scholar