Neuromuscular Manifestations of Leprosy and Update on Treatment

Montes N, Jáuregui C, Dinarès R, Triay V, Fernández-Vilela A, Ruiz J, et al. Tracing Leprosy: The paleopathological study of the individuals excavated from the Sant Llàtzer leprosarium in Barcelona, Spain (12th-18th c.). Int J Paleopathol. 2025;48:23–33.

Article  PubMed  Google Scholar 

Rashidi M, Pitton Rissardo J, Byroju VV, Fornari Caprara AL, Rashidi F, Prathiraja O, et al. Exploring the Neurological Manifestations of Leprosy: Clinical Insights and Implications. Cureus. 2025 [cited 2025 Feb 16]; Available from: https://www.cureus.com/articles/335410-exploring-the-neurological-manifestations-of-leprosy-clinical-insights-and-implications

Ridley DS, Jopling WH. Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis. 1966;34:255–73.

CAS  PubMed  Google Scholar 

Soares GMMM, de Souza EA, Ferreira AF, García GSM, de Oliveira MLWDR, de Pinheiro ABM, et al. Socio-demographic and clinical factors of leprosy cases associated with the performance of the evaluation of their contacts in Ceará, Brazil 2008–2019. Epidemiol Serv Saúde. 2021;30:e2020585.

Article  PubMed  Google Scholar 

Soni D, Sharma B, Karkhur S. Anterior chamber angle granuloma: A rare ocular manifestation of histoid lepromatous leprosy. Indian J Ophthalmol. 2020;68:2031.

Article  PubMed  PubMed Central  Google Scholar 

Cuevas J, Rodríguez-Peralto JL, Carrillo R, Contreras F. Erythema nodosum leprosum: reactional leprosy. Semin Cutan Med Surg. 2007;26:126–30.

Article  CAS  PubMed  Google Scholar 

Chavez-Alvarez S, Herz-Ruelas M, Ocampo-Candiani J, Gomez-Flores M. Type 2 leprosy reaction resembling Sweet syndrome: Review of new and published cases. Australas J Dermatol. 2020;61:e234–7.

Article  PubMed  Google Scholar 

Spitz CN, Pitta IJR, Andrade L, De Carvalho LB, De Carvalho DMT, Schmidt FDR, et al. Case report: Myelitis and ganglionitis, an atypical presentation of Hansen’s disease. Front Med. 2024;11:1400423.

Article  Google Scholar 

Sengar P, Verma R, Singh VK, Paliwal VK. Pearls & Oy-sters: “Quiet Nerve Paralysis” due to Symmetrical Neuropathy in Pure Neuritic Leprosy. Neurology [Internet]. 2021 [cited 2025 Feb 17];96. Available from: https://www.neurology.org/doi/https://doi.org/10.1212/WNL.0000000000011880

Bhoi SK, Naik S, Purkait S. Pure Neuritic Leprosy with Bilateral Foot Drop and Central Nervous Involvement: A Clinical, Electrophysiological, and MR Correlation. Neurol India. 2021;69:1349.

Article  PubMed  Google Scholar 

Cabral N, de Figueiredo V, Gandini M, de Souza CF, Medeiros RA, Lery LMS, et al. Modulation of the Response to Mycobacterium leprae and Pathogenesis of Leprosy. Front Microbiol [Internet]. 2022 [cited 2025 Feb 17];13. Available from: https://www.frontiersin.org/journals/microbiology/articles/https://doi.org/10.3389/fmicb.2022.918009/full

Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T. Reservoirs and transmission routes of leprosy; A systematic review. PLoS Negl Trop Dis. 2020;14:e0008276.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stefani MM, Guerra JG, Sousa ALM, Costa MB, Oliveira MLW, Martelli CT, et al. Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report. BMC Infect Dis. 2009;9:75.

Article  PubMed  PubMed Central  Google Scholar 

Serrano-Coll H, Wan EL, Restrepo-Rivera L, Cardona-Castro N. Leprosy reactions: Unraveling immunological mechanisms underlying tissue damage in leprosy patients. Pathog Dis. 2024;82:ftae013.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alizadeh A, Dyck SM, Karimi-Abdolrezaee S. Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci [Internet]. 2015 [cited 2025 Mar 3];8. Available from: http://journal.frontiersin.org/Article/https://doi.org/10.3389/fnmol.2015.00035/abstract

Scollard DM. The biology of nerve injury in leprosy. Leprosy. 2008;79:242–53.

Article  Google Scholar 

Froes LAR, Sotto MN, Trindade MAB. Leprosy: clinical and immunopathological characteristics. An Bras Dermatol. 2022;97:338–47.

