Labarca G, Gower J, Lamperti L, et al. Chronic intermittent hypoxia in obstructive sleep apnea: a narrative review from pathophysiological pathways to a precision clinical approach. Sleep Breath. 2020;24:751–60.
Liu X, Ma Y, Ouyang R, et al. The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome. J Neuroinflamm. 2020;17:229.
Hunyor I, Cook KM. Models of intermittent hypoxia and obstructive sleep apnea: molecular pathways and their contribution to cancer. Am J Physiol Regul Integr Comp Physiol. 2018;315:669–87.
Beaudin AE, Waltz X, Hanly PJ, Poulin MJ. Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation. Exp Physiol. 2017;102:743–63.
Article CAS PubMed Google Scholar
Marciante AB, Shell B, Farmer GE, Cunningham JT. Role of angiotensin ii in chronic intermittent hypoxia-induced hypertension and cognitive decline. Am J Physiol Regul Integr Comp Physiol. 2021;320:519–25.
Kiernan EA, Smith SM, Mitchell GS, Watters JJ. Mechanisms of microglial activation in models of inflammation and hypoxia: implications for chronic intermittent hypoxia. J Physiol. 2016;594:1563–77.
Article CAS PubMed PubMed Central Google Scholar
Chen PS, Chiu WT, Hsu PL, et al. Pathophysiological implications of hypoxia in human diseases. J Biomed Sci. 2020;27:63.
Article PubMed PubMed Central Google Scholar
Chen LD, Chen Q, Lin XJ, et al. Effect of chronic intermittent hypoxia on gene expression profiles of rat liver: a better understanding of osa-related liver disease. Sleep Breath. 2020;24:761–70.
Zhou WY, Cai ZR, Liu J, et al. Circular RNA: metabolism, functions and interactions with proteins. Mol Cancer. 2020;19:172.
Article CAS PubMed PubMed Central Google Scholar
Kristensen LS, Andersen MS, Stagsted LVW, et al. The biogenesis, biology and characterization of circular rnas. Nat Rev Genet. 2019;20:675–91.
Article CAS PubMed Google Scholar
Chen YC, Hsu PY, Hsiao CC. Epigenetics: a potential mechanism involved in the pathogenesis of various adverse consequences of obstructive sleep apnea. Int J Mol Sci. 2019;20:2937.
Article CAS PubMed PubMed Central Google Scholar
Chen Q, Lin G, Huang J, et al. Expression profile of long non-coding rnas in rat models of osa-induced cardiovascular disease: new insight into pathogenesis. Sleep Breath. 2019;23:795–804.
Liu KX, Chen GP, Lin PL, et al. Detection and analysis of apoptosis- and autophagy-related mirnas of mouse vascular endothelial cells in chronic intermittent hypoxia model. Life Sci. 2018;193:194–9.
Article CAS PubMed Google Scholar
Gao H, Han Z, Huang S, et al. Intermittent hypoxia caused cognitive dysfunction relate to mirnas dysregulation in hippocampus. Behav Brain Res. 2017;335:80–7.
Article CAS PubMed Google Scholar
Hu C, Li J, Du Y, et al. Impact of chronic intermittent hypoxia on the long non-coding rna and mrna expression profiles in myocardial infarction. J Cell Mol Med. 2021;25:421–33.
Article CAS PubMed Google Scholar
Santamaria-Martos F, Benítez I. Circulating microrna profile as a potential biomarker for obstructive sleep apnea diagnosis. Sci Rep. 2019;9:13456.
Article PubMed PubMed Central Google Scholar
Yang X, Niu X, Xiao Y, et al. Mirna expression profiles in healthy osahs and osahs with arterial hypertension: potential diagnostic and early warning markers. Respir Res. 2018;19:194.
Article PubMed PubMed Central Google Scholar
Yousefi H, Maheronnaghsh M, Molaei F, et al. Long noncoding rnas and exosomal lncrnas: classification, and mechanisms in breast cancer metastasis and drug resistance. Oncogene. 2020;39:953–74.
Article CAS PubMed Google Scholar
Kim D, Langmead B, Salzberg SL. Hisat: a fast spliced aligner with low memory requirements. 2015;12:357–60.
Gao Y, Wang J, Zhao F. Ciri: An efficient and unbiased algorithm for de novo circular rna identification. Genome Biol. 2015;16:4.
Article CAS PubMed PubMed Central Google Scholar
Hardwick SA, Chen WY, Wong T, et al. Spliced synthetic genes as internal controls in rna sequencing experiments. Nat Methods. 2016;13:792–8.
Article CAS PubMed Google Scholar
Oksanen J. Vegan: community ecology package. R package version 1.8-5. 2007. http://www.cran.r-project.org.
Wang L, Feng Z, Wang X, et al. Degseq: an r package for identifying differentially expressed genes from rna-seq data. Bioinformatics. 2010;26:136–8.
Alexa A, Rahnenführer J, Lengauer T. Improved scoring of functional groups from gene expression data by decorrelating go graph structure. Bioinformatics. 2006;22:1600–7.
Article CAS PubMed Google Scholar
Shannon P, Markiel A, Ozier O, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13:2498–504.
Article CAS PubMed PubMed Central Google Scholar
Mateika JH, Komnenov D. Intermittent hypoxia initiated plasticity in humans: a multipronged therapeutic approach to treat sleep apnea and overlapping co-morbidities. Exp Neurol. 2017;287:113–29.
Polotsky VY, Rubin AE, Balbir A, et al. Intermittent hypoxia causes rem sleep deficits and decreases eeg delta power in nrem sleep in the c57bl/6j mouse. Sleep Med. 2006;7:7–16.
Peng Y-J, Nanduri J, Khan SA, et al. Hypoxia-inducible factor 2α (hif-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci. 2011;108:3065–70.
Article CAS PubMed PubMed Central Google Scholar
Li C, Zhang Y, Chen Y, et al. Cell-autonomous autophagy protects against chronic intermittent hypoxia induced sensory nerves and endothelial dysfunction of the soft palate. Med Sci Monit. 2020;26: 920878.
Zheng D, Cao T, Zhang LL, et al. Targeted inhibition of calpain in mitochondria alleviates oxidative stress-induced myocardial injury. Acta Pharmacol Sin. 2021;42:909–20.
Article CAS PubMed Google Scholar
Knyazev EN, Petrov VA, Gazizov IN, et al. Oxyquinoline-dependent changes in claudin-encoding genes contribute to impairment of the barrier function of the trophoblast monolayer. Bull Exp Biol Med. 2019;166:369–72.
Article CAS PubMed Google Scholar
Luk’yanova LD, Kirova YI, Germanova EL. Peculiarities of immediate response of respiratory chain enzymes in rat cerebral cortex to hypoxia. Bull Exp Biol Med. 2019;166:426–31.
Article CAS PubMed Google Scholar
Lukyanova L, Germanova E, Khmil N, et al. Signaling role of mitochondrial enzymes and ultrastructure in the formation of molecular mechanisms of adaptation to hypoxia. Int J Mol Sci. 2021;22:
Yang X, Ren W, Shao Y, Chen Y. Mir-466b-1-3p regulates p-glycoprotein expression in rat cerebral microvascular endothelial cells. Neurosci Lett. 2017;645:60–6.
Article CAS PubMed Google Scholar
Su X, Xiao D, Huang L, et al. Microrna alteration in developing rat oligodendrocyte precursor cells induced by hypoxia-ischemia. J Neuropathol Exp Neurol. 2019;78:900–9.
Comments (0)