Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Heart J. 2022;43(38):3618–731.

CAS  PubMed  Google Scholar 

Maron BA, Brittain EL, Hess E, Waldo SW, Barón AE, Huang S, et al. Pulmonary vascular resistance and clinical outcomes in patients with pulmonary hypertension: a retrospective cohort study. Lancet Respir Med. 2020;8(9):873–84.

PubMed  PubMed Central  Google Scholar 

Hirashiki A, Kondo T, Adachi S, Nakano Y, Shimazu S, Shimizu S, et al. Prognostic value of pulmonary hypertension in ambulatory patients with non-ischemic dilated cardiomyopathy. Circ J. 2014;78(5):1245–53.

CAS  PubMed  Google Scholar 

Miller WL, Grill DE, Borlaug BA. Clinical features, hemodynamics, and outcomes of pulmonary hypertension due to chronic heart failure with reduced ejection fraction: pulmonary hypertension and heart failure. JACC Heart Fail. 2013;1(4):290–9.

PubMed  Google Scholar 

Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA. Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. 2018;3(4):298–306.

PubMed  PubMed Central  Google Scholar 

Klinger JR, Wu B, Morland K, Classi P, Fiano R, Grabich S. Burden of pulmonary hypertension due to chronic obstructive pulmonary disease: Analysis of exacerbations and healthcare resource utilization in the United States. Respir Med. 2023;1(219): 107412.

Google Scholar 

Cook DP, Xu M, Martucci VL, Annis JS, Aldrich MC, Hemnes AR, et al. Clinical insights into pulmonary hypertension in chronic obstructive pulmonary disease. Pulm Circ. 2022;12(1): e12006.

CAS  PubMed  PubMed Central  Google Scholar 

Hoeper MM, Humbert M, Souza R, Idrees M, Kawut SM, Sliwa-Hahnle K, et al. A global view of pulmonary hypertension. Lancet Respir Med. 2016;4(4):306–22.

PubMed  Google Scholar 

Leber L, Beaudet A, Muller A. Epidemiology of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: identification of the most accurate estimates from a systematic literature review. Pulm Circ. 2021;11(1):2045894020977300.

PubMed  PubMed Central  Google Scholar 

Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, et al. Pulmonary arterial hypertension in France: results from a national registry. Am J Respir Crit Care Med. 2006;173(9):1023–30.

PubMed  Google Scholar 

Peacock AJ, Murphy NF, McMurray JJV, Caballero L, Stewart S. An epidemiological study of pulmonary arterial hypertension. Eur Respir J. 2007;30(1):104–9.

CAS  PubMed  Google Scholar 

Badesch DB, Raskob GE, Elliott CG, Krichman AM, Farber HW, Frost AE, et al. Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest. 2010;137(2):376–87.

PubMed  Google Scholar 

Rich S, Dantzker DR, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med. 1987;107(2):216–23.

CAS  PubMed  Google Scholar 

Chang KY, Duval S, Badesch DB, Bull TM, Chakinala MM, De Marco T, et al. Mortality in Pulmonary Arterial Hypertension in the Modern Era: Early Insights From the Pulmonary Hypertension Association Registry. J Am Heart Assoc. 2022;11(9): e024969.

PubMed  PubMed Central  Google Scholar 

Tonelli AR, Arelli V, Minai OA, Newman J, Bair N, Heresi GA, et al. Causes and Circumstances of Death in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2013;188(3):365–9.

PubMed  PubMed Central  Google Scholar 

Kaymaz C, Akbulut M, Basarici I, Yildirimturk O, Asker M, Kaya EB, et al. Improving morbidity and mortality in patients with pulmonary hypertension: insights from a nation-wide registry. Eur Heart J. 2024;45(Supplement_1):ehae666.2230.

Google Scholar 

Benza RL, Miller DP, Barst RJ, Badesch DB, Frost AE, McGoon MD. An evaluation of long-term survival from time of diagnosis in pulmonary arterial hypertension from the REVEAL Registry. Chest. 2012;142(2):448–56.

PubMed  Google Scholar 

Hoeper MM, Pausch C, Grünig E, Staehler G, Huscher D, Pittrow D, et al. Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry. Eur Respir J. 2022;59(6):2102024.

CAS  PubMed  PubMed Central  Google Scholar 

Bédard E, Dimopoulos K, Gatzoulis MA. Has there been any progress made on pregnancy outcomes among women with pulmonary arterial hypertension? Eur Heart J. 2009;30(3):256–65.

PubMed  Google Scholar 

Pieper PG, Lameijer H, Hoendermis ES. Pregnancy and pulmonary hypertension. Best Pract Res Clin Obstet Gynaecol. 2014;28(4):579–91.