Article  PubMed  Google Scholar 

Hafsi W, Badri T. Erythema Nodosu. 2023 [cited 2025 Mar 3]; Available from: https://www.ncbi.nlm.nih.gov/books/NBK470369

Vashisht D, Neema S, Tripathy DM, Sengupta P. Bullous erythema nodosum leprosum through the dermoscope. Dermatol Pract Concept. 2022;12:e2022027.

Article  PubMed  PubMed Central  Google Scholar 

Kumar B, Kar HK, Dogra S. IAL Textbook of Leprosy. Jaypee Brothers Medical Publishers; 2023.

Sadhu S, Mitra DK. Emerging Concepts of Adaptive Immunity in Leprosy. Front Immunol. 2018;9:604.

Article  PubMed  PubMed Central  Google Scholar 

Razdan N, Barghavi V, Sadhu S. Pure neuritic leprosy: Latest advancements and diagnostic modalities. Diagn Microbiol Infect Dis. 2024;110:116529.

Article  CAS  PubMed  Google Scholar 

Gupta S, Mehta A, Lakhtakia R, Nema S. An Unusual Presentation of Lepromatous Leprosy. Med J Armed Forces India. 2006;62:392–3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Narayanappa G, Nandeesh BN. Infective myositis. Brain Pathol. 2021;31:e12950.

Article  PubMed  PubMed Central  Google Scholar 

Neder L, Rondon DA, Cury SS, Da Silva CA. Musculoskeletal manifestations and autoantibodies in children and adolescents with leprosy. J Pediatr. 2014;90:457–63.

Article  Google Scholar 

Chopra A. Rheumatic and other musculoskeletal manifestations and autoantibodies in childhood and adolescent leprosy: significance and relevance. J Pediatr. 2014;90:431–6.

Article  Google Scholar 

Spierings E, De Boer T, Zulianello L, Ottenhoff TH. Novel mechanisms in the immunopathogenesis of leprosy nerve damage: The role of Schwann cells, T cells and Mycobacterium leprae. Immunol Cell Biol. 2000;78:349–55.

Article  CAS  PubMed  Google Scholar 

Jardim MR, Chimelli L, Faria SC, Fernandes PV, Néri JADC, Sales AM, et al. Clinical, electroneuromyographic and morphological studies of pure neural leprosy in a Brazilian referral centre. Lepr Rev. 2004;75:242–53.

PubMed  Google Scholar 

Uplekar MW, Antia NH. Clinical and histopathological observations on pure neuritic leprosy. Indian J Lepr. 1986;58:513–21.

CAS  PubMed  Google Scholar 

Talwar S, Jha PK, Tiwari VD. Neuritic leprosy: epidemiology and therapeutic responsiveness. Lepr Rev. 1992;63:263–8.

CAS  PubMed  Google Scholar 

Mahajan PM, Jogaikar DG, Mehta JM. A study of pure neuritic leprosy: clinical experience. Indian J Lepr. 1996;68:137–41.

CAS  PubMed  Google Scholar 

Girdhar BK. Neuritic leprosy. Indian J Lepr. 1996;68:35–42.

CAS  PubMed  Google Scholar 

Kumar S, Alexander M, Gnanamuthu C. Cranial nerve involvement in patients with leprous neuropathy. Neurol India. 2006;54:283.

Article  PubMed  Google Scholar 

de Freitas MRG, Nascimento OJM, Quaglino EAM, Oliveira A, Hahn MD. Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases. Arq Neuro-Psiquiatr. 2003;61:542–6.

Article  Google Scholar 

de Freitas MRG, Said G. Chapter 28 - Leprous neuropathy. In: Said G, Krarup C, editors. Handbook of Clinical Neurology [Internet]. Elsevier; 2013 [cited 2025 Mar 21]. p. 499–514. Available from: https://www.sciencedirect.com/science/article/pii/B978044452902200028X

Raicher I, Stump PR, Baccarelli R, Marciano LH, Ura S, Virmond MC, et al. Neuropathic pain in leprosy. Clin Dermatol. 2016;34:59–65.

Article  PubMed  Google Scholar 

Khadilkar SV, Patil SB, Shetty VP. Neuropathies of leprosy. J Neurol Sci. 2021;420:117288.

Article  CAS  PubMed  Google Scholar 

Huang C-Y, Su S-B, Chen K-T. An update of the diagnosis, treatment, and prevention of leprosy: A narrative review. Medicine. 2024;103:e39006.

Article  PubMed  PubMed Central  Google Scholar 

Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL. The continuing challenges of leprosy. Clin Microbiol Rev. 2006;19:338–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

D C. Therapy of Leprosy- Present Strategies and Recent Trends with Immunotherapy. [cited 2025 Mar 2]; Available from: https://clinmedjournals.org/articles/ijdrt/journal-of-dermatology-research-and-therapy-ijdrt-6-093.php

Ebenezer GJ, Scollard DM. Treatment and evaluation advances in leprosy neuropathy. Neurotherapeutics. 2021;18:2337–50.

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