L-lactate provision in preterm newborns: friend or foe?

Omar Ibrahim, I. et al. Positive impact of Sodium L-Lactate supplementation on blood acid-base status in preterm newborns. Pediatr Res. https://doi.org/10.1038/s41390-025-03963-9 (2025).

Brooks, G. A. Cell-cell and intracellular lactate shuttles. J. Physiol. 587, 5591–5600 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Laughlin, M. R., Taylor, J., Chesnick, A. S., DeGroot, M. & Balaban, R. S. Pyruvate and lactate metabolism in the in vivo dog heart. Am. J. Physiol. 264, H2068–H2079 (1993).

CAS  PubMed  Google Scholar 

Pellerin, L. & Magistretti, P. J. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc. Natl. Acad. Sci. USA 91, 10625–10629 (1994).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dienel, G. A. Lactate shuttling and lactate use as fuel after traumatic brain injury: metabolic considerations. J. Cereb. Blood Flow. Metab. 34, 1736–1748 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vannucci, R. C., Yager, J. Y. & Vannucci, S. J. Cerebral glucose and energy utilization during the evolution of hypoxic-ischemic brain damage in the immature rat. J. Cereb. Blood Flow. Metab. 14, 279–288 (1994).

Article  CAS  PubMed  Google Scholar 

Izumi, Y., Benz, A. M., Zorumski, C. F. & Olney, J. W. Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices. Neuroreport 5, 617–620 (1994).

Article  CAS  PubMed  Google Scholar 

Powell, C. L., Hernandez, M. J. & Vannucci, R. C. The effect of Lactacidemia on regional cerebral blood flow in the newborn dog. Brain Res 349, 314–316 (1985).

Article  CAS  PubMed  Google Scholar 

Roithmaier, A. et al. Randomized controlled trial of ringer solution versus serum for partial exchange transfusion in neonatal Polycythaemia. Eur. J. Pediatr. 154, 53–56 (1995).

Article  CAS  PubMed  Google Scholar 

Datta, P. K. et al. Dextrose-containing intraoperative fluid in neonates: a randomized controlled trial. Paediatr. Anaesth. 26, 599–607 (2016).

Article  PubMed  Google Scholar 

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