PubMed  Google Scholar 

Sliwa K, van Hagen IM, Budts W, Swan L, Sinagra G, Caruana M, et al. Pulmonary hypertension and pregnancy outcomes: data from the Registry Of Pregnancy and Cardiac Disease (ROPAC) of the European Society of Cardiology. Eur J Heart Fail. 2016;18(9):1119–28.

PubMed  Google Scholar 

Weiss BM, Zemp L, Seifert B, Hess OM. Outcome of pulmonary vascular disease in pregnancy: a systematic overview from 1978 through 1996. J Am Coll Cardiol. 1998;31(7):1650–7.

CAS  PubMed  Google Scholar 

Thomas E, Yang J, Xu J, Lima FV, Stergiopoulos K. Pulmonary Hypertension and Pregnancy Outcomes: Insights From the National Inpatient Sample. J Am Heart Assoc. 2017;6(10): e006144.

PubMed  PubMed Central  Google Scholar 

Galiè N, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Respir J. 2015;46(4):903–75.

PubMed  Google Scholar 

Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy: The Task Force for the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J. 2018;39(34):3165–241.

PubMed  Google Scholar 

Hemnes AR, Kiely DG, Cockrill BA, Safdar Z, Wilson VJ, Al Hazmi M, et al. Statement on pregnancy in pulmonary hypertension from the Pulmonary Vascular Research Institute. Pulm Circ. 2015;5(3):435–65.

CAS  PubMed  PubMed Central  Google Scholar 

Ma R, Gao H, Cui J, Shi H, Yang Z, Jin Z, et al. Pregnancy feasibility in women with mild pulmonary arterial hypertension: a systematic review and meta-analysis. BMC Pregnancy Childbirth. 2023;23(1):427.

PubMed  PubMed Central  Google Scholar 

Kovacs G, Berghold A, Scheidl S, Olschewski H. Pulmonary arterial pressure during rest and exercise in healthy subjects: a systematic review. Eur Respir J. 2009;34(4):888–94.

CAS  PubMed  Google Scholar 

Wylie BJ, Epps KC, Gaddipati S, Waksmonski CA. Correlation of transthoracic echocardiography and right heart catheterization in pregnancy. J Perinat Med. 2007;35(6):497–502.

PubMed  Google Scholar 

Hytten FE, Paintin DB. Increase in Plasma Volume During Normal Pregnancy. BJOG: An Int J Obstet Gynaecol. 1963;70(3):402–7.

CAS  Google Scholar 

Rovinsky JJ, Jaffin H. Cardiovascular hemodynamics in pregnancy. I blood and plasma volumes in multiple pregnancy. Am J Obstet Gynecol. 1965;93:1–15.

CAS  PubMed  Google Scholar 

Bernstein IM, Ziegler W, Badger GJ. Plasma volume expansion in early pregnancy. Obstet Gynecol. 2001;97(5 Pt 1):669–72.

CAS  PubMed  Google Scholar 

Aguree S, Gernand AD. Plasma volume expansion across healthy pregnancy: a systematic review and meta-analysis of longitudinal studies. BMC Pregnancy Childbirth. 2019;19(19):508.

PubMed  PubMed Central  Google Scholar 

Sanghavi M, Rutherford JD. Cardiovascular Physiology of Pregnancy. Circulation. 2014;130(12):1003–8.

PubMed  Google Scholar 

Lumbers ER, Pringle KG. Roles of the circulating renin-angiotensin-aldosterone system in human pregnancy. Am J Physiol Regul Integr Comp Physiol. 2014;306(2):R91-101.

CAS  PubMed  Google Scholar 

Longo LD. Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control. Am J Physiol. 1983;245(5 Pt 1):R720-729.

CAS  PubMed  Google Scholar 

Duvekot JJ, Cheriex EC, Pieters FA, Menheere PP, Peeters LH. Early pregnancy changes in hemodynamics and volume homeostasis are consecutive adjustments triggered by a primary fall in systemic vascular tone. Am J Obstet Gynecol. 1993;169(6):1382–92.

CAS  PubMed  Google Scholar 

Clark SL, Cotton DB, Lee W, Bishop C, Hill T, Southwick J, et al. Central hemodynamic assessment of normal term pregnancy. Am J Obstet Gynecol. 1989;161(6 Pt 1):1439–42.

CAS  PubMed  Google Scholar 

Mulder E, de Haas S, Mohseni Z, Schartmann N, Abo Hasson F, Alsadah F, et al. Cardiac output and peripheral vascular resistance during normotensive and hypertensive pregnancy – a systematic review and meta-analysis. BJOG. 2022;129(5):696–707.

CAS  PubMed