Alhammer AH, Alkufi SG, Al-Juboori SI, Mudhafar SA (2024) KIF15 inhibitor suppresses the proliferation and migration, and induces the apoptosis of breast cancer cells. World Academy of Sciences Journal 7(1):3

Google Scholar 

Antoniotti S, Ruffinatti FA, Torriano S, Luganini A, D’Alessandro R, Lovisolo D (2016) REST levels affect the functional expression of voltage dependent calcium channels and the migratory activity in immortalized GnRH neurons. Neurosci Lett 629:19–25

CAS  PubMed  Google Scholar 

Ari C, Borysov SI, Wu J, Padmanabhan J, Potter H (2014) Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiol Aging 35(8):1839–1849

CAS  PubMed  PubMed Central  Google Scholar 

Barbosa R, Acevedo LA, Marmorstein R (2021) The MEK/ERK network as a therapeutic target in human cancer. Mol Cancer Res 19(3):361–374

CAS  PubMed  Google Scholar 

Ben-David U, Amon A (2020) Context is everything: aneuploidy in cancer. Nat Rev Genet 21(1):44–62

CAS  PubMed  Google Scholar 

Bernard P-L, Delconte R, Pastor S, Laletin V, Da Silva CC, Goubard A, Josselin E, Castellano R, Krug A, Vernerey J (2022) Targeting CISH enhances natural cytotoxicity receptor signaling and reduces NK cell exhaustion to improve solid tumor immunity. J Immunother Cancer 10(5):e004244

PubMed  PubMed Central  Google Scholar 

Bi H, Hou X, Shen Q, Liu Z, Zhu X, Ma L, Lu J (2023) Knockdown of KIF15 suppresses proliferation of prostate cancer cells and induces apoptosis through PI3K/Akt signaling pathway. Cell Death Discov 9(1):326

CAS  PubMed  PubMed Central  Google Scholar 

Boudin L, De Nonneville A, Finetti P, Guittard G, Nunes JA, Birnbaum D, Mamessier E, Bertucci F (2022) CISH expression is associated with metastasis-free interval in triple-negative breast cancer and refines the prognostic value of PDL1 expression. Cancers (Basel) 14(14):3356

CAS  PubMed  Google Scholar 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68(6):394–424

PubMed  Google Scholar 

Buster DW, Baird DH, Yu W, Solowska JM, Chauvière M, Mazurek A, Kress M, Baas PW (2003) Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development. J Neurocytol 32:79–96

CAS  PubMed  Google Scholar 

Cai Y, Lai Q, Zhang X, Zhang Y, Zhang M, Gu S, Qin Y, Hou J, Zhao L (2023) Kinesin superfamily member 15 knockdown inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. Korean J Physiol Pharmacol 27(5):457–470

CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Huang R, Xia T, Wang C, Xiao X, Lu S, Chen X, Ouyang Y, Deng X, Miao J (2023) The m6A reader IGF2BP3 preserves NOTCH3 mRNA stability to sustain Notch3 signaling and promote tumor metastasis in nasopharyngeal carcinoma. Oncogene 42(48):3564–3574

CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Fu D, Zhao H, Cheng W, Xu F (2020) GSG2 (Haspin) promotes development and progression of bladder cancer through targeting KIF15 (kinase-12). Aging (Albany NY) 12(10):8858

CAS  PubMed  Google Scholar 

Ding L, Li B, Yu X, Li Z, Li X, Dang S, Lv Q, Wei J, Sun H, Chen H (2020) KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis. Cancer Cell Int 20:1–14

Google Scholar 

Ding Z, Xu F, Li G, Tang J, Tang Z, Jiang P, Wu H (2015) Knockdown of Akt2 expression by shRNA inhibits proliferation, enhances apoptosis, and increases chemosensitivity to paclitaxel in human colorectal cancer cells. Cell Biochem Biophys 71:383–388

CAS  PubMed  Google Scholar 

Dong M, Li C, Jiapaer P, Li X, Xue X, Jiang K, Sheng J (2021) KIF15 expression characteristics: relevance toneo-adjuvant chemotherapy efficacy in breast cancer. Oncology and Translational Medicine 7(2):69–75

CAS  Google Scholar 

Dong Z, Wu S, Zhu C, Wang X, Li Y, Chen X, Liu D, Qiang L, Baas PW, Liu M (2019) Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish. Traffic 20(1):71–81

CAS  PubMed  Google Scholar 

Feng J, Hu Z, Chen H, Hua J, Wu R, Dong Z, Qiang L, Liu Y, Baas PW, Liu M (2016) Depletion of kinesin-12, a myosin-IIB-interacting protein, promotes migration of cortical astrocytes. J Cell Sci 129(12):2438–2447

CAS  PubMed  PubMed Central  Google Scholar 

Ferenz NP, Gable A, Wadsworth P (2010) Mitotic functions of kinesin-5. Seminars in cell & developmental biology. Elsevier

