Do the Early Pregnancy Serum Levels of VEGF & PlGF Predict the Onset of Preeclampsia: An Experience from a Tertiary Center

Hypertension in pregnancy. Report of the American college of obstetricians and gynecologists’ task force on hypertension in pregnancy. Obstet Gynecol. 2013;122(5):1122–31.

Kurtoglu E, Altunkaynak BZ, Aydin I, Ozdemir AZ, Altun G, Kokcu A, Kaplan S. Role of vascular endothelial growth factor and placental growth factor expression on placenta structure in pre-eclamptic pregnancy. J Obstet Gynaecol Res. 2015;41(10):1533–40.

Article  PubMed  CAS  Google Scholar 

Llurba E, Crispi F, Verlohren S. Update on the pathophysiological implications and clinical role of angiogenic factors in pregnancy. Fetal Diagn Ther. 2015;37(2):81–92.

Article  PubMed  Google Scholar 

Andersen LB, Dechend R, Jørgensen JS, Luef BM, Nielsen J, Barington T, Christesen HT. Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective Odense child cohort. Hypertens Pregnancy. 2016;35(3):405–19.

Article  PubMed  CAS  Google Scholar 

Roberts JM, Lain KY. Recent insights into the pathogenesis of pre-eclampsia. Placenta. 2002;23(5):359–72.

Article  PubMed  CAS  Google Scholar 

Kaufmann P, Mayhew TM, Charnock-Jones DS. Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy. Placenta. 2004;25:114–26.

Article  PubMed  CAS  Google Scholar 

Zhou Y, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ. Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. Am J Pathol. 2002;160(4):1405–23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Eddy AC, Bidwell GL 3rd, George EM. Pro-angiogenic therapeutics for preeclampsia. Biol Sex Differ. 2018;9(1):36.

Article  PubMed  PubMed Central  Google Scholar 

Varughese B, Bhatla N, Kumar R, Dwivedi SN, Dhingra R. Circulating angiogenic factors in pregnancies complicated by pre-eclampsia. Natl Med J India 2010;23(2):77–81.

Palmer KR, Tong S, Kaitu’u-Lino TJ. Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis. Mol Hum Reprod. 2017;23(2):69–78.

PubMed  CAS  Google Scholar 

Thadhani R, Mutter WP, Wolf M, Levine RJ, Taylor RN, Sukhatme VP, et al. First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia. J Clin Endocrinol Metab. 2004;89(2):770–5.

Article  PubMed  CAS  Google Scholar 

Torry DS, Wang HS, Wang TH, Caudle MR, Torry RJ. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol. 1998;179:1539–44.

Article  PubMed  CAS  Google Scholar 

Tjoa ML, van Vugt JM, Mulders MA, Schutgens RB, Oudejans CB, van Wijk IJ. Plasma placenta growth factor levels in mid-trimester pregnancies. Obstet Gynecol. 2001;98(4):600–7.

PubMed  CAS  Google Scholar 

Romero R, Nien JK, Espinoza J, Todem D, Fu W, Chung H, et al. A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate. J Matern Fetal Neonatal Med. 2008;21(1):9–23.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350(7):672–83.

Article  PubMed  CAS  Google Scholar 

Kurtoglu E, Avci B, Kokcu A, Celik H, Cengiz Dura M, Malatyalioglu E, Zehra Ozdemir A. Serum VEGF and PGF May be significant markers in prediction of severity of preeclampsia. J Matern Fetal Neonatal Med. 2016;29(12):1987–92.

Article  PubMed  CAS  Google Scholar 

Lyall F, Young A, Boswell F, et al. Placental expression of vascular endothelial growth factor in placentae from pregnancies complicated by pre-eclampsia and intrauterine growth restriction does not support placental hypoxia at delivery. Placenta. 1997;18:269–76.

Article  PubMed  CAS  Google Scholar 

Sun SG, Shen N, Zheng YH, Shang T. [Expression of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and sFlt-1 in preeclampsia placenta]. Hypertension. 2006;41(7):440–4.

Google Scholar 

Wang F, Bai H, Fan P, Liu XH, He GL, Liu R. Vasohibin and VEGF protein levels in placentae from pregnancies complicated by severe pre-eclampsia]. Sichuan da xue xue bao. Yi xue ban J Sichuan Univ Med Sci Ed. 2010;41(5):814–7.

PubMed  CAS  Google Scholar 

Simmons LA, Hennessy A, Gillin AG, Jeremy RW. Uteroplacental blood flow and placental vascular endothelial growth factor in normotensive and pre-eclamptic pregnancy. BJOG. 2000;107(5):678–85.

Article  PubMed  CAS  Google Scholar 

Comments (0)

No login
gif