Gao L, Zhang W, Zhang J, Liu J, Sun F, Liu H, Hu J, Wang X, Wang X, Su P (2021) KIF15-mediated stabilization of AR and AR-V7 contributes to enzalutamide resistance in prostate cancer. Can Res 81(4):1026–1039

CAS  Google Scholar 

Gao L, Zhao R, Liu J, Zhang W, Sun F, Yin Q, Wang X, Wang M, Feng T, Qin Y (2021) KIF15 promotes progression of castration resistant prostate cancer by activating EGFR signaling pathway. Front Oncol 11:679173

CAS  PubMed  PubMed Central  Google Scholar 

Gao X, Zhu L, Lu X, Wang Y, Li R, Jiang G (2020) KIF15 contributes to cell proliferation and migration in breast cancer. Hum Cell 33:1218–1228

CAS  PubMed  Google Scholar 

Ge W, Chen Y, Guo Y, Zhao D, Mu L, Zhang K, Zhuo W (2021) KIF15 upregulation promotes leiomyosarcoma cell growth via promoting USP15-mediated DEK deubiquitylation. Biochem Biophys Res Commun 570:117–124

CAS  PubMed  Google Scholar 

Guo J-Z, Wu Q-J, Liu F-H, Gao C, Gong T-T, Li G (2022) Review of Mendelian randomization studies on endometrial cancer. Front Endocrinol 13:783150

Google Scholar 

Guo Q, Qiu P, Pan K, Liang H, Liu Z, Lin J (2024) Integrated machine learning algorithms identify KIF15 as a potential prognostic biomarker and correlated with stemness in triple-negative breast cancer. Sci Rep 14(1):21449

CAS  PubMed  PubMed Central  Google Scholar 

Gupta SK, Gressens P, Mani S (2009) NRSF downregulation induces neuronal differentiation in mouse embryonic stem cells. Differentiation 77(1):19–28

CAS  PubMed  Google Scholar 

Han C, Yang B, Deng Y, Hu P, Hu B, Liu X, Wang T, Li C, Liu J, Yuan H (2025) Atractylenolide I ameliorated the growth and enzalutamide resistance of castration-resistant prostate cancer by targeting KIF15. Chin Med 20(1):35

CAS  PubMed  PubMed Central  Google Scholar 

He C-F, Xue W-J, Xu X-D, Wang J-T, Wang X-R, Feng Y, Zhou H-G, Guo J-C (2022) Knockdown of NRSF alleviates ischemic brain injury and microvasculature defects in diabetic MCAO mice. Front Neurol 13:869220

PubMed  PubMed Central  Google Scholar 

He J-J, Li Z, Rong Z-X, Gao J, Mu Y, Guan Y-D, Ren X-X, Zi Y-Y, Liu L-Y, Fan Q (2020) M6A reader YTHDC2 promotes radiotherapy resistance of nasopharyngeal carcinoma via activating IGF1R/AKT/S6 signaling axis. Front Oncol 10:1166

PubMed  PubMed Central  Google Scholar 

Hess K, Oliverio R, Nguyen P, Le D, Ellis J, Kdeiss B, Ord S, Chalkia D, Nikolaidis N (2018) Concurrent action of purifying selection and gene conversion results in extreme conservation of the major stress-inducible Hsp70 genes in mammals. Sci Rep 8(1):5082

PubMed  PubMed Central  Google Scholar 

Hirokawa N, Noda Y (2008) Intracellular transport and kinesin superfamily proteins, KIFs: structure, function, and dynamics. Physiol Rev 88(3):1089–1118

CAS  PubMed  Google Scholar 

Hirokawa N, Tanaka Y (2015) Kinesin superfamily proteins (KIFs): various functions and their relevance for important phenomena in life and diseases. Exp Cell Res 334(1):16–25

CAS  PubMed  Google Scholar 

Huang J, Sun X, Diao G, Li R, Guo J, Han J (2023) KIF15 knockdown inhibits the development of endometrial cancer by suppressing epithelial-mesenchymal transition and stemness through Wnt/β-catenin signaling. Environ Toxicol 38(8):1824–1834

CAS  PubMed  Google Scholar 

Hugen N, Brown G, Glynne-Jones R, de Wilt JH, Nagtegaal ID (2016) Advances in the care of patients with mucinous colorectal cancer. Nat Rev Clin Oncol 13(6):361–369

CAS  PubMed  Google Scholar 

Kapitein LC, Peterman EJ, Kwok BH, Kim JH, Kapoor TM, Schmidt CF (2005) The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks. Nature 435(7038):114–118

CAS  PubMed  Google Scholar 

Kawamura M, Sato S, Matsumoto G, Fukuda T, Shiba-Fukushima K, Noda S, Takanashi M, Mori N, Hattori N (2019) Loss of nuclear REST/NRSF in aged-dopaminergic neurons in Parkinson’s disease patients. Neurosci Lett 699:59–63

CAS  PubMed  Google Scholar 

Kestav K, Uri A, Lavogina D (2017) Structure, roles and inhibitors of a mitotic protein kinase haspin. Curr Med Chem 24(21):2276–2293

CAS  PubMed